CBL-mediated ubiquitination of CIN85

Stable Identifier
R-HSA-182986
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
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CBL-mediated ubiquitination of CIN85
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The adaptor protein CIN85 is monoubiquitinated by CBL after EGF stimulation. Monoubiquitination is thought to regulate receptor internalization and endosomal sorting.
Literature References
PubMed ID Title Journal Year
12218189 Cbl-directed monoubiquitination of CIN85 is involved in regulation of ligand-induced degradation of EGF receptors

Shimokawa, N, Szymkiewicz, I, Dikic, I, Haglund, K

Proc Natl Acad Sci U S A 2002
Participants
Input
Output
Participates
as an event of
Catalyst Activity

ubiquitin-protein transferase activity of EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:CIN85:Endophilin:Epsin:Eps15L1:Eps15 [plasma membrane]

Physical Entity
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:CIN85:Endophilin:Epsin:Eps15L1:Eps15 [plasma membrane] (Homo sapiens)
Activity
ubiquitin-protein transferase activity (GO:0004842)
Orthologous Events
CBL-mediated ubiquitination of CIN85 (Bos taurus)
CBL-mediated ubiquitination of CIN85 (Caenorhabditis elegans)
CBL-mediated ubiquitination of CIN85 (Canis familiaris)
CBL-mediated ubiquitination of CIN85 (Drosophila melanogaster)
CBL-mediated ubiquitination of CIN85 (Gallus gallus)
CBL-mediated ubiquitination of CIN85 (Mus musculus)
CBL-mediated ubiquitination of CIN85 (Rattus norvegicus)
CBL-mediated ubiquitination of CIN85 (Sus scrofa)
Authored
Castagnoli, L  (2006-10-10)
Reviewed
Heldin, CH  (2008-02-12)
Created
Jassal, B  (2006-07-21)
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