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active PDGF-BB dimer [extracellular region]
Stable Identifier
R-HSA-184206
Type
Complex
Species
Homo sapiens
Compartment
extracellular region
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
PI3K/AKT Signaling in Cancer (Homo sapiens)
Constitutive Signaling by Aberrant PI3K in Cancer (Homo sapiens)
PI3K inhibitors block PI3K catalytic activity (Homo sapiens)
PI3K Inhibitors:PI3K [cytosol] (Homo sapiens)
PI3K mutants,Activator:PI3K [plasma membrane] (Homo sapiens)
Activator:PI3K [plasma membrane] (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer:PI3K [plasma membrane] (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Homo sapiens)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Homo sapiens)
active PDGF-BB dimer [extracellular region] (Homo sapiens)
PI3K mutants,Activator:PI3K [plasma membrane] (Homo sapiens)
Activator:PI3K [plasma membrane] (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer:PI3K [plasma membrane] (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Homo sapiens)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Homo sapiens)
active PDGF-BB dimer [extracellular region] (Homo sapiens)
Hemostasis (Homo sapiens)
Platelet activation, signaling and aggregation (Homo sapiens)
Response to elevated platelet cytosolic Ca2+ (Homo sapiens)
Platelet degranulation (Homo sapiens)
Exocytosis of platelet alpha granule contents (Homo sapiens)
Platelet alpha granule contents [extracellular region] (Homo sapiens)
PDGF dimer [extracellular region] (Homo sapiens)
active PDGF-BB dimer [extracellular region] (Homo sapiens)
Signal Transduction (Homo sapiens)
Intracellular signaling by second messengers (Homo sapiens)
PIP3 activates AKT signaling (Homo sapiens)
Negative regulation of the PI3K/AKT network (Homo sapiens)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Homo sapiens)
PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
Activator:PI3K [plasma membrane] (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer:PI3K [plasma membrane] (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Homo sapiens)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Homo sapiens)
active PDGF-BB dimer [extracellular region] (Homo sapiens)
PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
Activator:PI3K [plasma membrane] (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer:PI3K [plasma membrane] (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Homo sapiens)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Homo sapiens)
active PDGF-BB dimer [extracellular region] (Homo sapiens)
MAPK family signaling cascades (Homo sapiens)
MAPK1/MAPK3 signaling (Homo sapiens)
RAF/MAP kinase cascade (Homo sapiens)
RAS GEFs promote RAS nucleotide exchange (Homo sapiens)
RAS GEFs [plasma membrane] (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer:Grb2:Sos1 [plasma membrane] (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Homo sapiens)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Homo sapiens)
active PDGF-BB dimer [extracellular region] (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by PDGF (Homo sapiens)
Autophosphorylation of PDGF alpha receptors (Homo sapiens)
PDGF alpha receptor: PDGF dimers [plasma membrane] (Homo sapiens)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Homo sapiens)
active PDGF-BB dimer [extracellular region] (Homo sapiens)
PDGFR:type I PDGFR-binding TKIs [plasma membrane] (Homo sapiens)
PDGF alpha receptor: PDGF dimers [plasma membrane] (Homo sapiens)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Homo sapiens)
active PDGF-BB dimer [extracellular region] (Homo sapiens)
Phospho PDGF alpha receptor:PDGF dimers [plasma membrane] (Homo sapiens)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Homo sapiens)
active PDGF-BB dimer [extracellular region] (Homo sapiens)
Autophosphorylation of PDGF alpha/beta receptors (Homo sapiens)
PDGF alpha/beta:PDGF AB and BB dimers [plasma membrane] (Homo sapiens)
PDGF AB or BB homodimers [extracellular region] (Homo sapiens)
active PDGF-BB dimer [extracellular region] (Homo sapiens)
Phospho PDGF alpha-beta dimer:PDGF AB or BB dimers [plasma membrane] (Homo sapiens)
PDGF AB or BB homodimers [extracellular region] (Homo sapiens)
active PDGF-BB dimer [extracellular region] (Homo sapiens)
Autophosphorylation of PDGF beta receptors (Homo sapiens)
PDGF beta receptor:PDGF chain B homodimer [plasma membrane] (Homo sapiens)
active PDGF-BB dimer [extracellular region] (Homo sapiens)
Phospho PDGF beta receptor: PDGF chain B homodimer [plasma membrane] (Homo sapiens)
active PDGF-BB dimer [extracellular region] (Homo sapiens)
active PDGF-BB dimer [extracellular region] (Homo sapiens)
Downstream signal transduction (Homo sapiens)
Activated PLC gamma dissociates from the PDGF receptor (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Homo sapiens)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Homo sapiens)
active PDGF-BB dimer [extracellular region] (Homo sapiens)
PDGF:p-PDGFR dimer:p-PLCgamma [plasma membrane] (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Homo sapiens)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Homo sapiens)
active PDGF-BB dimer [extracellular region] (Homo sapiens)
Activation of Src (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer:MyrG-SRC [plasma membrane] (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Homo sapiens)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Homo sapiens)
active PDGF-BB dimer [extracellular region] (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer:MyrG-p-Y419-SRC [plasma membrane] (Homo sapiens)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Homo sapiens)
active PDGF-BB dimer [extracellular region] (Homo sapiens)
Crk binds to the active PDGF receptor (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Homo sapiens)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Homo sapiens)
active PDGF-BB dimer [extracellular region] (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer:Crk [plasma membrane] (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Homo sapiens)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Homo sapiens)
active PDGF-BB dimer [extracellular region] (Homo sapiens)
GAP binds to PDGF-beta receptors only (Homo sapiens)
Phospho PDGF beta receptor: PDGF chain B homodimer [plasma membrane] (Homo sapiens)
active PDGF-BB dimer [extracellular region] (Homo sapiens)
Phospho-beta receptor homodimer:GAP [plasma membrane] (Homo sapiens)
Phospho PDGF beta receptor: PDGF chain B homodimer [plasma membrane] (Homo sapiens)
active PDGF-BB dimer [extracellular region] (Homo sapiens)
GRB2:SOS1 complex binds to the active receptor (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Homo sapiens)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Homo sapiens)
active PDGF-BB dimer [extracellular region] (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer:Grb2:Sos1 [plasma membrane] (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Homo sapiens)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Homo sapiens)
active PDGF-BB dimer [extracellular region] (Homo sapiens)
Grb7 binds to the active PDGF receptor (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Homo sapiens)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Homo sapiens)
active PDGF-BB dimer [extracellular region] (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer:Grb7 [plasma membrane] (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Homo sapiens)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Homo sapiens)
active PDGF-BB dimer [extracellular region] (Homo sapiens)
Nck binds to the active PDGF receptor (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Homo sapiens)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Homo sapiens)
active PDGF-BB dimer [extracellular region] (Homo sapiens)
PDGF:Phospho-PDGFR receptor dimer:Nck [plasma membrane] (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Homo sapiens)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Homo sapiens)
active PDGF-BB dimer [extracellular region] (Homo sapiens)
PI3-kinase binds to the active receptor (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Homo sapiens)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Homo sapiens)
active PDGF-BB dimer [extracellular region] (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer:PI3K [plasma membrane] (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Homo sapiens)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Homo sapiens)
active PDGF-BB dimer [extracellular region] (Homo sapiens)
PI3K catalyses the phosphorylation of PIP2 to PIP3 (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer:PI3K [plasma membrane] (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Homo sapiens)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Homo sapiens)
active PDGF-BB dimer [extracellular region] (Homo sapiens)
PLC-gamma binds to the active receptor (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Homo sapiens)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Homo sapiens)
active PDGF-BB dimer [extracellular region] (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer:PLC-gamma [plasma membrane] (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Homo sapiens)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Homo sapiens)
active PDGF-BB dimer [extracellular region] (Homo sapiens)
Phosphorylation of PLCgamma by PDGFR (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer:PLC-gamma [plasma membrane] (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Homo sapiens)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Homo sapiens)
active PDGF-BB dimer [extracellular region] (Homo sapiens)
PDGF:p-PDGFR dimer:p-PLCgamma [plasma membrane] (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Homo sapiens)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Homo sapiens)
active PDGF-BB dimer [extracellular region] (Homo sapiens)
SH2 domain of Src binds to the active receptor (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Homo sapiens)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Homo sapiens)
active PDGF-BB dimer [extracellular region] (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer:MyrG-SRC [plasma membrane] (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Homo sapiens)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Homo sapiens)
active PDGF-BB dimer [extracellular region] (Homo sapiens)
SHP2 binds to the active receptor (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Homo sapiens)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Homo sapiens)
active PDGF-BB dimer [extracellular region] (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer:SHP2 [plasma membrane] (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Homo sapiens)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Homo sapiens)
active PDGF-BB dimer [extracellular region] (Homo sapiens)
SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS) (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer:Grb2:Sos1 [plasma membrane] (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Homo sapiens)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Homo sapiens)
active PDGF-BB dimer [extracellular region] (Homo sapiens)
STAT binds to the active receptor (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Homo sapiens)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Homo sapiens)
active PDGF-BB dimer [extracellular region] (Homo sapiens)
PDGF:phospho-PDGF receptor dimer:STAT [plasma membrane] (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Homo sapiens)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Homo sapiens)
active PDGF-BB dimer [extracellular region] (Homo sapiens)
p130Cas and C3G bind PDGFR bound Crk (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer:Crk [plasma membrane] (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Homo sapiens)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Homo sapiens)
active PDGF-BB dimer [extracellular region] (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer:Crk:p130Cas:C3G [plasma membrane] (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer:Crk [plasma membrane] (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Homo sapiens)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Homo sapiens)
active PDGF-BB dimer [extracellular region] (Homo sapiens)
PDGF dimer binds two receptors simultaneously (Homo sapiens)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Homo sapiens)
active PDGF-BB dimer [extracellular region] (Homo sapiens)
PDGF:PDGF receptor dimer [plasma membrane] (Homo sapiens)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Homo sapiens)
active PDGF-BB dimer [extracellular region] (Homo sapiens)
PDGF-BB clevage by Furin (Homo sapiens)
active PDGF-BB dimer [extracellular region] (Homo sapiens)
PDGFRs bind type I TKI (Homo sapiens)
PDGF alpha receptor: PDGF dimers [plasma membrane] (Homo sapiens)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Homo sapiens)
active PDGF-BB dimer [extracellular region] (Homo sapiens)
PDGFR:type I PDGFR-binding TKIs [plasma membrane] (Homo sapiens)
PDGF alpha receptor: PDGF dimers [plasma membrane] (Homo sapiens)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Homo sapiens)
active PDGF-BB dimer [extracellular region] (Homo sapiens)
PTPN12 dephosphorylates PDGFRB at Y1021 (Homo sapiens)
p-PDGFRB homo and heterodimers [plasma membrane] (Homo sapiens)
Phospho PDGF alpha-beta dimer:PDGF AB or BB dimers [plasma membrane] (Homo sapiens)
PDGF AB or BB homodimers [extracellular region] (Homo sapiens)
active PDGF-BB dimer [extracellular region] (Homo sapiens)
Phospho PDGF beta receptor: PDGF chain B homodimer [plasma membrane] (Homo sapiens)
active PDGF-BB dimer [extracellular region] (Homo sapiens)
p-PDGFRB homo and heterodimers dephosphorylated at Y1021 [plasma membrane] (Homo sapiens)
Phospho PDGF alpha-beta dimer:PDGF AB or BB dimers dephosphorylated at Y1021 of PDGFRB [plasma membrane] (Homo sapiens)
PDGF AB or BB homodimers [extracellular region] (Homo sapiens)
active PDGF-BB dimer [extracellular region] (Homo sapiens)
Phospho PDGF beta receptor: PDGF chain B homodimer dephosphorylated at Y1021 [plasma membrane] (Homo sapiens)
active PDGF-BB dimer [extracellular region] (Homo sapiens)
Participants
components
x 2
Processed PDGF-B [extracellular region]
(Homo sapiens)
Participates
as a member of
PDGF dimer [extracellular region] (Homo sapiens)
PDGF AB or BB homodimers [extracellular region] (Homo sapiens)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Homo sapiens)
as a component of
Phospho PDGF beta receptor: PDGF chain B homodimer dephosphorylated at Y1021 [plasma membrane] (Homo sapiens)
Phospho PDGF beta receptor: PDGF chain B homodimer [plasma membrane] (Homo sapiens)
PDGF beta receptor:PDGF chain B homodimer [plasma membrane] (Homo sapiens)
as an output of
PDGF-BB clevage by Furin (Homo sapiens)
Inferred To
active PDGF-BB dimer [extracellular region]
(Bos taurus)
active PDGF-BB dimer [extracellular region]
(Caenorhabditis elegans)
active PDGF-BB dimer [extracellular region]
(Canis familiaris)
active PDGF-BB dimer [extracellular region]
(Danio rerio)
active PDGF-BB dimer [extracellular region]
(Drosophila melanogaster)
active PDGF-BB dimer [extracellular region]
(Gallus gallus)
active PDGF-BB dimer [extracellular region]
(Mus musculus)
active PDGF-BB dimer [extracellular region]
(Rattus norvegicus)
active PDGF-BB dimer [extracellular region]
(Sus scrofa)
active PDGF-BB dimer [extracellular region]
(Xenopus tropicalis)
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