Reactome | Toll Like Receptor 2 (TLR2) Cascade

Toll Like Receptor 2 (TLR2) Cascade

Stable Identifier

R-HSA-181438

Type

Pathway

Species

Homo sapiens

Related Species

Chlamydia trachomatis, Neisseria meningitidis serogroup B

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Click the image above or here to open this pathway in the Pathway Browser

TLR2 is involved in recognition of peptidoglycan from gram-positive bacteria, bacterial lipoproteins, mycoplasma lipoprotein and mycobacterial products. It is quite possible that recognition of at least some other TLR2 ligands may be assisted by additional accessory proteins, particularly in association with TLR1 or TLR6. TLR2 is expressed constitutively on macrophages, dendritic cells, and B cells, and can be induced in some other cell types, including epithelial cells. TLR1 and TLR6, on the other hand, are expressed almost ubiquitously (Muzio et al. 2000). TLR2 may be a sensor and inductor of specific defense processes, including oxidative stress and cellular necrosis initially spurred by microbial compounds.

Literature References

PubMed ID	Title	Journal	Year
10820283	Differential expression and regulation of toll-like receptors (TLR) in human leukocytes: selective expression of TLR3 in dendritic cells Muzio, M, Bosisio, D, Polentarutti, N, D'amico, G, Stoppacciaro, A, Mancinelli, R, van't Veer, C, Penton-Rol, G, Ruco, LP, Allavena, P, Mantovani, A	J Immunol	2000