Reactome | Association of Ran-GTP with importin-beta

Association of Ran-GTP with importin-beta

Stable Identifier

R-HSA-180728

Type

Reaction [binding]

Species

Homo sapiens

Related Species

Human immunodeficiency virus 1

Compartment

nucleoplasm

ReviewStatus

5/5

Locations in the PathwayBrowser

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Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Viral Infection Pathways (Homo sapiens)
    - HIV Infection (Homo sapiens)
      - Host Interactions of HIV factors (Homo sapiens)
        
        Interactions of Rev with host cellular proteins (Homo sapiens)
        
        Nuclear import of Rev protein (Homo sapiens)
        
        Association of Ran-GTP with importin-beta (Homo sapiens)

General

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Association of Ran-GTP with importin-beta

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Inside the nucleus, Ran-GTP associates with importin-beta.

Literature References

PubMed ID	Title	Journal	Year
9405152	Interactions between HIV Rev and nuclear import and export factors: the Rev nuclear localisation signal mediates specific binding to human importin-beta Henderson, BR, Percipalle, P	J Mol Biol	1997

Participants

Input

Output

Rev:importin-beta:B23:Ran-GTP complex [nucleoplasm] (Homo sapiens)

Participates

as an event of

Nuclear import of Rev protein (Homo sapiens)

Disease

Name	Identifier	Synonyms
Human immunodeficiency virus infectious disease	DOID:526	HIV infection

Authored

Matthews, L (2006-06-08)

Reviewed

Kumar, A (2007-02-01)

Created

Matthews, L (2006-06-02)

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