Phosphorylation of CBL (EGFR:GRB2:CBL)

Stable Identifier
R-HSA-183058
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
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Phosphorylation of CBL (EGFR:GRB2:CBL)
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EGF (and indeed FGF, PDGF and NGF) stimulation results in CBL phosphorylation on Tyr-371. Phosphorylation is necessary for CBL to exhibit ubiquitin ligase activity.

Literature References
Participants
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Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
protein tyrosine kinase activity of EGF-like ligands:p-6Y-EGFR:CBL:GRB2 [plasma membrane]
Physical Entity
EGF-like ligands:p-6Y-EGFR:CBL:GRB2 [plasma membrane]
Activity
protein tyrosine kinase activity (0004713)
Orthologous Events
Phosphorylation of CBL (EGFR:GRB2:CBL) (Bos taurus)
Phosphorylation of CBL (EGFR:GRB2:CBL) (Caenorhabditis elegans)
Phosphorylation of CBL (EGFR:GRB2:CBL) (Canis familiaris)
Phosphorylation of CBL (EGFR:GRB2:CBL) (Danio rerio)
Phosphorylation of CBL (EGFR:GRB2:CBL) (Drosophila melanogaster)
Phosphorylation of CBL (EGFR:GRB2:CBL) (Gallus gallus)
Phosphorylation of CBL (EGFR:GRB2:CBL) (Mus musculus)
Phosphorylation of CBL (EGFR:GRB2:CBL) (Rattus norvegicus)
Phosphorylation of CBL (EGFR:GRB2:CBL) (Sus scrofa)
Phosphorylation of CBL (EGFR:GRB2:CBL) (Xenopus tropicalis)
Authored
Castagnoli, L  (2006-10-10)
Reviewed
Heldin, CH  (2008-02-12)
Created
Jassal, B  (2006-07-21)