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GRB2:Phospho-GAB1 [cytosol]
Stable Identifier
R-HSA-180304
Type
Complex
Species
Homo sapiens
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
PI3K/AKT Signaling in Cancer (Homo sapiens)
Constitutive Signaling by Aberrant PI3K in Cancer (Homo sapiens)
PI3K inhibitors block PI3K catalytic activity (Homo sapiens)
PI3K Inhibitors:PI3K [cytosol] (Homo sapiens)
PI3K mutants,Activator:PI3K [plasma membrane] (Homo sapiens)
Activator:PI3K [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:PI3K [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Homo sapiens)
GRB2:p-5Y-GAB1,GRB2:p-5Y-GAB1:PIP3 [cytosol] (Homo sapiens)
GRB2:Phospho-GAB1 [cytosol] (Homo sapiens)
GRB2:p-5Y-GAB1:PIP3 [plasma membrane] (Homo sapiens)
GRB2:Phospho-GAB1 [cytosol] (Homo sapiens)
PI3K mutants,Activator:PI3K [plasma membrane] (Homo sapiens)
Activator:PI3K [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:PI3K [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Homo sapiens)
GRB2:p-5Y-GAB1,GRB2:p-5Y-GAB1:PIP3 [cytosol] (Homo sapiens)
GRB2:Phospho-GAB1 [cytosol] (Homo sapiens)
GRB2:p-5Y-GAB1:PIP3 [plasma membrane] (Homo sapiens)
GRB2:Phospho-GAB1 [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Intracellular signaling by second messengers (Homo sapiens)
PIP3 activates AKT signaling (Homo sapiens)
Negative regulation of the PI3K/AKT network (Homo sapiens)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Homo sapiens)
PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
Activator:PI3K [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:PI3K [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Homo sapiens)
GRB2:p-5Y-GAB1,GRB2:p-5Y-GAB1:PIP3 [cytosol] (Homo sapiens)
GRB2:Phospho-GAB1 [cytosol] (Homo sapiens)
GRB2:p-5Y-GAB1:PIP3 [plasma membrane] (Homo sapiens)
GRB2:Phospho-GAB1 [cytosol] (Homo sapiens)
PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
Activator:PI3K [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:PI3K [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Homo sapiens)
GRB2:p-5Y-GAB1,GRB2:p-5Y-GAB1:PIP3 [cytosol] (Homo sapiens)
GRB2:Phospho-GAB1 [cytosol] (Homo sapiens)
GRB2:p-5Y-GAB1:PIP3 [plasma membrane] (Homo sapiens)
GRB2:Phospho-GAB1 [cytosol] (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by EGFR (Homo sapiens)
GAB1 signalosome (Homo sapiens)
Activation of SHP2 through the binding to phospho-Gab1 (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Homo sapiens)
GRB2:p-5Y-GAB1,GRB2:p-5Y-GAB1:PIP3 [cytosol] (Homo sapiens)
GRB2:Phospho-GAB1 [cytosol] (Homo sapiens)
GRB2:p-5Y-GAB1:PIP3 [plasma membrane] (Homo sapiens)
GRB2:Phospho-GAB1 [cytosol] (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Homo sapiens)
GRB2:p-5Y-GAB1,GRB2:p-5Y-GAB1:PIP3 [cytosol] (Homo sapiens)
GRB2:Phospho-GAB1 [cytosol] (Homo sapiens)
GRB2:p-5Y-GAB1:PIP3 [plasma membrane] (Homo sapiens)
GRB2:Phospho-GAB1 [cytosol] (Homo sapiens)
Dephosphorylation of Gab1 by SHP2 (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Homo sapiens)
GRB2:p-5Y-GAB1,GRB2:p-5Y-GAB1:PIP3 [cytosol] (Homo sapiens)
GRB2:Phospho-GAB1 [cytosol] (Homo sapiens)
GRB2:p-5Y-GAB1:PIP3 [plasma membrane] (Homo sapiens)
GRB2:Phospho-GAB1 [cytosol] (Homo sapiens)
Dephosphorylation of PAG by SHP2 (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Homo sapiens)
GRB2:p-5Y-GAB1,GRB2:p-5Y-GAB1:PIP3 [cytosol] (Homo sapiens)
GRB2:Phospho-GAB1 [cytosol] (Homo sapiens)
GRB2:p-5Y-GAB1:PIP3 [plasma membrane] (Homo sapiens)
GRB2:Phospho-GAB1 [cytosol] (Homo sapiens)
GAB1 phosphorylation by EGFR kinase (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Homo sapiens)
GRB2:p-5Y-GAB1,GRB2:p-5Y-GAB1:PIP3 [cytosol] (Homo sapiens)
GRB2:Phospho-GAB1 [cytosol] (Homo sapiens)
GRB2:p-5Y-GAB1:PIP3 [plasma membrane] (Homo sapiens)
GRB2:Phospho-GAB1 [cytosol] (Homo sapiens)
PI3K binds to EGF:EGFR:GRB2:GAB1 (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Homo sapiens)
GRB2:p-5Y-GAB1,GRB2:p-5Y-GAB1:PIP3 [cytosol] (Homo sapiens)
GRB2:Phospho-GAB1 [cytosol] (Homo sapiens)
GRB2:p-5Y-GAB1:PIP3 [plasma membrane] (Homo sapiens)
GRB2:Phospho-GAB1 [cytosol] (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:PI3K [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Homo sapiens)
GRB2:p-5Y-GAB1,GRB2:p-5Y-GAB1:PIP3 [cytosol] (Homo sapiens)
GRB2:Phospho-GAB1 [cytosol] (Homo sapiens)
GRB2:p-5Y-GAB1:PIP3 [plasma membrane] (Homo sapiens)
GRB2:Phospho-GAB1 [cytosol] (Homo sapiens)
PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:PI3K [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Homo sapiens)
GRB2:p-5Y-GAB1,GRB2:p-5Y-GAB1:PIP3 [cytosol] (Homo sapiens)
GRB2:Phospho-GAB1 [cytosol] (Homo sapiens)
GRB2:p-5Y-GAB1:PIP3 [plasma membrane] (Homo sapiens)
GRB2:Phospho-GAB1 [cytosol] (Homo sapiens)
SHP2 dephosphorylates Tyr 992 on EGFR (Homo sapiens)
EGF-like ligands:p-5Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] (Homo sapiens)
GRB2:p-5Y-GAB1,GRB2:p-5Y-GAB1:PIP3 [cytosol] (Homo sapiens)
GRB2:Phospho-GAB1 [cytosol] (Homo sapiens)
GRB2:p-5Y-GAB1:PIP3 [plasma membrane] (Homo sapiens)
GRB2:Phospho-GAB1 [cytosol] (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Homo sapiens)
GRB2:p-5Y-GAB1,GRB2:p-5Y-GAB1:PIP3 [cytosol] (Homo sapiens)
GRB2:Phospho-GAB1 [cytosol] (Homo sapiens)
GRB2:p-5Y-GAB1:PIP3 [plasma membrane] (Homo sapiens)
GRB2:Phospho-GAB1 [cytosol] (Homo sapiens)
Sustained activation of SRC kinase by SHP2 (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Homo sapiens)
GRB2:p-5Y-GAB1,GRB2:p-5Y-GAB1:PIP3 [cytosol] (Homo sapiens)
GRB2:Phospho-GAB1 [cytosol] (Homo sapiens)
GRB2:p-5Y-GAB1:PIP3 [plasma membrane] (Homo sapiens)
GRB2:Phospho-GAB1 [cytosol] (Homo sapiens)
Participants
components
GRB2-1 [cytosol] (Homo sapiens)
p-5Y-GAB1 [cytosol] (Homo sapiens)
Participant Of
hasComponent
GRB2:p-5Y-GAB1:PIP3 [plasma membrane]
hasMember
GRB2:p-5Y-GAB1,GRB2:p-5Y-GAB1:PIP3 [cytosol]
Inferred To
GRB2:Phospho-GAB1 [cytosol] (Caenorhabditis elegans)
GRB2:Phospho-GAB1 [cytosol] (Canis familiaris)
GRB2:Phospho-GAB1 [cytosol] (Danio rerio)
GRB2:Phospho-GAB1 [cytosol] (Drosophila melanogaster)
GRB2:Phospho-GAB1 [cytosol] (Gallus gallus)
GRB2:Phospho-GAB1 [cytosol] (Mus musculus)
GRB2:Phospho-GAB1 [cytosol] (Rattus norvegicus)
GRB2:Phospho-GAB1 [cytosol] (Sus scrofa)
GRB2:Phospho-GAB1 [cytosol] (Xenopus tropicalis)
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