Reactome | MASP1(449-699) [extracellular region]

MASP1(449-699) [extracellular region]

Stable Identifier

R-HSA-182686

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

MASP-1 light chain

Locations in the PathwayBrowser

Expand all

Immune System (Homo sapiens)

- Innate Immune System (Homo sapiens)
  - Complement cascade (Homo sapiens)
    - Initial triggering of complement (Homo sapiens)
      - Conversion of C2 into C2a and C2b (Homo sapiens)
        
        C4 activators [plasma membrane] (Homo sapiens)
        
        MBL2,FCN:activated MASPs:carbohydrate patterns [plasma membrane] (Homo sapiens)
        
        Ficolin-1:activated MASP-1:activated MASP-2:Ca2+:ficolin ligand [plasma membrane] (Homo sapiens)
        
        Activated MASP1 [extracellular region] (Homo sapiens)
        
        MASP1(449-699) [extracellular region] (Homo sapiens)
        
        Ficolin-2:activated MASP-1:activated MASP-2:Ca2+:ficolin ligand [plasma membrane] (Homo sapiens)
        
        Activated MASP1 [extracellular region] (Homo sapiens)
        
        MASP1(449-699) [extracellular region] (Homo sapiens)
        
        Ficolin-3:activated MASP-1:activated MASP-2:Ca2+:ficolin ligand [plasma membrane] (Homo sapiens)
        
        Activated MASP1 [extracellular region] (Homo sapiens)
        
        MASP1(449-699) [extracellular region] (Homo sapiens)
        
        MBL:activated MASPs:mannose-based carbohydrates [plasma membrane] (Homo sapiens)
        
        MBL2 dodecamer:2xActivated MASP1:2xActivated MASP2-1 [extracellular region] (Homo sapiens)
        
        Activated MASP1 [extracellular region] (Homo sapiens)
        
        MASP1(449-699) [extracellular region] (Homo sapiens)
      - Conversion of C4 into C4a and C4b (Homo sapiens)
        
        C4 activators [plasma membrane] (Homo sapiens)
        
        MBL2,FCN:activated MASPs:carbohydrate patterns [plasma membrane] (Homo sapiens)
        
        Ficolin-1:activated MASP-1:activated MASP-2:Ca2+:ficolin ligand [plasma membrane] (Homo sapiens)
        
        Activated MASP1 [extracellular region] (Homo sapiens)
        
        MASP1(449-699) [extracellular region] (Homo sapiens)
        
        Ficolin-2:activated MASP-1:activated MASP-2:Ca2+:ficolin ligand [plasma membrane] (Homo sapiens)
        
        Activated MASP1 [extracellular region] (Homo sapiens)
        
        MASP1(449-699) [extracellular region] (Homo sapiens)
        
        Ficolin-3:activated MASP-1:activated MASP-2:Ca2+:ficolin ligand [plasma membrane] (Homo sapiens)
        
        Activated MASP1 [extracellular region] (Homo sapiens)
        
        MASP1(449-699) [extracellular region] (Homo sapiens)
        
        MBL:activated MASPs:mannose-based carbohydrates [plasma membrane] (Homo sapiens)
        
        MBL2 dodecamer:2xActivated MASP1:2xActivated MASP2-1 [extracellular region] (Homo sapiens)
        
        Activated MASP1 [extracellular region] (Homo sapiens)
        
        MASP1(449-699) [extracellular region] (Homo sapiens)
      - Creation of C4 and C2 activators (Homo sapiens)
        
        Lectin pathway of complement activation (Homo sapiens)
        
        Activation of MASPs (Homo sapiens)
        
        MBL2,FCN:activated MASPs:carbohydrate patterns [plasma membrane] (Homo sapiens)
        
        Ficolin-1:activated MASP-1:activated MASP-2:Ca2+:ficolin ligand [plasma membrane] (Homo sapiens)
        
        Activated MASP1 [extracellular region] (Homo sapiens)
        
        MASP1(449-699) [extracellular region] (Homo sapiens)
        
        Ficolin-2:activated MASP-1:activated MASP-2:Ca2+:ficolin ligand [plasma membrane] (Homo sapiens)
        
        Activated MASP1 [extracellular region] (Homo sapiens)
        
        MASP1(449-699) [extracellular region] (Homo sapiens)
        
        Ficolin-3:activated MASP-1:activated MASP-2:Ca2+:ficolin ligand [plasma membrane] (Homo sapiens)
        
        Activated MASP1 [extracellular region] (Homo sapiens)
        
        MASP1(449-699) [extracellular region] (Homo sapiens)
        
        MBL:activated MASPs:mannose-based carbohydrates [plasma membrane] (Homo sapiens)
        
        MBL2 dodecamer:2xActivated MASP1:2xActivated MASP2-1 [extracellular region] (Homo sapiens)
        
        Activated MASP1 [extracellular region] (Homo sapiens)
        
        MASP1(449-699) [extracellular region] (Homo sapiens)

External Reference Information

External Reference

UniProt:P48740 MASP1

Gene Names

MASP1, CRARF, CRARF1, PRSS5

Chain

signal peptide:1-19, chain:20-699, chain:20-448, chain:449-699

Reference Genes

BioGPS Gene:5648 MASP1

COSMIC (genes):MASP1 MASP1

CTD Gene:5648 MASP1

dbSNP Gene:5648 MASP1

ENSEMBL:ENSG00000127241 MASP1

HGNC:6901 MASP1

KEGG:hsa:5648 MASP1

Monarch:5648 MASP1

NCBI Gene:5648 MASP1

OMIM:600521 MASP1

UCSC:P48740 MASP1

Reference Transcript

Participates

as a component of

Activated MASP1 [extracellular region] (Homo sapiens)

Other forms of this molecule

MASP1(20-448) [extracellular region]

MASP1(20-699) [extracellular region]

Inferred To

MASP1(449-699) [extracellular region] (Canis familiaris)

MASP1(449-699) [extracellular region] (Gallus gallus)

Masp1 [extracellular region] (Mus musculus)

Masp1 [extracellular region] (Rattus norvegicus)

masp1 [extracellular region] (Xenopus tropicalis)

MASP1 [extracellular region] (Bos taurus)

MASP1 [extracellular region] (Sus scrofa)

Cross References

RefSeq

XP_016862361.1, NP_001027019.1, NP_624302.1, NP_001870.3

OpenTargets

ENSG00000127241

ENSEMBL

ENSP00000296280, ENST00000296280, ENST00000337774, ENSP00000376264, ENSP00000169293, ENSG00000291559, ENSP00000336792, ENSP00000517064, ENSP00000517063, ENST00000707996, ENST00000707993, ENSP00000517062, ENSP00000517061, ENSG00000127241, ENST00000707994, ENST00000707990, ENST00000392472, ENST00000169293

HPA

ENSG00000127241-MASP1

GeneCards

MASP1

PRO

P48740

Pharos - Targets

P48740

Orphanet

MASP1

PDB

4DJZ, 4AQB, 4IGD, 4KKD, 3DEM, 4IW4, 3GOV, 7PQO