Reactome | EPS15 [cytosol]

EPS15 [cytosol]

Stable Identifier

R-HSA-182920

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Eps15

Locations in the PathwayBrowser for interactor UniProt:P42566 EPS15

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External Reference Information

External Reference

UniProt:P42566 EPS15

Gene Names

EPS15, AF1P

Chain

initiator methionine:, chain:2-896

Reference Genes

BioGPS Gene:2060 EPS15

COSMIC (genes):EPS15 EPS15

CTD Gene:2060 EPS15

dbSNP Gene:2060 EPS15

ENSEMBL:ENSG00000085832 EPS15

ENSEMBL_homo_sapiens_GENE:ENSG00000085832.18 EPS15

HGNC:3419 EPS15

KEGG Gene (Homo sapiens):2060 EPS15

Monarch:2060 EPS15

NCBI Gene:2060 EPS15

OMIM:600051 EPS15

UCSC:P42566 EPS15

Reference Transcript

Other Identifiers

11719484_at

11719485_x_at

11719486_s_at

11750789_a_at

11751985_a_at

11756703_a_at

16687028

2060

217886_PM_at

217886_at

217887_PM_s_at

217887_s_at

2412361

2412362

2412363

2412364

2412365

2412368

2412369

2412370

2412371

2412372

2412387

2412389

2412390

2412392

2412394

2412395

2412397

2412398

2412399

2412400

2412401

2412402

2412406

2412408

2412410

2412413

2412418

2412419

2412420

2412422

2412423

2412424

2412428

2412441

2412442

37731_at

78641_at

7916045

A_23_P202

A_24_P28578

A_33_P3322328

GE60385

GO:0001921

GO:0005509

GO:0005515

GO:0005737

GO:0005768

GO:0005769

GO:0005829

GO:0005886

GO:0005905

GO:0006895

GO:0006897

GO:0009925

GO:0015031

GO:0016020

GO:0016050

GO:0016192

GO:0016197

GO:0016235

GO:0016324

GO:0017124

GO:0019065

GO:0023052

GO:0030132

GO:0031410

GO:0031593

GO:0031901

GO:0032456

GO:0042127

GO:0043226

GO:0043231

GO:0045202

GO:0045296

GO:0046718

GO:0046872

GO:0048268

GO:0065003

GO:0098794

GO:0098884

GO:0098978

HMNXSV003032069

Hs.79095.0.S2_3p_at

ILMN_1665357

PH_hs_0027703

TC01002649.hg

Z29064_at

g4503592_3p_a_at

Participates

as an output of

Dissociation of clathrin-associated proteins (Homo sapiens)

as a component of

as an input of

FCHo proteins bind nascent clathrin-coated pit (Homo sapiens)

as a member of

EPS15,EPN1,EPN2 [cytosol] (Homo sapiens)

Other forms of this molecule

p-Y849 EPS15 [cytosol]

Inferred To

EPS15 [cytosol] (Bos taurus)

EPS15 [cytosol] (Canis familiaris)

EPS15 [cytosol] (Gallus gallus)

EPS15 [cytosol] (Mus musculus)

EPS15 [cytosol] (Plasmodium falciparum)

EPS15 [cytosol] (Saccharomyces cerevisiae)

EPS15 [cytosol] (Schizosaccharomyces pombe)

EPS15 [cytosol] (Sus scrofa)

Eps15 [cytosol] (Rattus norvegicus)

Eps-15 [cytosol] (Drosophila melanogaster)

ehs-1 [cytosol] (Caenorhabditis elegans)

eps15 [cytosol] (Dictyostelium discoideum)

Cross References

RefSeq

NP_001153441.1, NP_001972.1

OpenTargets

ENSG00000085832

HPA

ENSG00000085832-EPS15

GeneCards

P42566

Ensembl

ENSP00000516332, ENSG00000085832, ENST00000493793, ENSP00000360798, ENST00000371733

PRO

P42566

Pharos - Targets

P42566

PDB

5JP2, 1FF1, 2JXC, 4RH9, 1EH2, 4RHG, 4RH5, 1F8H, 4S0G, 1C07, 5AWU, 5AWT, 2IV9

Interactors (34)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q8WXE9 STON2	2	NEDD8-STON2 [cytosol] (R-HSA-8863733) STON2 [cytosol] (R-HSA-8862856)	0.84	19
UniProt:P49757 NUMB	1	NUMB [plasma membrane] (R-HSA-443595)	0.75	6
UniProt:P53680 AP2S1	4	AP2S1 [cytosol] (R-HSA-182197) AP2S1 [clathrin-coated endocytic vesicle membrane] (R-HSA-2130707) AP2S1 [plasma membrane] (R-HSA-389382) AP2S1 [endolysosome membrane] (R-HSA-6784821)	0.725	6
UniProt:Q96CW1 AP2M1	6	AP2M1 [plasma membrane] (R-HSA-167585) AP2M1 [lysosomal membrane] (R-HSA-196144) AP2M1 [cytosol] (R-HSA-182227) AP2M1 [clathrin-coated endocytic vesicle membrane] (R-HSA-2130423) AP2M1 [endolysosome membrane] (R-HSA-6784828) p-T156 AP2M1 [cytosol] (R-HSA-8856805)	0.725	7
UniProt:Q9JJ50	1	HGS [cytosol] (R-RNO-182954)	0.72	5
UniProt:Q0JRZ9 FCHO2	1	FCHO2 [cytosol] (R-HSA-8862260)	0.695	4
UniProt:P52594 AGFG1	1	AGFG1 [cytosol] (R-HSA-8863714)	0.656	3
UniProt:P63010 AP2B1	4	AP2B1 [endolysosome membrane] (R-HSA-6784827) AP2B1 [plasma membrane] (R-HSA-167690) AP2B1 [clathrin-coated endocytic vesicle membrane] (R-HSA-2130489) AP2B1 [cytosol] (R-HSA-182166)	0.643	4
UniProt:P46108 CRK	1	CRK [cytosol] (R-HSA-2980677)	0.643	5
UniProt:P42566 EPS15	2	p-Y849 EPS15 [cytosol] (R-HSA-8867028) EPS15 [cytosol] (R-HSA-182920)	0.641	4
UniProt:Q9Y6I3 EPN1	2	EPN1 [plasma membrane] (R-HSA-182952) EPN1 [cytosol] (R-HSA-8865826)	0.623	2
UniProt:Q9P0V3 SH3BP4	1	SH3BP4 [cytosol] (R-HSA-8866227)	0.609	2
UniProt:Q13492 PICALM	3	PICALM [cytosol] (R-HSA-8867593) PICALM [cytoplasmic vesicle membrane] (R-HSA-429812) PICALM [Golgi membrane] (R-HSA-434341)	0.59	2
UniProt:Q15811 ITSN1	1	ITSN1 [cytosol] (R-HSA-3006481)	0.564	3
UniProt:Q3UQN2	1	Fcho2 [cytosol] (R-MMU-8862260)	0.557	3
UniProt:Q9UMX0 UBQLN1	1	UBQLN1 [cytosol] (R-HSA-8866006)	0.556	5
UniProt:Q9QYW3 PHOCN			0.544	2
UniProt:Q9QZS3-2 NUMB			0.539	3
UniProt:Q9QZS3-1 NUMB			0.539	3
UniProt:P09497 CLTB	5	CLTB [cytosol] (R-HSA-8856819) CLTB [trans-Golgi network membrane] (R-HSA-5333645) CLTB [clathrin-coated endocytic vesicle membrane] (R-HSA-5138428) CLTB [lysosomal membrane] (R-HSA-2980616) CLTB [plasma membrane] (R-HSA-2980617)	0.527	2
UniProt:O95782 AP2A1	5	AP2A1 [endolysosome membrane] (R-HSA-6784829) AP2A1 [endocytic vesicle membrane] (R-HSA-416641) AP2A1 [plasma membrane] (R-HSA-177494) AP2A1 [clathrin-coated endocytic vesicle membrane] (R-HSA-5138449) AP2A1 [cytosol] (R-HSA-182143)	0.527	2
UniProt:P55809 OXCT1	1	OXCT1 [mitochondrial matrix] (R-HSA-74317)	0.527	2
UniProt:O94973 AP2A2	6	AP2A2(1-939) [endolysosome membrane] (R-HSA-6784819) AP2A2(1-939) [ficolin-1-rich granule membrane] (R-HSA-6800414) AP2A2(1-939) [secretory granule membrane] (R-HSA-6800412) AP2A2(1-939) [plasma membrane] (R-HSA-177502) AP2A2(1-939) [clathrin-coated endocytic vesicle membrane] (R-HSA-5138448) AP2A2(1-939) [cytosol] (R-HSA-182155)	0.527	2
UniProt:Q96FJ0 STAMBPL1	1	STAMBPL1 [cytosol] (R-HSA-6783264)	0.527	2
UniProt:Q86X29 LSR	1	LSR [plasma membrane] (R-HSA-8933138)	0.527	2
UniProt:Q10567 AP1B1	5	AP1B1 [cytoplasmic vesicle membrane] (R-HSA-351181) AP1B1 [Golgi membrane] (R-HSA-350809) AP1B1 [lysosomal membrane] (R-HSA-432699) AP1B1 [trans-Golgi network membrane] (R-HSA-2130596) AP1B1 [cytosol] (R-HSA-167705)	0.527	2
UniProt:Q9HBM1 SPC25	1	SPC25 [cytosol] (R-HSA-375307)	0.527	4
UniProt:Q8N5S1 S2541			0.527	2
UniProt:P0C7W6 CC172			0.527	2
UniProt:Q9NVZ3 NECAP2	1	NECAP2 [cytosol] (R-HSA-8863466)	0.527	2
UniProt:O14965 AURKA	6	SUMO1-K258-AURKA [cytosol] (R-HSA-4655367) p-T288-AURKA [nucleoplasm] (R-HSA-6805089) PolyUb-AURKA [cytosol] (R-HSA-8854040) AURKA [nucleoplasm] (R-HSA-4655443) AURKA [cytosol] (R-HSA-174254) p-T288-AURKA [cytosol] (R-HSA-2574832)	0.527	3
UniProt:P19320 VCAM1	1	VCAM1 [plasma membrane] (R-HSA-197834)	0.527	4
UniProt:Q9UBC2 EPS15L1	2	EPS15L1 [plasma membrane] (R-HSA-182937) EPS15L1 [cytosol] (R-HSA-8935900)	0.527	3
UniProt:P98078-1 DAB2			0.463	2

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