CBL-mediated ubiquitination of CIN85

Stable Identifier
R-HSA-182986
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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The adaptor protein CIN85 is monoubiquitinated by CBL after EGF stimulation. Monoubiquitination is thought to regulate receptor internalization and endosomal sorting.

Literature References
PubMed ID Title Journal Year
12218189 Cbl-directed monoubiquitination of CIN85 is involved in regulation of ligand-induced degradation of EGF receptors

Haglund, K, Shimokawa, N, Szymkiewicz, I, Dikic, I

Proc Natl Acad Sci U S A 2002
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
ubiquitin-protein transferase activity of EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:CIN85:Endophilin:Epsin:Eps15L1:Eps15 [plasma membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created