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ADAM10/17 [plasma membrane]
Stable Identifier
R-HSA-1852617
Type
Set [CandidateSet]
Species
Homo sapiens
Compartment
plasma membrane
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
Signaling by NOTCH1 in Cancer (Homo sapiens)
Signaling by NOTCH1 HD Domain Mutants in Cancer (Homo sapiens)
Constitutive Signaling by NOTCH1 HD Domain Mutants (Homo sapiens)
NOTCH1 HD domain mutants are cleaved to produce NEXT1 irrespective of ligand binding (Homo sapiens)
ADAM10/17:Zn2+ [plasma membrane] (Homo sapiens)
ADAM10/17 [plasma membrane] (Homo sapiens)
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer (Homo sapiens)
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants (Homo sapiens)
NOTCH1 HD+PEST domain mutants are cleaved by ADAM10/17 irrespective of ligand binding (Homo sapiens)
ADAM10/17:Zn2+ [plasma membrane] (Homo sapiens)
ADAM10/17 [plasma membrane] (Homo sapiens)
Signaling by NOTCH1 PEST Domain Mutants in Cancer (Homo sapiens)
Constitutive Signaling by NOTCH1 PEST Domain Mutants (Homo sapiens)
ADAM10/17 cleaves ligand-bound NOTCH1 PEST domain mutants to produce NEXT1 PEST domain mutants (Homo sapiens)
ADAM10/17:Zn2+ [plasma membrane] (Homo sapiens)
ADAM10/17 [plasma membrane] (Homo sapiens)
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant (Homo sapiens)
Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant (Homo sapiens)
NOTCH1 t(7;9)(NOTCH1:M1580_K2555) is cleaved to produce NEXT1 (Homo sapiens)
ADAM10/17:Zn2+ [plasma membrane] (Homo sapiens)
ADAM10/17 [plasma membrane] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by NOTCH (Homo sapiens)
Signaling by NOTCH1 (Homo sapiens)
Activated NOTCH1 Transmits Signal to the Nucleus (Homo sapiens)
Complex of NOTCH1 with its ligand is cleaved to produce NEXT1 (Homo sapiens)
ADAM10/17:Zn2+ [plasma membrane] (Homo sapiens)
ADAM10/17 [plasma membrane] (Homo sapiens)
Participants
members
ADAM10 [plasma membrane] (Homo sapiens)
candidates
ADAM17 [plasma membrane] (Homo sapiens)
Participant Of
hasComponent
ADAM10/17:Zn2+ [plasma membrane]
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