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HLA class I histocompatibility antigen, A-2 alpha chain [Golgi membrane]
Stable Identifier
R-HSA-182252
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
Golgi membrane
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
HIV Infection (Homo sapiens)
Host Interactions of HIV factors (Homo sapiens)
The role of Nef in HIV-1 replication and disease pathogenesis (Homo sapiens)
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters (Homo sapiens)
Nef mediated downregulation of MHC class I complex cell surface expression (Homo sapiens)
Formation of MHC I:Nef Complex (Homo sapiens)
Nef:class I MHC complex [Golgi membrane] (Homo sapiens)
class I MHC complex [Golgi membrane] (Homo sapiens)
HLA class I histocompatibility antigen, A-2 alpha chain [Golgi membrane] (Homo sapiens)
class I MHC complex [Golgi membrane] (Homo sapiens)
HLA class I histocompatibility antigen, A-2 alpha chain [Golgi membrane] (Homo sapiens)
Formation of MHC I:Nef:AP-1:PACS-1 Complex (Homo sapiens)
Nef:class I MHC complex [Golgi membrane] (Homo sapiens)
class I MHC complex [Golgi membrane] (Homo sapiens)
HLA class I histocompatibility antigen, A-2 alpha chain [Golgi membrane] (Homo sapiens)
Nef:class I MHC complex:Ap-1:PACS-1 Complex [Golgi membrane] (Homo sapiens)
class I MHC complex [Golgi membrane] (Homo sapiens)
HLA class I histocompatibility antigen, A-2 alpha chain [Golgi membrane] (Homo sapiens)
Transport of MHC I:Nef:AP-1:PACS-1 Complex (Homo sapiens)
Nef:class I MHC complex:Ap-1:PACS-1 Complex [Golgi membrane] (Homo sapiens)
class I MHC complex [Golgi membrane] (Homo sapiens)
HLA class I histocompatibility antigen, A-2 alpha chain [Golgi membrane] (Homo sapiens)
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Class I MHC mediated antigen processing & presentation (Homo sapiens)
Antigen Presentation: Folding, assembly and peptide loading of class I MHC (Homo sapiens)
Expression of peptide bound class I MHC on cell surface (Homo sapiens)
Antigen peptide bound class I MHC [Golgi membrane] (Homo sapiens)
monoglucosylated MHC class I HC [Golgi membrane] (Homo sapiens)
Class I MHC heavy chain (MHC HC) [Golgi membrane] (Homo sapiens)
HLA class I histocompatibility antigen, A-2 alpha chain [Golgi membrane] (Homo sapiens)
Journey of cargo through Golgi complex (Homo sapiens)
Antigen peptide bound class I MHC [Golgi membrane] (Homo sapiens)
monoglucosylated MHC class I HC [Golgi membrane] (Homo sapiens)
Class I MHC heavy chain (MHC HC) [Golgi membrane] (Homo sapiens)
HLA class I histocompatibility antigen, A-2 alpha chain [Golgi membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P01892 HLA-A
Gene Names
HLA-A, HLAA
Chain
signal peptide:1-24, chain:25-365
Reference Genes
BioGPS Gene:3105 HLA-A
COSMIC (genes):HLA-A HLA-A
CTD Gene:3105 HLA-A
dbSNP Gene:3105 HLA-A
ENSEMBL:ENSG00000206503 HLA-A
ENSEMBL:ENSG00000235657 HLA-A
KEGG Gene (Homo sapiens):3105 HLA-A
Monarch:3105 HLA-A
NCBI Gene:3105 HLA-A
OMIM:142800 HLA-A
UCSC:P01892 HLA-A
Reference Transcript
RefSeq:NM_001242758.1 HLA-A
RefSeq:NM_002116.7 HLA-A
Participates
as a component of
class I MHC complex [Golgi membrane] (Homo sapiens)
as a member of
Class I MHC heavy chain (MHC HC) [Golgi membrane] (Homo sapiens)
Other forms of this molecule
K48polyUb-HLA-A A-2 [endoplasmic reticulum membrane]
HLA-A A-2 [endoplasmic reticulum membrane]
HLA class I histocompatibility antigen, A-2 alpha chain [ER to Golgi transport vesicle membrane]
HLA class I histocompatibility antigen, A-2 alpha chain [phagocytic vesicle membrane]
HLA class I histocompatibility antigen, A-2 alpha chain [recycling endosome membrane]
HLA class I histocompatibility antigen, A-2 alpha chain [plasma membrane]
HLA class I histocompatibility antigen, A-2 alpha chain [early endosome membrane]
HLA class I histocompatibility antigen, A-2 alpha chain [integral component of lumenal side of endoplasmic reticulum membrane]
Cross References
RefSeq
NP_001229687.1
,
NP_002107.3
OpenTargets
ENSG00000206503
GeneCards
P01892
PRO
P01892
Pharos - Targets
P01892
PDB
4NO5
,
3FQU
,
1TMC
,
5F9J
,
3VXS
,
3MRB
,
5WWU
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3I6K
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5EU6
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2VLL
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3PWJ
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3W0W
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1I7R
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6PTB
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3H9S
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5D2L
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6SS8
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3GIV
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6J29
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1DUY
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2X4O
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1OGA
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3MRQ
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5BS0
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3D39
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1AQD
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5WKF
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1TVH
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5BRZ
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5HHO
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3GSN
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4NO0
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4MNQ
,
5TEZ
,
4OV5
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1T1Y
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1IM3
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2PYE
,
3MRF
,
4GKS
,
2X4S
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4JFE
,
5C07
,
5FA4
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1W72
,
5WSH
,
1QSE
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1T22
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3QDJ
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4U6X
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3GSR
,
3BO8
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1S9Y
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4N8V
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3O3B
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1HSB
,
5SWQ
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2X4N
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3KLA
,
3MRI
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3MGT
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4JFP
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6NCA
,
1BD2
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1HHH
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1I1F
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6APN
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3GSX
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2X70
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5NMG
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6ENY
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6AM5
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2GTZ
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4HWZ
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5C0E
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6RP9
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5HGD
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4UQ2
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3MRM
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3FT2
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5YXN
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3BH9
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1JF1
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3QDG
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2VLK
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5C0J
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3O4L
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4WU7
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5E9D
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5C0A
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1T1X
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3MR9
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3FQT
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1QRN
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3D25
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6SS7
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6J1W
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3HAE
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3I6G
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5HHN
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6Q3S
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1T21
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2F54
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1QVO
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5FA3
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2HLA
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5GRG
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2BNR
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4NNY
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6ID4
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6G3K
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3PWP
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5WWJ
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4JFD
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1TVB
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6D7G
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3MYJ
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6O9C
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4F7M
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5C0I
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1HHG
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3TO2
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6EWO
,
2BCK
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5WJN
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6JP3
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3HLA
,
4E5X
,
3QEQ
,
5W1W
,
5EOT
,
1S9X
,
2C7U
,
5E00
,
1LP9
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5MEQ
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6PBH
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3MGO
,
3O3A
,
2AV7
,
4I4W
,
1AO7
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3GSQ
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3MRH
,
4JFO
,
3QZW
,
5NMF
,
2GTW
,
1HHK
,
3MRP
,
5C0D
,
2JCC
,
4NQX
,
5WXD
,
3UTT
,
3BH8
,
4QOK
,
1EEZ
,
3MRL
,
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,
6MPP
,
3NFN
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2P5W
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,
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,
5IRO
,
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,
5FDW
,
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,
5HHQ
,
5N6B
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,
3MRK
,
6JOZ
,
2P5E
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,
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,
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,
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4EMZ
,
2GT9
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,
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,
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,
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,
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,
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,
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,
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,
3PWL
,
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,
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,
1I7T
,
2GUO
,
3FQW
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3I6L
,
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,
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,
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,
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,
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,
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,
1X7Q
,
5XOV
,
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,
4K7F
,
4EUP
,
3MRG
,
1T1Z
,
6EQA
,
5EU3
,
3H7B
,
4JFF
,
2AV1
,
4NO2
,
1QSF
,
3QDM
,
6RPB
,
2VLR
,
4HX1
,
5HHP
,
1S9W
,
5C08
,
3MRC
,
3VXU
,
2X4T
,
5WKH
,
5JZI
,
6AMT
,
5MEO
,
3O3D
,
5YXU
,
4L29
,
3UTQ
,
4U6Y
,
1I1Y
,
3MRJ
,
3GSU
,
4JFQ
,
6EI2
,
3MRR
,
1HHI
,
5D2N
,
3VXN
,
2CLR
,
2HN7
,
3QFJ
,
1AKJ
,
4FTV
,
1HLA
,
4F7T
,
3FQN
,
3WLB
,
4WUU
,
3BHB
,
5HGH
,
5C0F
,
1P7Q
,
3FT3
,
5NMH
,
4UQ3
,
3RL1
,
3MRN
,
3V5H
,
6EWA
,
1B0G
,
1JHT
,
6RPA
,
3HPJ
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P61769 B2M
11
B2M(21-119) [early endosome membrane]
(R-HSA-182298)
B2M(21-119) [ER to Golgi transport vesicle membrane]
(R-HSA-983378)
B2M(21-119) [Golgi membrane]
(R-HSA-983403)
B2M(21-119) [phagocytic vesicle membrane]
(R-HSA-1236891)
B2M(21-119) [recycling endosome membrane]
(R-HSA-8863880)
B2M(21-119) [early endosome lumen]
(R-HSA-1236827)
B2M(21-119) [specific granule lumen]
(R-HSA-6806144)
B2M(21-119) [extracellular region]
(R-HSA-1302721)
B2M(21-119) [tertiary granule lumen]
(R-HSA-6800179)
B2M(21-119) [endoplasmic reticulum lumen]
(R-HSA-983063)
B2M(21-119) [plasma membrane]
(R-HSA-167743)
0.713
20
UniProt:O15533 TAPBP
3
TAPBP [phagocytic vesicle membrane]
(R-HSA-1236750)
TAPBP [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-HSA-8863976)
TAPBP [integral component of lumenal side of endoplasmic reticulum membrane]
(R-HSA-983083)
0.688
10
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