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p-Y55-SPRY2 [cytosol]
Stable Identifier
R-HSA-182950
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Y55-phospho Sprouty 2, hSpry2-phosphoY55
Locations in the PathwayBrowser for interactor UniProt:Q8NEC5 CATSPER1
Expand all
Signal Transduction (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by EGFR (Homo sapiens)
EGFR downregulation (Homo sapiens)
Sprouty lures CBL away from EGFR (Homo sapiens)
p-Y55-SPRY2 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:O43597 SPRY2
Gene Names
SPRY2
Chain
chain:1-315
Reference Genes
BioGPS Gene:10253 SPRY2
COSMIC (genes):SPRY2 SPRY2
CTD Gene:10253 SPRY2
dbSNP Gene:10253 SPRY2
ENSEMBL:ENSG00000136158 SPRY2
ENSEMBL_homo_sapiens_GENE:ENSG00000136158.12 SPRY2
HGNC:11270 SPRY2
KEGG Gene (Homo sapiens):10253 SPRY2
Monarch:10253 SPRY2
NCBI Gene:10253 SPRY2
OMIM:602466 SPRY2
UCSC:O43597 SPRY2
Reference Transcript
RefSeq:NM_001318536.1 SPRY2
RefSeq:NM_005842.3 SPRY2
RefSeq:NM_001318538.1 SPRY2
RefSeq:NM_001318537.1 SPRY2
Other Identifiers
10253
11753988_a_at
16780069
204011_PM_at
204011_at
33700_at
3519323
3519324
3519325
3519326
3519327
3519328
3519330
3519331
3519332
7972217
A_23_P128698
GE54345
GO:0000132
GO:0000278
GO:0005515
GO:0005634
GO:0005737
GO:0005829
GO:0005856
GO:0005874
GO:0005886
GO:0007010
GO:0007163
GO:0007275
GO:0007605
GO:0008285
GO:0008543
GO:0009966
GO:0010628
GO:0010719
GO:0010801
GO:0012501
GO:0015629
GO:0015630
GO:0016020
GO:0016525
GO:0019901
GO:0023052
GO:0030154
GO:0030291
GO:0030324
GO:0030335
GO:0030512
GO:0031345
GO:0031397
GO:0032587
GO:0033138
GO:0035924
GO:0036211
GO:0040037
GO:0042472
GO:0042995
GO:0043066
GO:0043226
GO:0043539
GO:0045165
GO:0045742
GO:0046580
GO:0048513
GO:0048754
GO:0048856
GO:0048870
GO:0050877
GO:0051387
GO:0051897
GO:0055105
GO:0060425
GO:0060437
GO:0060449
GO:0060541
GO:0070371
GO:0070373
GO:0070374
GO:0098772
GO:0140678
GO:1900747
GO:1902747
GO:1990752
GO:1990830
HMNXSV003025201
ILMN_2089329
PH_hs_0001652
TC13000763.hg
g5032114_3p_at
Participates
as an input of
Sprouty lures CBL away from EGFR (Homo sapiens)
as a member of
p-Y53/55-SPRY1/2 [cytosol] (Homo sapiens)
Other forms of this molecule
p-Y55,Y227-SPRY2 [plasma membrane]
p-S111,S120-SPRY2 [cytosol]
SPRY2 [plasma membrane]
SPRY2 [cytosol]
p-S112,S115-SPRY2 [cytosol]
p-Y55,Y227-SPRY2 [plasma membrane]
p-S112,S121-SPRY2 [plasma membrane]
Inferred To
phospho-spry2 [cytosol]
(Danio rerio)
phospho-spry2 [cytosol]
(Xenopus tropicalis)
phospho-p-Y55-SPRY2 [cytosol]
(Gallus gallus)
phospho-p-Y55-SPRY2 [cytosol]
(Sus scrofa)
phospho-sty [cytosol]
(Drosophila melanogaster)
phospho-Spry2 [cytosol]
(Mus musculus)
phospho-Spry2 [cytosol]
(Rattus norvegicus)
phospho-SPRY2 [cytosol]
(Bos taurus)
phospho-SPRY2 [cytosol]
(Canis familiaris)
Modified Residues
Name
O4'-phospho-L-tyrosine at 55
Coordinate
55
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Cross References
RefSeq
NP_001305465.1
,
NP_001305466.1
,
NP_001305467.1
,
NP_005833.1
OpenTargets
ENSG00000136158
GeneCards
O43597
HPA
ENSG00000136158-SPRY2
Ensembl
ENST00000377104
,
ENSP00000366308
,
ENSP00000366306
,
ENST00000377102
,
ENSG00000136158
PRO
O43597
Pharos - Targets
O43597
PDB
3BUM
,
5HL0
,
3OB1
,
5HKY
,
5HKZ
Interactors (66)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P22681 CBL
20
PolyUb,p-Y-CBL [cytosol]
(R-HSA-9763893)
CBL R420G [cytosol]
(R-HSA-9706203)
CBL R420Q [cytosol]
(R-HSA-9706186)
CBL Y371H [cytosol]
(R-HSA-9706680)
CBL H398Y [cytosol]
(R-HSA-9706639)
CBL P417A [cytosol]
(R-HSA-9706636)
CBL S376F [cytosol]
(R-HSA-9706643)
CBL E366_Q409del [cytosol]
(R-HSA-9706179)
CBL del366-477 [cytosol]
(R-HSA-9706176)
CBL R499L [cytosol]
(R-HSA-9706678)
CBL L380P [cytosol]
(R-HSA-9706630)
CBL L287R [cytosol]
(R-HSA-9706693)
CBL L380R [cytosol]
(R-HSA-9706635)
CBL G375P [cytosol]
(R-HSA-9706219)
CBL P417L [cytosol]
(R-HSA-9706634)
CBL H398Q [cytosol]
(R-HSA-9706633)
CBL P417R [cytosol]
(R-HSA-9706632)
CBL R499* [cytosol]
(R-HSA-9706670)
CBL H398R [cytosol]
(R-HSA-9706638)
CBL H398P [cytosol]
(R-HSA-9706637)
0.856
17
UniProt:Q5T7P3 LCE1B
1
LCE1B [cytosol]
(R-HSA-6814271)
0.742
5
UniProt:P57075 UBS3A
0.666
4
UniProt:Q9BQ66 KR412
0.666
4
UniProt:O43741 PRKAB2
2
PRKAB2 [cytosol]
(R-HSA-200413)
PRKAB2 [nucleoplasm]
(R-HSA-164096)
0.666
4
UniProt:Q8IUH5 ZDH17
0.666
4
UniProt:P32242 OTX1
0.666
4
UniProt:P62993 GRB2
1
GRB2 [cytosol]
(R-HSA-8983328)
0.591
3
UniProt:P26371 KRTAP5-9
1
KRTAP5-9 [cytosol]
(R-HSA-6810265)
0.556
3
UniProt:Q99750 MDFI
0.556
3
UniProt:Q5TA82 LCE2D
1
LCE2D [cytosol]
(R-HSA-6814300)
0.556
3
UniProt:Q9NVQ4 FAIM1
0.556
3
UniProt:Q12527
3
ATG11 [cytosol]
(R-SCE-5333627)
phospho-ATG11 [cytosol]
(R-SCE-5675845)
ATG11 [endoplasmic reticulum membrane]
(R-SCE-8948046)
0.556
3
UniProt:Q9BYR0 KRTAP4-7
1
KRTAP4-7 [cytosol]
(R-HSA-6809963)
0.556
3
UniProt:Q6P2C6 Q6P2C6
0.556
3
UniProt:Q9UJV3-2 MID2
0.556
3
UniProt:P07510-2 CHRNG
0.556
3
UniProt:Q9H2X0 CHRD
0.556
3
UniProt:Q8NEC5 CATSPER1
1
CATSPER1 [plasma membrane]
(R-HSA-2534335)
0.556
3
UniProt:Q5T5A8 LCE3C
1
LCE3C [cytosol]
(R-HSA-6814279)
0.556
3
UniProt:Q86UY0 Q86UY0
0.556
3
IntAct:EBI-16428938 CCSB ISOFORM ID
0.556
3
UniProt:Q9NUL5 SHFL
0.556
3
IntAct:EBI-10171679 386682
0.556
3
UniProt:P14770 GP9
1
GP9 [plasma membrane]
(R-HSA-55881)
0.556
3
UniProt:Q17RB8 LONRF1
1
LONRF1 [cytosol]
(R-HSA-8850905)
0.556
3
UniProt:Q02930-3 CREB5
0.556
3
UniProt:P32502
1
GCD7 [cytosol]
(R-SCE-72519)
0.556
3
UniProt:Q5JPT6 Q5JPT6
0.556
3
UniProt:Q06455-4 RUNX1T1
0.556
3
UniProt:Q8TF42 UBS3B
0.556
3
UniProt:Q5TA78 LCE4A
1
LCE4A [cytosol]
(R-HSA-6814272)
0.556
3
UniProt:Q12259 YL108
0.556
3
UniProt:Q9UKS6 PACSIN3
1
PACSIN3 [cytosol]
(R-HSA-8868270)
0.556
3
UniProt:Q96MH2 HEXI2
0.556
3
UniProt:O60336 MABP1
0.556
3
UniProt:P06782
5
PRKAA2 [nucleoplasm]
(R-SCE-163682)
PRKAA1 [cytosol]
(R-SCE-380935)
phospho-p-T183-PRKAA1 [cytosol]
(R-SCE-380964)
phospho-p-T172-PRKAA2 [cytosol]
(R-SCE-200417)
PRKAA2 [cytosol]
(R-SCE-200405)
0.556
3
UniProt:Q9Y4C2 TCAF1
0.556
3
UniProt:Q14847 LASP1
0.556
3
UniProt:Q9Y2K6 USP20
1
USP20 [cytosol]
(R-HSA-5696946)
0.556
3
UniProt:O75716 STK16
0.556
3
UniProt:O43559 FRS3
3
p-5Y-FRS3 [plasma membrane]
(R-HSA-191475)
FRS3 [plasma membrane]
(R-HSA-191482)
p-Y-FRS3 [plasma membrane]
(R-HSA-9032427)
0.556
3
UniProt:P29972 AQP1
1
AQP1 [plasma membrane]
(R-HSA-431700)
0.556
3
UniProt:Q9Y223 GNE
9
GNE V572L [cytosol]
(R-HSA-4088323)
GNE M712T [cytosol]
(R-HSA-4088386)
GNE R263L [cytosol]
(R-HSA-4088402)
GNE R266W [cytosol]
(R-HSA-4088372)
GNE R266Q [cytosol]
(R-HSA-4088390)
GNE A631V [cytosol]
(R-HSA-4088376)
GNE M171V [cytosol]
(R-HSA-4088351)
GNE C303V [cytosol]
(R-HSA-4088366)
GNE [cytosol]
(R-HSA-3781927)
0.556
3
IntAct:EBI-10173330 386677
0.556
3
UniProt:O60573 EIF4E2
1
EIF4E2 [cytosol]
(R-HSA-1678822)
0.556
3
UniProt:Q96SQ5 ZNF587
1
ZNF587 [nucleoplasm]
(R-HSA-2127565)
0.556
3
UniProt:P60412 KRTAP10-11
1
KRTAP10-11 [cytosol]
(R-HSA-6810243)
0.556
3
UniProt:P60410 KRTAP10-8
1
KRTAP10-8 [cytosol]
(R-HSA-6810301)
0.556
3
UniProt:P60411 KRTAP10-9
1
KRTAP10-9 [cytosol]
(R-HSA-6810277)
0.556
3
UniProt:P43115-12 PTGER3
0.556
3
UniProt:Q6L8G9 KRTAP5-6
1
KRTAP5-6 [cytosol]
(R-HSA-6810276)
0.556
3
UniProt:O43609 SPRY1
3
p-Y53-SPRY1 [cytosol]
(R-HSA-182933)
SPRY1 [plasma membrane]
(R-HSA-182944)
SPRY1 [cytosol]
(R-HSA-182908)
0.556
3
UniProt:P60370 KRTAP10-5
1
KRTAP10-5 [cytosol]
(R-HSA-6810260)
0.556
3
UniProt:Q9BYQ2 KRTAP9-4
1
KRTAP9-4 [cytosol]
(R-HSA-6809971)
0.556
3
UniProt:P28799 GRN
2
GRN [azurophil granule lumen]
(R-HSA-6799168)
GRN [extracellular region]
(R-HSA-6806217)
0.556
3
UniProt:Q5T5B0 LCE3E
1
LCE3E [cytosol]
(R-HSA-6814280)
0.556
3
UniProt:Q9BYQ6 KRTAP4-11
1
KRTAP4-11 [cytosol]
(R-HSA-6809960)
0.556
3
UniProt:P50222 MEOX2
0.556
3
UniProt:Q9H2F3 HSD3B7
1
HSD3B7 [endoplasmic reticulum membrane]
(R-HSA-193441)
0.556
3
UniProt:Q9BYQ4 KRTAP9-2
1
KRTAP9-2 [cytosol]
(R-HSA-6809965)
0.556
3
UniProt:Q8TAU3 ZNF417
1
ZNF417 [nucleoplasm]
(R-HSA-1247539)
0.556
3
UniProt:Q8WXE1 ATRIP
1
ATRIP [nucleoplasm]
(R-HSA-176231)
0.556
3
UniProt:O75791 GRAP2
1
GRAP2 [cytosol]
(R-HSA-202367)
0.556
3
UniProt:O43639 NCK2
1
NCK2 [cytosol]
(R-HSA-204885)
0.556
3
UniProt:Q96B97 SH3KBP1
3
SH3KBP1 [plasma membrane]
(R-HSA-182955)
SH3KBP1 [cytosol]
(R-HSA-182957)
Ub-SH3KBP1 [cytosol]
(R-HSA-182926)
0.499
2
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