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PIP5K1B [cytosol]
Stable Identifier
R-HSA-1806216
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Phosphatidylinositol-4-phosphate 5-kinase type-1 beta, PI51B_HUMAN, STM7
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
Metabolism of lipids (Homo sapiens)
Phospholipid metabolism (Homo sapiens)
PI Metabolism (Homo sapiens)
Synthesis of PIPs at the plasma membrane (Homo sapiens)
PI is phosphorylated to PI5P by PIP5K1A/B at the plasma membrane (Homo sapiens)
PIP5K1A/B [cytosol] (Homo sapiens)
PIP5K1B [cytosol] (Homo sapiens)
PI(3,4)P2 is phosphorylated to PI(3,4,5)P3 by PIP5K1A-C at the plasma membrane (Homo sapiens)
PIP5K1A-C [cytosol] (Homo sapiens)
PIP5K1B [cytosol] (Homo sapiens)
PI3P is phosphorylated to PI(3,4)P2 by PIP4K2/5K1 at the plasma membrane (Homo sapiens)
PIP4K2/5K1 [cytosol] (Homo sapiens)
PIP5K1B [cytosol] (Homo sapiens)
PI3P is phosphorylated to PI(3,5)P2 by PIP5K1A/B at the plasma membrane (Homo sapiens)
PIP5K1A/B [cytosol] (Homo sapiens)
PIP5K1B [cytosol] (Homo sapiens)
PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane (Homo sapiens)
PIP5K1A-C [cytosol] (Homo sapiens)
PIP5K1B [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Intracellular signaling by second messengers (Homo sapiens)
PIP3 activates AKT signaling (Homo sapiens)
Negative regulation of the PI3K/AKT network (Homo sapiens)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Homo sapiens)
PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane (Homo sapiens)
PIP5K1A-C [cytosol] (Homo sapiens)
PIP5K1B [cytosol] (Homo sapiens)
Signaling by WNT (Homo sapiens)
TCF dependent signaling in response to WNT (Homo sapiens)
WNT mediated activation of DVL (Homo sapiens)
DVL-associated PIP5K1B phosphorylates PI4P to PI(4,5)P2 (Homo sapiens)
ppDVL:PIP5K1B [cytosol] (Homo sapiens)
PIP5K1B [cytosol] (Homo sapiens)
Phosphorylated DVL recruits PIP5K1B to the plasma membrane (Homo sapiens)
PIP5K1B [cytosol] (Homo sapiens)
ppDVL:PIP5K1B [cytosol] (Homo sapiens)
PIP5K1B [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:O14986 PIP5K1B
Gene Names
PIP5K1B, STM7
Chain
chain:1-540
Reference Genes
BioGPS Gene:8395 PIP5K1B
COSMIC (genes):PIP5K1B PIP5K1B
CTD Gene:8395 PIP5K1B
dbSNP Gene:8395 PIP5K1B
ENSEMBL:ENSG00000107242 PIP5K1B
HGNC:8995 PIP5K1B
KEGG:hsa:8395 PIP5K1B
Monarch:8395 PIP5K1B
NCBI Gene:8395 PIP5K1B
OMIM:602745 PIP5K1B
UCSC:O14986 PIP5K1B
Reference Transcript
RefSeq:XM_005252262.4 PIP5K1B
RefSeq:XM_017015189.1 PIP5K1B
RefSeq:XM_017015191.1 PIP5K1B
RefSeq:XM_017015190.1 PIP5K1B
RefSeq:XM_011519084.2 PIP5K1B
RefSeq:NM_003558.3 PIP5K1B
RefSeq:XM_006717301.1 PIP5K1B
RefSeq:NM_001278253.1 PIP5K1B
RefSeq:XM_011519083.2 PIP5K1B
RefSeq:XM_017015188.1 PIP5K1B
RefSeq:XM_005252261.3 PIP5K1B
RefSeq:XM_011519082.2 PIP5K1B
RefSeq:XM_006717300.2 PIP5K1B
Other Identifiers
11721029_a_at
11721030_a_at
11747546_a_at
17085635
205632_PM_s_at
205632_s_at
3173674
3173675
3173676
3173677
3173679
3173680
3173681
3173683
3173684
3173685
3173686
3173688
3173689
3173690
3173691
3173694
3173695
3173697
3173698
3173704
3173705
3173707
3173708
3173709
3173710
3173715
3173716
3173717
3173718
3173719
3173720
3173724
3173725
3173726
3173727
3173728
3173731
3173735
3173737
3173780
37253_at
8155673
8395
A_14_P121584
A_14_P122505
A_32_P465742
A_33_P3256725
GE60152
GE86468
GO:0000285
GO:0001931
GO:0003824
GO:0005515
GO:0005524
GO:0005737
GO:0005829
GO:0005886
GO:0006629
GO:0006661
GO:0012505
GO:0016301
GO:0016308
GO:0016740
GO:0046488
GO:0046854
GO:0051896
GO:0052742
GO:0052810
HMNXSV003031380
ILMN_1736654
ILMN_1738757
PH_hs_0023575
TC09000316.hg
X92493_s_at
g4505816_3p_a_at
Participates
as a component of
ppDVL:PIP5K1B [cytosol] (Homo sapiens)
as an input of
Phosphorylated DVL recruits PIP5K1B to the plasma membrane (Homo sapiens)
as a member of
PIP4K2/5K1 [cytosol] (Homo sapiens)
PIP5K1A/B [cytosol] (Homo sapiens)
PIP5K1A-C [cytosol] (Homo sapiens)
Inferred To
sktl [cytosol]
(Drosophila melanogaster)
PIPkinA [cytosol]
(Dictyostelium discoideum)
Homologues of PIP5K1B [cytosol]
(Dictyostelium discoideum)
Homologues of PIP5K1B [cytosol]
(Drosophila melanogaster)
PIP5K1B [cytosol]
(Bos taurus)
PIP5K1B [cytosol]
(Canis familiaris)
PIP5K1B [cytosol]
(Dictyostelium discoideum)
PIP5K1B [cytosol]
(Gallus gallus)
PIP5K1B [cytosol]
(Plasmodium falciparum)
PIP5K1B [cytosol]
(Sus scrofa)
Pip5k1b [cytosol]
(Mus musculus)
Pip5k1b [cytosol]
(Rattus norvegicus)
MSS4 [cytosol]
(Saccharomyces cerevisiae)
PIP5K59B [cytosol]
(Drosophila melanogaster)
its3 [cytosol]
(Schizosaccharomyces pombe)
ppk-1 [cytosol]
(Caenorhabditis elegans)
Cross References
RefSeq
XP_011517384.1
,
XP_016870678.1
,
XP_016870679.1
,
XP_016870677.1
,
NP_003549.1
,
XP_005252319.1
,
XP_006717363.1
,
NP_001265182.1
,
XP_016870680.1
,
XP_005252318.1
,
XP_006717364.1
,
XP_011517386.1
,
XP_011517385.1
Guide to Pharmacology - Targets
2500
OpenTargets
ENSG00000107242
ENSEMBL
ENSP00000435778
,
ENSG00000107242
,
ENSP00000265382
,
ENSP00000438082
,
ENST00000478500
,
ENST00000541509
,
ENST00000265382
IntEnz
2.7.1.68
HPA
ENSG00000107242-PIP5K1B
GeneCards
PIP5K1B
PRO
O14986
Pharos - Targets
O14986
HMDB Protein
HMDBP12145
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