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Sprouty sequesters CBL away from active EGFR
Stable Identifier
R-HSA-182990
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane
ReviewStatus
5/5
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Signal Transduction (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by EGFR (Homo sapiens)
EGFR downregulation (Homo sapiens)
Sprouty sequesters CBL away from active EGFR (Homo sapiens)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Sprouty can constitutively interact with two SH3 domains of CIN85 whereas the third SH3 domain of CIN85 can still associate with CBL on cell activation with EGF. This allows Sprouty to block CIN85-mediated clustering of CBL molecules, stablization of CBL-EGFR interactions and efficient ubiquitination and down-regulation of EGFR.
Literature References
PubMed ID
Title
Journal
Year
15962011
Sprouty2 acts at the Cbl/CIN85 interface to inhibit epidermal growth factor receptor downregulation
Schmidt, MH
,
Wong, ES
,
Dikic, I
,
Guy, GR
,
Haglund, K
EMBO Rep
2005
Participants
Input
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:CIN85:Endophilin:Epsin:Eps15L1:Eps15 [plasma membrane]
(Homo sapiens)
SPRY1/2 [plasma membrane]
(Homo sapiens)
Output
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:CIN85:SPRY1/2:Endophilin:Epsin:Eps15L1:EPS15 [plasma membrane]
(Homo sapiens)
Participates
as an event of
EGFR downregulation (Homo sapiens)
Orthologous Events
Sprouty sequesters CBL away from active EGFR (Bos taurus)
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Sprouty sequesters CBL away from active EGFR (Drosophila melanogaster)
Sprouty sequesters CBL away from active EGFR (Gallus gallus)
Sprouty sequesters CBL away from active EGFR (Mus musculus)
Sprouty sequesters CBL away from active EGFR (Rattus norvegicus)
Sprouty sequesters CBL away from active EGFR (Sus scrofa)
Authored
Castagnoli, L (2006-10-10)
Reviewed
Heldin, CH (2008-02-12)
Created
Jassal, B (2006-07-21)
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