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CDKN1A [cytosol]
Stable Identifier
R-HSA-182512
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
p21, CIP1, WAF1
Icon
Locations in the PathwayBrowser for interactor UniProt:Q12834 CDC20
Expand all
Cell Cycle (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
Mitotic G1 phase and G1/S transition (Homo sapiens)
G1/S Transition (Homo sapiens)
Cyclin E associated events during G1/S transition (Homo sapiens)
Translocation of p21 to the nucleus (Homo sapiens)
CDKN1A [cytosol] (Homo sapiens)
Mitotic G2-G2/M phases (Homo sapiens)
G2/M Transition (Homo sapiens)
The role of GTSE1 in G2/M progression after G2 checkpoint (Homo sapiens)
GTSE1 binds CDKN1A (Homo sapiens)
CDKN1A [cytosol] (Homo sapiens)
S Phase (Homo sapiens)
Cyclin A:Cdk2-associated events at S phase entry (Homo sapiens)
Translocation of p21 to the nucleus (Homo sapiens)
CDKN1A [cytosol] (Homo sapiens)
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular response to chemical stress (Homo sapiens)
KEAP1-NFE2L2 pathway (Homo sapiens)
NFE2L2 binds KEAP1:NEDD8-CUL3:RBX1 (Homo sapiens)
CDKN1A [cytosol] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Neddylation (Homo sapiens)
NFE2L2 binds KEAP1:NEDD8-CUL3:RBX1 (Homo sapiens)
CDKN1A [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P38936 CDKN1A
Gene Names
CDKN1A, CAP20, CDKN1, CIP1, MDA6, PIC1, SDI1, WAF1
Chain
initiator methionine:, chain:2-164
Reference Genes
BioGPS Gene:1026 CDKN1A
COSMIC (genes):CDKN1A CDKN1A
CTD Gene:1026 CDKN1A
dbSNP Gene:1026 CDKN1A
ENSEMBL:ENSG00000124762 CDKN1A
ENSEMBL_homo_sapiens_GENE:ENSG00000124762.14 CDKN1A
HGNC:1784 CDKN1A
KEGG Gene (Homo sapiens):1026 CDKN1A
Monarch:1026 CDKN1A
NCBI Gene:1026 CDKN1A
OMIM:116899 CDKN1A
UCSC:P38936 CDKN1A
Reference Transcript
RefSeq:NM_001291549.1 CDKN1A
RefSeq:NM_001220777.1 CDKN1A
RefSeq:NM_001220778.1 CDKN1A
RefSeq:NM_078467.2 CDKN1A
RefSeq:NM_000389.4 CDKN1A
Other Identifiers
1026
11715387_at
11715388_s_at
17008007
202284_PM_s_at
202284_s_at
2031_s_at
2905173
2905175
2905176
2905177
2905178
2905183
2905184
2905189
2905193
2905194
2905195
8119088
A_23_P59210
A_24_P89457
GE58861
GO:0000079
GO:0000082
GO:0000278
GO:0000307
GO:0001701
GO:0001933
GO:0001934
GO:0002376
GO:0003824
GO:0004860
GO:0004861
GO:0005515
GO:0005634
GO:0005654
GO:0005730
GO:0005737
GO:0005829
GO:0006260
GO:0006606
GO:0006886
GO:0006913
GO:0006974
GO:0006977
GO:0006978
GO:0007049
GO:0007095
GO:0007265
GO:0007346
GO:0007507
GO:0008285
GO:0008544
GO:0009410
GO:0009411
GO:0009636
GO:0010033
GO:0010165
GO:0010243
GO:0010389
GO:0010629
GO:0012501
GO:0014070
GO:0016604
GO:0016740
GO:0019901
GO:0019912
GO:0023052
GO:0030154
GO:0030216
GO:0030308
GO:0030332
GO:0030890
GO:0031100
GO:0031625
GO:0031668
GO:0032091
GO:0032991
GO:0034198
GO:0034605
GO:0036211
GO:0042060
GO:0042246
GO:0042326
GO:0042771
GO:0043066
GO:0043068
GO:0043226
GO:0043616
GO:0044877
GO:0045740
GO:0045860
GO:0046685
GO:0046872
GO:0048144
GO:0048146
GO:0048471
GO:0048856
GO:0051384
GO:0051412
GO:0051726
GO:0055093
GO:0060574
GO:0070557
GO:0071479
GO:0071480
GO:0071493
GO:0072331
GO:0090398
GO:0090399
GO:0090400
GO:0090402
GO:0097193
GO:0098772
GO:0140096
GO:0140311
GO:0140313
GO:0140677
GO:0140678
GO:1902806
GO:1904030
GO:1904044
GO:1904706
GO:1905179
GO:2000045
GO:2000134
GO:2000278
GO:2000279
GO:2000379
HMNXSV003012106
ILMN_1784602
ILMN_1787212
PH_hs_0024155
U09579_at
g11386202_3p_a_at
Participates
as a member of
STAT3-upregulated cytosolic proteins [cytosol] (Homo sapiens)
CDKN1A,CDKN1B [cytosol] (Homo sapiens)
CDKN1A,CDKN1B,(CDKN1C) [cytosol] (Homo sapiens)
as a component of
GTSE1:CDKN1A:FKBPL:HSP90 [cytosol] (Homo sapiens)
as an input of
GTSE1 binds CDKN1A (Homo sapiens)
Translocation of p21 to the nucleus (Homo sapiens)
This entity regulates
Negatively
NFE2L2 binds KEAP1:NEDD8-CUL3:RBX1
(Homo sapiens)
Other forms of this molecule
p-T145-CDKN1A [cytosol]
p-Y77-CDKN1A [cytosol]
CDKN1A [nucleoplasm]
p-S130-CDKN1A [nucleoplasm]
Inferred To
CDKN1A [cytosol]
(Bos taurus)
CDKN1A [cytosol]
(Canis familiaris)
CDKN1A [cytosol]
(Gallus gallus)
CDKN1A [cytosol]
(Sus scrofa)
Cdkn1a [cytosol]
(Mus musculus)
Cdkn1a [cytosol]
(Rattus norvegicus)
Cross References
RefSeq
NP_001207706.1
,
NP_000380.1
,
NP_001207707.1
,
NP_510867.1
,
NP_001278478.1
OpenTargets
ENSG00000124762
ZINC - Substances
CDN1A_HUMAN
GeneCards
P38936
HPA
ENSG00000124762-CDKN1A
ZINC target
P38936
Ensembl
ENSG00000124762
,
ENSP00000244741
,
ENST00000405375
,
ENST00000244741
,
ENSP00000482768
,
ENSP00000384849
,
ENST00000373711
,
ENSP00000409259
,
ENST00000448526
,
ENST00000615513
,
ENSP00000362815
PRO
P38936
Pharos - Targets
P38936
Orphanet
20849
ZINC - Predictions - Purchasable
CDN1A_HUMAN
PDB
2ZVV
,
1AXC
,
7KQ0
,
5E0U
,
6CIX
,
6P8H
,
6CEJ
,
2ZVW
,
7KQ1
,
4RJF
,
6CIV
,
8GJF
,
6CBI
Interactors (67)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P12004 PCNA
5
monoSUMO1-K164,K254,K-PCNA [nucleoplasm]
(R-HSA-4615861)
K63polyUb-K164-PCNA [nucleoplasm]
(R-HSA-8943000)
ISG-K164,ISG-K168-PCNA [nucleoplasm]
(R-HSA-5653768)
MonoUb-K164-PCNA [nucleoplasm]
(R-HSA-5651986)
PCNA [nucleoplasm]
(R-HSA-68439)
0.977
39
UniProt:P24941 CDK2
5
p-Y15-CDK2 [nucleoplasm]
(R-HSA-187905)
p-CDK2 [nucleoplasm]
(R-HSA-68370)
CDK2 [cytosol]
(R-HSA-157440)
CDK2 [nucleoplasm]
(R-HSA-68365)
p-T160-CDK2 [nucleoplasm]
(R-HSA-187967)
0.976
32
UniProt:P30281 CCND3
2
CCND3 [cytosol]
(R-HSA-68333)
CCND3 [nucleoplasm]
(R-HSA-113835)
0.965
29
UniProt:P24385 CCND1
4
CCND1 [nucleoplasm]
(R-HSA-113832)
CCND1 [cytosol]
(R-HSA-68328)
p-T286-CCND1 [nucleoplasm]
(R-HSA-75811)
p-T286-CCND1 [cytosol]
(R-HSA-75813)
0.962
25
UniProt:P30279 CCND2
2
CCND2 [cytosol]
(R-HSA-68340)
CCND2 [nucleoplasm]
(R-HSA-113827)
0.95
19
UniProt:P11802 CDK4
3
CDK4 [cytosol]
(R-HSA-68330)
CDK4 [nucleoplasm]
(R-HSA-113843)
p-T172-CDK4 [nucleoplasm]
(R-HSA-113830)
0.926
10
UniProt:P06493 CDK1
11
CDK1 [endoplasmic reticulum membrane]
(R-HSA-264424)
p-Y4-CDK1 [cytosol]
(R-HSA-9836187)
p-T14,T161-CDK1 [nucleoplasm]
(R-HSA-170078)
p-T14-CDK1 [nucleoplasm]
(R-HSA-170045)
p-T14-CDK1 [cytosol]
(R-HSA-170064)
CDK1 [nucleoplasm]
(R-HSA-68889)
CDK1 [cytosol]
(R-HSA-170075)
p-T14,Y15,T161-CDK1 [cytosol]
(R-HSA-170071)
p-T161-CDK1 [cytosol]
(R-HSA-157415)
p-T14,Y15,T161-CDK1 [nucleoplasm]
(R-HSA-170074)
p-T161-CDK1 [nucleoplasm]
(R-HSA-170066)
0.903
10
UniProt:O96020 CCNE2
3
Unfolded CCNE2 [cytosol]
(R-HSA-6813844)
CCNE2 [cytosol]
(R-HSA-157452)
CCNE2 [nucleoplasm]
(R-HSA-68367)
0.888
8
UniProt:P24864 CCNE1
3
CCNE1 [nucleoplasm]
(R-HSA-68363)
CCNE1 [cytosol]
(R-HSA-157443)
Unfolded CCNE1 [cytosol]
(R-HSA-6813836)
0.853
11
UniProt:Q00526 CDK3
0.847
8
UniProt:Q00535 CDK5
4
CDK5 [nucleoplasm]
(R-HSA-8863586)
p-Y15,S159-CDK5 [nucleoplasm]
(R-HSA-6805249)
CDK5 [cytosol]
(R-HSA-180064)
p-Y15-CDK5 [cytosol]
(R-HSA-399809)
0.839
7
UniProt:P78396 CCNA1
3
PolyUb-CCNA1 [nucleoplasm]
(R-HSA-6783068)
CCNA1 [cytosol]
(R-HSA-157446)
CCNA1 [nucleoplasm]
(R-HSA-68891)
0.838
8
UniProt:P20248 CCNA2
3
PolyUb-CCNA2 [nucleoplasm]
(R-HSA-6783099)
CCNA2 [cytosol]
(R-HSA-157444)
CCNA2 [nucleoplasm]
(R-HSA-68905)
0.802
8
UniProt:P04637 TP53
20
Unfolded TP53 [cytosol]
(R-HSA-6813797)
TP53 [cytosol]
(R-HSA-8869337)
PolyUb-TP53 [nucleoplasm]
(R-HSA-6782509)
polySUMO2,3-K386-TP53 [nucleoplasm]
(R-HSA-2997661)
TP53 F341C [nucleoplasm]
(R-HSA-9726318)
TP53 G334V [nucleoplasm]
(R-HSA-9726126)
TP53 L330H [nucleoplasm]
(R-HSA-9726124)
TP53 A347T [nucleoplasm]
(R-HSA-9726339)
TP53 R337C [nucleoplasm]
(R-HSA-9726118)
TP53 L344P [nucleoplasm]
(R-HSA-9726075)
TP53 L344R [nucleoplasm]
(R-HSA-9726073)
TP53 R337H [nucleoplasm]
(R-HSA-9726169)
TP53 R337P [nucleoplasm]
(R-HSA-9726168)
TP53 L330P [nucleoplasm]
(R-HSA-9726136)
TP53 L348S [nucleoplasm]
(R-HSA-9726366)
TP53 R337L [nucleoplasm]
(R-HSA-9726163)
TP53 K351E [nucleoplasm]
(R-HSA-9726258)
TP53 F338I [nucleoplasm]
(R-HSA-9726358)
TP53 R342P [nucleoplasm]
(R-HSA-9726101)
TP53 L330R [nucleoplasm]
(R-HSA-9726133)
0.778
5
UniProt:O94921 CDK14
0.771
11
UniProt:Q13309 SKP2
3
SKP2 [cytosol]
(R-HSA-975495)
PolyUb-SKP2 [nucleoplasm]
(R-HSA-9687073)
SKP2 [nucleoplasm]
(R-HSA-975554)
0.731
4
UniProt:P14635 CCNB1
4
CCNB1 [nucleoplasm]
(R-HSA-68901)
p-4S-CCNB1 [cytosol]
(R-HSA-170058)
p-4S-CCNB1 [nucleoplasm]
(R-HSA-170049)
CCNB1 [cytosol]
(R-HSA-157451)
0.731
5
UniProt:Q15323 KRT31
1
KRT31 [cytosol]
(R-HSA-6809616)
0.718
6
UniProt:Q9BYV2 TRI54
0.718
6
UniProt:Q00534 CDK6
3
CDK6 [cytosol]
(R-HSA-68336)
CDK6 [nucleoplasm]
(R-HSA-141283)
p-T177-CDK6 [nucleoplasm]
(R-HSA-69628)
0.688
4
UniProt:Q7Z699 SPRED1
2
SPRED1 [plasma membrane]
(R-HSA-5658225)
SPRED1 [cytosol]
(R-HSA-5654207)
0.666
4
UniProt:Q8IYF3 TEX11
0.666
4
UniProt:P03129 VE7
0.656
6
UniProt:P61024 CKS1B
1
CKS1B [nucleoplasm]
(R-HSA-187533)
0.643
4
UniProt:Q9BQ15 NABP2
1
NABP2 [nucleoplasm]
(R-HSA-6814916)
0.619
7
UniProt:O95067 CCNB2
1
CCNB2 [cytosol]
(R-HSA-68897)
0.59
2
UniProt:Q99741 CDC6
4
CDC6 [nucleoplasm]
(R-HSA-68542)
p-CDC6 [nucleoplasm]
(R-HSA-5661317)
p-CDC6 [cytosol]
(R-HSA-68583)
CDC6 [cytosol]
(R-HSA-113566)
0.571
2
UniProt:O75419 CDC45
1
CDC45 [nucleoplasm]
(R-HSA-68563)
0.571
2
UniProt:O75460-2 ERN1
0.556
3
UniProt:Q6ZSJ9 SHSA6
0.556
3
UniProt:P22607 FGFR3
20
FGFR3(23-760)-TACC3(612-838) fusion [plasma membrane]
(R-HSA-8853144)
FGFR3(23-760)-BAIAP2L1(18-522) fusion [plasma membrane]
(R-HSA-8853131)
FGFR3(23-793)-TACC3(143-838) fusion [plasma membrane]
(R-HSA-8853152)
FGFR3(23-758)-TACC3(549-838) fusion [plasma membrane]
(R-HSA-8853124)
FGFR3(23-758)-TACC3(649-838) fusion [plasma membrane]
(R-HSA-8853125)
FGFR3(23-760)-TACC3(647-838) fusion [plasma membrane]
(R-HSA-8853127)
FGFR3 K650T [plasma membrane]
(R-HSA-1614411)
FGFR3 K650N [plasma membrane]
(R-HSA-1614406)
FGFR3 K650M [plasma membrane]
(R-HSA-1614402)
FGFR3 K650Q [plasma membrane]
(R-HSA-1614410)
FGFR3 A391E [plasma membrane]
(R-HSA-1614390)
FGFR3 K650E [plasma membrane]
(R-HSA-1614400)
FGFR3 G380R [plasma membrane]
(R-HSA-1614398)
FGFR3 G382D [plasma membrane]
(R-HSA-2018740)
FGFR3 805fs*141 [plasma membrane]
(R-HSA-1614387)
FGFR3 [plasma membrane]
(R-HSA-2038357)
FGFR3 S371C [plasma membrane]
(R-HSA-1614421)
FGFR3 Y373C [plasma membrane]
(R-HSA-1614424)
FGFR3 G370C [plasma membrane]
(R-HSA-1614394)
FGFR3 R248C [plasma membrane]
(R-HSA-1614419)
0.556
3
UniProt:P31321 PRKAR1B
2
PRKAR1B [cytosol]
(R-HSA-57838)
PRKAR1B [ciliary base]
(R-HSA-5610409)
0.556
3
UniProt:P41091 EIF2S3
1
EIF2S3 [cytosol]
(R-HSA-72514)
0.556
3
UniProt:Q9Y649 Q9Y649
0.556
3
UniProt:Q9BYR8 KRTAP3-1
1
KRTAP3-1 [cytosol]
(R-HSA-6809868)
0.556
3
UniProt:Q9UMX0 UBQLN1
1
UBQLN1 [cytosol]
(R-HSA-8866006)
0.556
3
UniProt:Q5JR59-3 MTUS2
0.556
3
UniProt:Q9P2M1 LR2BP
0.556
3
UniProt:Q9BVV2 FND11
0.556
3
UniProt:Q96ED9-2 HOOK2
0.556
3
UniProt:P51692 STAT5B
4
STAT5B [cytosol]
(R-HSA-380737)
p-Y699-STAT5B [cytosol]
(R-HSA-507939)
p-Y699-STAT5B [nucleoplasm]
(R-HSA-508016)
p-STAT5B [cytosol]
(R-HSA-8983127)
0.556
3
UniProt:P49591 SARS1
1
SARS [cytosol]
(R-HSA-379691)
0.556
3
UniProt:Q9UKT9 IKZF3
0.556
3
UniProt:Q0VDC6 Q0VDC6
0.556
3
UniProt:Q8N6Y0 USBP1
0.556
3
UniProt:P15884 TCF4
1
TCF4 [nucleoplasm]
(R-HSA-445672)
0.556
3
UniProt:Q04864-2 REL
0.556
3
UniProt:Q6FHY5 Q6FHY5
0.556
3
UniProt:G5E9A7 G5E9A7
0.556
3
UniProt:Q0VD86 INCA1
0.556
3
UniProt:Q9BVG8-5 KIFC3
0.556
3
UniProt:Q9BRK4 LZTS2
0.556
3
UniProt:P06396 GSN
7
GSN(200-270) [extracellular region]
(R-HSA-976940)
GSN [secretory granule lumen]
(R-HSA-6801486)
GSN [extracellular region]
(R-HSA-6806510)
GSN [ficolin-1-rich granule lumen]
(R-HSA-6801465)
GSN(404-782) [cytosol]
(R-HSA-350272)
GSN(28-403) [cytosol]
(R-HSA-201618)
GSN [cytosol]
(R-HSA-350275)
0.556
3
UniProt:Q9UBB9 TFIP11
1
TFIP11 [nucleoplasm]
(R-HSA-8869310)
0.556
3
UniProt:Q08379 GOLGA2
3
p-S37-GOLGA2 [Golgi membrane]
(R-HSA-2172179)
GOLGA2 [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-HSA-2167933)
GOLGA2 [Golgi membrane]
(R-HSA-6808764)
0.556
3
UniProt:Q13077 TRAF1
3
TRAF1 [cytosol]
(R-HSA-5634163)
TRAF1(1-163) [cytosol]
(R-HSA-5634199)
TRAF1(164-416) [cytosol]
(R-HSA-5634204)
0.556
3
UniProt:Q8NFF5 FLAD1
1
FLAD1 [cytosol]
(R-HSA-196980)
0.553
2
UniProt:P63208 SKP1
2
SKP1 [nucleoplasm]
(R-HSA-187538)
SKP1 [cytosol]
(R-HSA-174150)
0.536
3
UniProt:Q15004 PCLAF
2
KIAA0101 [nucleoplasm]
(R-HSA-5655178)
MonoUb-K15,K24-KIAA0101 [nucleoplasm]
(R-HSA-5655182)
0.527
2
UniProt:Q12834 CDC20
3
CDC20 [cytosol]
(R-HSA-141412)
CDC20 [nucleoplasm]
(R-HSA-174112)
PolyUb-CDC20 [nucleoplasm]
(R-HSA-6783069)
0.527
2
UniProt:Q9UQR0-1 SCML2
0.525
3
UniProt:Q9UHC7 MKRN1
2
MKRN1 [cytosol]
(R-HSA-976042)
p-S109-MKRN1 [cytosol]
(R-HSA-8948758)
0.524
5
UniProt:Q61187 Tsg101
2
Tsg101 [endosome membrane]
(R-MMU-9631185)
Tsg101 [endosome membrane]
(R-MMU-2980549)
0.508
3
UniProt:Q96FS4 SIPA1
1
SIPA1 [cytosol]
(R-HSA-392495)
0.508
2
UniProt:P27958-PRO_0000037566
0.499
3
UniProt:P35998 PSMC2
5
PSMC2 [secretory granule lumen]
(R-HSA-6800994)
PSMC2 [extracellular region]
(R-HSA-6806472)
PSMC2 [ficolin-1-rich granule lumen]
(R-HSA-6800421)
PSMC2 [nucleoplasm]
(R-HSA-174332)
PSMC2 [cytosol]
(R-HSA-68771)
0.488
2
UniProt:Q92793 CREBBP
4
monoSUMO1-K998,K1033,K1056-CREBBP [nucleoplasm]
(R-HSA-3927877)
FOXO4-S-S-CREBBP [nucleoplasm]
(R-HSA-9617684)
CREBBP [cytosol]
(R-HSA-9756493)
CREBBP [nucleoplasm]
(R-HSA-193545)
0.483
2
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