CBL ubiquitinates Sprouty

Stable Identifier
R-HSA-183051
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
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CBL ubiquitinates Sprouty
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Sprouty is ubiquitinated by CBL in an EGF-dependent manner. EGF stimulation induces the tyrosine phosphorylation of Sprouty, which in turn enhances the interaction of Sprouty with CBL. The CBL-mediated ubiquitination of Sprouty targets the protein for degradation by the 26S proteasome.

Literature References
PubMed ID Title Journal Year
12593796 hSpry2 is targeted to the ubiquitin-dependent proteasome pathway by c-Cbl

Hall, AB, Jura, N, DaSilva, J, Jang, YJ, Gong, D, Bar-Sagi, D

Curr Biol 2003
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
ubiquitin-protein transferase activity of EGF-like ligands:p-6Y-EGFR:CBL:p-Y53/55-SPRY1/2 [plasma membrane]
Physical Entity
EGF-like ligands:p-6Y-EGFR:CBL:p-Y53/55-SPRY1/2 [plasma membrane]
Activity
ubiquitin-protein transferase activity (0004842)
Orthologous Events
CBL ubiquitinates Sprouty (Bos taurus)
CBL ubiquitinates Sprouty (Caenorhabditis elegans)
CBL ubiquitinates Sprouty (Canis familiaris)
CBL ubiquitinates Sprouty (Danio rerio)
CBL ubiquitinates Sprouty (Drosophila melanogaster)
CBL ubiquitinates Sprouty (Gallus gallus)
CBL ubiquitinates Sprouty (Mus musculus)
CBL ubiquitinates Sprouty (Rattus norvegicus)
CBL ubiquitinates Sprouty (Sus scrofa)
CBL ubiquitinates Sprouty (Xenopus tropicalis)
Authored
Castagnoli, L  (2006-10-10)
Reviewed
Heldin, CH  (2008-02-12)
Created
Jassal, B  (2006-07-21)
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