CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix

Stable Identifier
R-HSA-183084
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
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CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix
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Beta-Pix (Cool-1) associates with CBL, which appears to be a critical step in CDC42-mediated inhibition of EGFR ubiquitylation and downregulation. The SH3 domain of Beta-Pix specifically interacts with a proline-arginine motif (PxxxPR) present within CBL, which mediates ubiquitylation and subsequent degradation of Beta-Pix.

Literature References
PubMed ID Title Journal Year
16407834 Cbl escapes Cdc42-mediated inhibition by downregulation of the adaptor molecule betaPix

Schmidt, MH, Szymkiewicz, I, Husnjak, K, Dikic, I, Haglund, K

Oncogene 2006
Participants
Input
Output
Participates
as an event of
Catalyst Activity

ubiquitin-protein transferase activity of EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP [plasma membrane]

Physical Entity
EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP [plasma membrane] (Homo sapiens)
Activity
ubiquitin-protein transferase activity (GO:0004842)
Orthologous Events
CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix (Bos taurus)
CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix (Caenorhabditis elegans)
CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix (Canis familiaris)
CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix (Danio rerio)
CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix (Drosophila melanogaster)
CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix (Gallus gallus)
CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix (Mus musculus)
CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix (Rattus norvegicus)
CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix (Sus scrofa)
Authored
Castagnoli, L  (2006-10-10)
Reviewed
Heldin, CH  (2008-02-12)
Created
Jassal, B  (2006-07-21)
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