Sprouty sequesters CBL away from active EGFR

Stable Identifier
R-HSA-182990
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane
ReviewStatus
5/5
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Sprouty sequesters CBL away from active EGFR
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Sprouty can constitutively interact with two SH3 domains of CIN85 whereas the third SH3 domain of CIN85 can still associate with CBL on cell activation with EGF. This allows Sprouty to block CIN85-mediated clustering of CBL molecules, stablization of CBL-EGFR interactions and efficient ubiquitination and down-regulation of EGFR.

Literature References
PubMed ID Title Journal Year
15962011 Sprouty2 acts at the Cbl/CIN85 interface to inhibit epidermal growth factor receptor downregulation

Schmidt, MH, Wong, ES, Dikic, I, Guy, GR, Haglund, K

EMBO Rep 2005
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Authored
Castagnoli, L  (2006-10-10)
Reviewed
Heldin, CH  (2008-02-12)
Created
Jassal, B  (2006-07-21)
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