Cytosolic FGFR1 fusion protein-associated PI3K phosphorylates PIP2 to PIP3

Stable Identifier
R-HSA-1839091
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
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Cytosolic FGFR1 fusion protein-associated PI3K phosphorylates PIP2 to PIP3
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Once recruited to the activated receptor, PI3K phosphorylates PIP2 to PIP3, leading to activation of AKT signaling. PI3K signaling has been demonstrated in ZMYM2-, FOP- and BCR-FGFR1 fusions (Chen, 2004; Demiroglu, 2001; Guasch, 2001), as well as downstream of a number of other FGFR mutants (see for instance, Byron, 2008; Kunii, 2008; Agazie, 2003; Takeda, 2007).
Literature References
PubMed ID Title Journal Year
11689702 8p12 stem cell myeloproliferative disorder: the FOP-fibroblast growth factor receptor 1 fusion protein of the t(6;8) translocation induces cell survival mediated by mitogen-activated protein kinase and phosphatidylinositol 3-kinase/Akt/mTOR pathways

Guasch, G, Ollendorff, V, Borg, JP, Birnbaum, D, Pébusque, MJ

Mol Cell Biol 2001
11739186 The t(8;22) in chronic myeloid leukemia fuses BCR to FGFR1: transforming activity and specific inhibition of FGFR1 fusion proteins

Demiroglu, A, Steer, EJ, Heath, C, Taylor, K, Bentley, M, Allen, SL, Koduru, P, Brody, JP, Hawson, G, Rodwell, R, Doody, ML, Carnicero, F, Reiter, A, Goldman, JM, Melo, JV, Cross, NC

Blood 2001
15448205 PKC412 inhibits the zinc finger 198-fibroblast growth factor receptor 1 fusion tyrosine kinase and is active in treatment of stem cell myeloproliferative disorder

Chen, J, Deangelo, DJ, Kutok, JL, Williams, IR, Lee, BH, Wadleigh, M, Duclos, N, Cohen, S, Adelsperger, J, Okabe, R, Coburn, A, Galinsky, I, Huntly, B, Cohen, PS, Meyer, T, Fabbro, D, Roesel, J, Banerji, L, Griffin, JD, Xiao, S, Fletcher, JA, Stone, RM, Gilliland, DG

Proc Natl Acad Sci U S A 2004
Participants
Input
Output
Participates
as an event of
Catalyst Activity

1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity of p-FGFR1 mutant fusions:PI3K [cytosol]

Physical Entity
p-FGFR1 mutant fusions:PI3K [cytosol] (Homo sapiens)
Activity
1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity (GO:0046934)
Normal reaction
FGFR1-associated PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
Functional status

Gain of function of p-FGFR1 mutant fusions:PI3K [cytosol]

Normal Entity
Disease Entity
Status
Disease
Name Identifier Synonyms
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
Cross References
RHEA
Mondo
Authored
Rothfels, K  (2012-02-10)
Reviewed
Ezzat, S  (2012-05-15)
Created
Rothfels, K  (2011-10-27)
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