Dissociation from the activated receptor quickly follows phosphorylation of PLC-gamma. Phosphorylated PLC-gamma catalyzes the hydrolysis of phosphatidylinositol(4, 5)bisphosphate to generate two second messengers, diacylglycerol and inositol (1,4,5) triphosphate.
Ji, Q, Carpenter, G
Gain of function of Activated FGFR1 mutants and fusion:p-PLCG1 [cytosol]
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