Reactome | MASP1(20-448) [extracellular region]

MASP1(20-448) [extracellular region]

Stable Identifier

R-HSA-182685

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

MASP-1 heavy chain

Locations in the PathwayBrowser

Expand all

Immune System (Homo sapiens)

- Innate Immune System (Homo sapiens)
  - Complement cascade (Homo sapiens)
    - Initial triggering of complement (Homo sapiens)
      - Conversion of C2 into C2a and C2b (Homo sapiens)
        
        C4 activators [plasma membrane] (Homo sapiens)
        
        MBL2,FCN:activated MASPs:carbohydrate patterns [plasma membrane] (Homo sapiens)
        
        Ficolin-1:activated MASP-1:activated MASP-2:Ca2+:ficolin ligand [plasma membrane] (Homo sapiens)
        
        Activated MASP1 [extracellular region] (Homo sapiens)
        
        MASP1(20-448) [extracellular region] (Homo sapiens)
        
        Ficolin-2:activated MASP-1:activated MASP-2:Ca2+:ficolin ligand [plasma membrane] (Homo sapiens)
        
        Activated MASP1 [extracellular region] (Homo sapiens)
        
        MASP1(20-448) [extracellular region] (Homo sapiens)
        
        Ficolin-3:activated MASP-1:activated MASP-2:Ca2+:ficolin ligand [plasma membrane] (Homo sapiens)
        
        Activated MASP1 [extracellular region] (Homo sapiens)
        
        MASP1(20-448) [extracellular region] (Homo sapiens)
        
        MBL:activated MASPs:mannose-based carbohydrates [plasma membrane] (Homo sapiens)
        
        MBL2 dodecamer:2xActivated MASP1:2xActivated MASP2-1 [extracellular region] (Homo sapiens)
        
        Activated MASP1 [extracellular region] (Homo sapiens)
        
        MASP1(20-448) [extracellular region] (Homo sapiens)
      - Conversion of C4 into C4a and C4b (Homo sapiens)
        
        C4 activators [plasma membrane] (Homo sapiens)
        
        MBL2,FCN:activated MASPs:carbohydrate patterns [plasma membrane] (Homo sapiens)
        
        Ficolin-1:activated MASP-1:activated MASP-2:Ca2+:ficolin ligand [plasma membrane] (Homo sapiens)
        
        Activated MASP1 [extracellular region] (Homo sapiens)
        
        MASP1(20-448) [extracellular region] (Homo sapiens)
        
        Ficolin-2:activated MASP-1:activated MASP-2:Ca2+:ficolin ligand [plasma membrane] (Homo sapiens)
        
        Activated MASP1 [extracellular region] (Homo sapiens)
        
        MASP1(20-448) [extracellular region] (Homo sapiens)
        
        Ficolin-3:activated MASP-1:activated MASP-2:Ca2+:ficolin ligand [plasma membrane] (Homo sapiens)
        
        Activated MASP1 [extracellular region] (Homo sapiens)
        
        MASP1(20-448) [extracellular region] (Homo sapiens)
        
        MBL:activated MASPs:mannose-based carbohydrates [plasma membrane] (Homo sapiens)
        
        MBL2 dodecamer:2xActivated MASP1:2xActivated MASP2-1 [extracellular region] (Homo sapiens)
        
        Activated MASP1 [extracellular region] (Homo sapiens)
        
        MASP1(20-448) [extracellular region] (Homo sapiens)
      - Creation of C4 and C2 activators (Homo sapiens)
        
        Lectin pathway of complement activation (Homo sapiens)
        
        Activation of MASPs (Homo sapiens)
        
        MBL2,FCN:activated MASPs:carbohydrate patterns [plasma membrane] (Homo sapiens)
        
        Ficolin-1:activated MASP-1:activated MASP-2:Ca2+:ficolin ligand [plasma membrane] (Homo sapiens)
        
        Activated MASP1 [extracellular region] (Homo sapiens)
        
        MASP1(20-448) [extracellular region] (Homo sapiens)
        
        Ficolin-2:activated MASP-1:activated MASP-2:Ca2+:ficolin ligand [plasma membrane] (Homo sapiens)
        
        Activated MASP1 [extracellular region] (Homo sapiens)
        
        MASP1(20-448) [extracellular region] (Homo sapiens)
        
        Ficolin-3:activated MASP-1:activated MASP-2:Ca2+:ficolin ligand [plasma membrane] (Homo sapiens)
        
        Activated MASP1 [extracellular region] (Homo sapiens)
        
        MASP1(20-448) [extracellular region] (Homo sapiens)
        
        MBL:activated MASPs:mannose-based carbohydrates [plasma membrane] (Homo sapiens)
        
        MBL2 dodecamer:2xActivated MASP1:2xActivated MASP2-1 [extracellular region] (Homo sapiens)
        
        Activated MASP1 [extracellular region] (Homo sapiens)
        
        MASP1(20-448) [extracellular region] (Homo sapiens)

External Reference Information

External Reference

UniProt:P48740 MASP1

Gene Names

MASP1, CRARF, CRARF1, PRSS5

Chain

signal peptide:1-19, chain:20-699, chain:20-448, chain:449-699

Reference Genes

BioGPS Gene:5648 MASP1

COSMIC (genes):MASP1 MASP1

CTD Gene:5648 MASP1

dbSNP Gene:5648 MASP1

ENSEMBL:ENSG00000127241 MASP1

ENSEMBL_homo_sapiens_GENE:ENSG00000127241.18 MASP1

ENSEMBL_homo_sapiens_GENE:ENSG00000291559.1 MASP1

HGNC:6901 MASP1

KEGG Gene (Homo sapiens):5648 MASP1

Monarch:5648 MASP1

NCBI Gene:5648 MASP1

OMIM:600521 MASP1

UCSC:P48740 MASP1

Reference Transcript

Other Identifiers

11739111_at

11744244_a_at

11744245_x_at

11747974_a_at

11749805_a_at

11750715_a_at

11756901_a_at

16962536

206449_PM_s_at

206449_s_at

210680_PM_s_at

210680_s_at

213749_PM_at

213749_at

232224_PM_at

232224_at

2709636

2709637

2709638

2709639

2709640

2709641

2709642

2709643

2709644

2709645

2709646

2709647

2709648

2709652

2709654

2709656

2709657

2709658

2709659

2709660

2709661

2709664

2709666

2709668

2709669

2709670

2709673

2709675

2709677

2709680

2709681

2709683

2709695

2709696

2709697

2709698

33401_at

5648

8092661

82864_at

A_23_P212263

A_23_P397933

A_24_P41850

D17525_at

GE80559

GO:0001867

GO:0002376

GO:0003824

GO:0004252

GO:0005509

GO:0005515

GO:0005576

GO:0005615

GO:0005634

GO:0005654

GO:0005829

GO:0006508

GO:0006956

GO:0008233

GO:0008236

GO:0016787

GO:0031638

GO:0042802

GO:0042803

GO:0043226

GO:0045087

GO:0045916

GO:0046872

GO:0048306

GO:0051604

GO:0098542

GO:0140096

HMNXSV003022659

HMNXSV003023174

HMNXSV003050501

Hs.146001.0.S1_3p_at

Hs.227152.3.A1_3p_at

ILMN_1724300

ILMN_1785892

ILMN_1801996

ILMN_1809537

ILMN_1915166

ILMN_2240866

PH_hs_0022205

PH_hs_0031402

TC03002093.hg

TC03003257.hg

g439712_3p_a_at

g4505106_3p_a_at

Participates

as a component of

Activated MASP1 [extracellular region] (Homo sapiens)

Other forms of this molecule

MASP1(20-699) [extracellular region]

MASP1(449-699) [extracellular region]

Inferred To

MASP1(20-448) [extracellular region] (Bos taurus)

MASP1(20-448) [extracellular region] (Canis familiaris)

MASP1(20-448) [extracellular region] (Gallus gallus)

MASP1(20-448) [extracellular region] (Mus musculus)

MASP1(20-448) [extracellular region] (Rattus norvegicus)

MASP1(20-448) [extracellular region] (Sus scrofa)

MASP1(20-448) [extracellular region] (Xenopus tropicalis)

Cross References

RefSeq

XP_016862361.1, NP_624302.1, NP_001027019.1, NP_001870.3

OpenTargets

ENSG00000127241

GeneCards

P48740

HPA

ENSG00000127241-MASP1

Ensembl

ENSP00000296280, ENST00000169293, ENSP00000336792, ENST00000337774, ENST00000296280, ENSG00000127241, ENSP00000376264, ENST00000392472, ENSP00000169293

PRO

P48740

Pharos - Targets

P48740

Orphanet

19721

PDB

4IGD, 7PQO, 3GOV, 4DJZ, 4KKD, 4IW4, 3DEM, 4AQB

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