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MASP1(20-448) [extracellular region]
Stable Identifier
R-HSA-182685
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
MASP-1 heavy chain
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Complement cascade (Homo sapiens)
Initial triggering of complement (Homo sapiens)
Conversion of C2 into C2a and C2b (Homo sapiens)
C4 activators [plasma membrane] (Homo sapiens)
MBL2,FCN:activated MASPs:carbohydrate patterns [plasma membrane] (Homo sapiens)
Ficolin-1:activated MASP-1:activated MASP-2:Ca2+:ficolin ligand [plasma membrane] (Homo sapiens)
Activated MASP1 [extracellular region] (Homo sapiens)
MASP1(20-448) [extracellular region] (Homo sapiens)
Ficolin-2:activated MASP-1:activated MASP-2:Ca2+:ficolin ligand [plasma membrane] (Homo sapiens)
Activated MASP1 [extracellular region] (Homo sapiens)
MASP1(20-448) [extracellular region] (Homo sapiens)
Ficolin-3:activated MASP-1:activated MASP-2:Ca2+:ficolin ligand [plasma membrane] (Homo sapiens)
Activated MASP1 [extracellular region] (Homo sapiens)
MASP1(20-448) [extracellular region] (Homo sapiens)
MBL:activated MASPs:mannose-based carbohydrates [plasma membrane] (Homo sapiens)
MBL2 dodecamer:2xActivated MASP1:2xActivated MASP2-1 [extracellular region] (Homo sapiens)
Activated MASP1 [extracellular region] (Homo sapiens)
MASP1(20-448) [extracellular region] (Homo sapiens)
S3:M:E:encapsidated SARS-CoV-2 genomic RNA: 7a:O-glycosyl 3a tetramer:MBL2 dodecamer:MASP1 dimer:activate MASP2-1 dimer:Ca2+ [extracellular region] (Homo sapiens)
MBL2 dodecamer:2xActivated MASP1:2xActivated MASP2-1 [extracellular region] (Homo sapiens)
Activated MASP1 [extracellular region] (Homo sapiens)
MASP1(20-448) [extracellular region] (Homo sapiens)
Conversion of C4 into C4a and C4b (Homo sapiens)
C4 activators [plasma membrane] (Homo sapiens)
MBL2,FCN:activated MASPs:carbohydrate patterns [plasma membrane] (Homo sapiens)
Ficolin-1:activated MASP-1:activated MASP-2:Ca2+:ficolin ligand [plasma membrane] (Homo sapiens)
Activated MASP1 [extracellular region] (Homo sapiens)
MASP1(20-448) [extracellular region] (Homo sapiens)
Ficolin-2:activated MASP-1:activated MASP-2:Ca2+:ficolin ligand [plasma membrane] (Homo sapiens)
Activated MASP1 [extracellular region] (Homo sapiens)
MASP1(20-448) [extracellular region] (Homo sapiens)
Ficolin-3:activated MASP-1:activated MASP-2:Ca2+:ficolin ligand [plasma membrane] (Homo sapiens)
Activated MASP1 [extracellular region] (Homo sapiens)
MASP1(20-448) [extracellular region] (Homo sapiens)
MBL:activated MASPs:mannose-based carbohydrates [plasma membrane] (Homo sapiens)
MBL2 dodecamer:2xActivated MASP1:2xActivated MASP2-1 [extracellular region] (Homo sapiens)
Activated MASP1 [extracellular region] (Homo sapiens)
MASP1(20-448) [extracellular region] (Homo sapiens)
S3:M:E:encapsidated SARS-CoV-2 genomic RNA: 7a:O-glycosyl 3a tetramer:MBL2 dodecamer:MASP1 dimer:activate MASP2-1 dimer:Ca2+ [extracellular region] (Homo sapiens)
MBL2 dodecamer:2xActivated MASP1:2xActivated MASP2-1 [extracellular region] (Homo sapiens)
Activated MASP1 [extracellular region] (Homo sapiens)
MASP1(20-448) [extracellular region] (Homo sapiens)
Creation of C4 and C2 activators (Homo sapiens)
Lectin pathway of complement activation (Homo sapiens)
Activation of MASPs (Homo sapiens)
MBL2,FCN:activated MASPs:carbohydrate patterns [plasma membrane] (Homo sapiens)
Ficolin-1:activated MASP-1:activated MASP-2:Ca2+:ficolin ligand [plasma membrane] (Homo sapiens)
Activated MASP1 [extracellular region] (Homo sapiens)
MASP1(20-448) [extracellular region] (Homo sapiens)
Ficolin-2:activated MASP-1:activated MASP-2:Ca2+:ficolin ligand [plasma membrane] (Homo sapiens)
Activated MASP1 [extracellular region] (Homo sapiens)
MASP1(20-448) [extracellular region] (Homo sapiens)
Ficolin-3:activated MASP-1:activated MASP-2:Ca2+:ficolin ligand [plasma membrane] (Homo sapiens)
Activated MASP1 [extracellular region] (Homo sapiens)
MASP1(20-448) [extracellular region] (Homo sapiens)
MBL:activated MASPs:mannose-based carbohydrates [plasma membrane] (Homo sapiens)
MBL2 dodecamer:2xActivated MASP1:2xActivated MASP2-1 [extracellular region] (Homo sapiens)
Activated MASP1 [extracellular region] (Homo sapiens)
MASP1(20-448) [extracellular region] (Homo sapiens)
S3:M:E:encapsidated SARS-CoV-2 genomic RNA: 7a:O-glycosyl 3a tetramer:MBL2 dodecamer:MASP1 dimer:activate MASP2-1 dimer:Ca2+ [extracellular region] (Homo sapiens)
MBL2 dodecamer:2xActivated MASP1:2xActivated MASP2-1 [extracellular region] (Homo sapiens)
Activated MASP1 [extracellular region] (Homo sapiens)
MASP1(20-448) [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:P48740 MASP1
Gene Names
MASP1, CRARF, CRARF1, PRSS5
Chain
signal peptide:1-19, chain:20-699, chain:20-448, chain:449-699
Reference Genes
BioGPS Gene:5648 MASP1
COSMIC (genes):MASP1 MASP1
CTD Gene:5648 MASP1
dbSNP Gene:5648 MASP1
ENSEMBL:ENSG00000127241 MASP1
HGNC:6901 MASP1
KEGG:hsa:5648 MASP1
Monarch:5648 MASP1
NCBI Gene:5648 MASP1
OMIM:600521 MASP1
UCSC:P48740 MASP1
Reference Transcript
RefSeq:NM_001879.5 MASP1
RefSeq:NM_001031849.3 MASP1
RefSeq:NM_139125.4 MASP1
RefSeq:XM_017006872.1 MASP1
Participates
as a component of
Activated MASP1 [extracellular region] (Homo sapiens)
Other forms of this molecule
MASP1(449-699) [extracellular region]
MASP1(20-699) [extracellular region]
Cross References
RefSeq
NP_001027019.1
,
XP_016862361.1
,
NP_624302.1
,
NP_001870.3
OpenTargets
ENSG00000127241
ENSEMBL
ENSG00000291559
,
ENSP00000376264
,
ENST00000337774
,
ENST00000296280
,
ENSP00000336792
,
ENST00000707993
,
ENST00000707996
,
ENSP00000517061
,
ENSP00000517062
,
ENSP00000169293
,
ENSP00000296280
,
ENST00000707994
,
ENST00000707990
,
ENSP00000517063
,
ENSP00000517064
,
ENST00000392472
,
ENST00000169293
,
ENSG00000127241
HPA
ENSG00000127241-MASP1
GeneCards
MASP1
PRO
P48740
Pharos - Targets
P48740
Orphanet
MASP1
PDB
4IGD
,
4KKD
,
4DJZ
,
4AQB
,
7PQO
,
3GOV
,
3DEM
,
4IW4
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