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Pathway Diagrams
Icon Info
Data Model
Computational inferred events
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GRB2:Phospho-GAB1
Stable Identifier
R-HSA-180304
Type
Complex
Species
Homo sapiens
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of signal transduction (Homo sapiens)
PI3K/AKT Signaling in Cancer (Homo sapiens)
Constitutive Signaling by Aberrant PI3K in Cancer (Homo sapiens)
PI3K inhibitors block PI3K catalytic activity (Homo sapiens)
PI3K Inhibitors:PI3K [cytosol] (Homo sapiens)
PI3K mutants,Activator:PI3K [plasma membrane] (Homo sapiens)
Activator:PI3K [plasma membrane] (Homo sapiens)
EGF:p-6Y-EGFR:GRB2:p-5Y-GAB1:PI3K [plasma membrane] (Homo sapiens)
EGF:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Homo sapiens)
GRB2:p-5Y-GAB1,GRB2:p-5Y-GAB1:PIP3 [cytosol] (Homo sapiens)
GRB2:Phospho-GAB1 [cytosol] (Homo sapiens)
GRB2:p-5Y-GAB1:PIP3 [plasma membrane] (Homo sapiens)
GRB2:Phospho-GAB1 [cytosol] (Homo sapiens)
PI3K mutants,Activator:PI3K [plasma membrane] (Homo sapiens)
Activator:PI3K [plasma membrane] (Homo sapiens)
EGF:p-6Y-EGFR:GRB2:p-5Y-GAB1:PI3K [plasma membrane] (Homo sapiens)
EGF:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Homo sapiens)
GRB2:p-5Y-GAB1,GRB2:p-5Y-GAB1:PIP3 [cytosol] (Homo sapiens)
GRB2:Phospho-GAB1 [cytosol] (Homo sapiens)
GRB2:p-5Y-GAB1:PIP3 [plasma membrane] (Homo sapiens)
GRB2:Phospho-GAB1 [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Intracellular signaling by second messengers (Homo sapiens)
PIP3 activates AKT signaling (Homo sapiens)
Negative regulation of the PI3K/AKT network (Homo sapiens)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Homo sapiens)
PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
Activator:PI3K [plasma membrane] (Homo sapiens)
EGF:p-6Y-EGFR:GRB2:p-5Y-GAB1:PI3K [plasma membrane] (Homo sapiens)
EGF:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Homo sapiens)
GRB2:p-5Y-GAB1,GRB2:p-5Y-GAB1:PIP3 [cytosol] (Homo sapiens)
GRB2:Phospho-GAB1 [cytosol] (Homo sapiens)
GRB2:p-5Y-GAB1:PIP3 [plasma membrane] (Homo sapiens)
GRB2:Phospho-GAB1 [cytosol] (Homo sapiens)
PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
Activator:PI3K [plasma membrane] (Homo sapiens)
EGF:p-6Y-EGFR:GRB2:p-5Y-GAB1:PI3K [plasma membrane] (Homo sapiens)
EGF:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Homo sapiens)
GRB2:p-5Y-GAB1,GRB2:p-5Y-GAB1:PIP3 [cytosol] (Homo sapiens)
GRB2:Phospho-GAB1 [cytosol] (Homo sapiens)
GRB2:p-5Y-GAB1:PIP3 [plasma membrane] (Homo sapiens)
GRB2:Phospho-GAB1 [cytosol] (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by EGFR (Homo sapiens)
GAB1 signalosome (Homo sapiens)
Activation of SHP2 through the binding to phospho-Gab1 (Homo sapiens)
EGF:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Homo sapiens)
GRB2:p-5Y-GAB1,GRB2:p-5Y-GAB1:PIP3 [cytosol] (Homo sapiens)
GRB2:Phospho-GAB1 [cytosol] (Homo sapiens)
GRB2:p-5Y-GAB1:PIP3 [plasma membrane] (Homo sapiens)
GRB2:Phospho-GAB1 [cytosol] (Homo sapiens)
EGF:p-6Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] (Homo sapiens)
EGF:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Homo sapiens)
GRB2:p-5Y-GAB1,GRB2:p-5Y-GAB1:PIP3 [cytosol] (Homo sapiens)
GRB2:Phospho-GAB1 [cytosol] (Homo sapiens)
GRB2:p-5Y-GAB1:PIP3 [plasma membrane] (Homo sapiens)
GRB2:Phospho-GAB1 [cytosol] (Homo sapiens)
Dephosphorylation of Gab1 by SHP2 (Homo sapiens)
EGF:p-6Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] (Homo sapiens)
EGF:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Homo sapiens)
GRB2:p-5Y-GAB1,GRB2:p-5Y-GAB1:PIP3 [cytosol] (Homo sapiens)
GRB2:Phospho-GAB1 [cytosol] (Homo sapiens)
GRB2:p-5Y-GAB1:PIP3 [plasma membrane] (Homo sapiens)
GRB2:Phospho-GAB1 [cytosol] (Homo sapiens)
Dephosphorylation of PAG by SHP2 (Homo sapiens)
EGF:p-6Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] (Homo sapiens)
EGF:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Homo sapiens)
GRB2:p-5Y-GAB1,GRB2:p-5Y-GAB1:PIP3 [cytosol] (Homo sapiens)
GRB2:Phospho-GAB1 [cytosol] (Homo sapiens)
GRB2:p-5Y-GAB1:PIP3 [plasma membrane] (Homo sapiens)
GRB2:Phospho-GAB1 [cytosol] (Homo sapiens)
GAB1 phosphorylation by EGFR kinase (Homo sapiens)
EGF:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Homo sapiens)
GRB2:p-5Y-GAB1,GRB2:p-5Y-GAB1:PIP3 [cytosol] (Homo sapiens)
GRB2:Phospho-GAB1 [cytosol] (Homo sapiens)
GRB2:p-5Y-GAB1:PIP3 [plasma membrane] (Homo sapiens)
GRB2:Phospho-GAB1 [cytosol] (Homo sapiens)
PI3K binds to EGF:EGFR:GRB2:GAB1 (Homo sapiens)
EGF:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Homo sapiens)
GRB2:p-5Y-GAB1,GRB2:p-5Y-GAB1:PIP3 [cytosol] (Homo sapiens)
GRB2:Phospho-GAB1 [cytosol] (Homo sapiens)
GRB2:p-5Y-GAB1:PIP3 [plasma membrane] (Homo sapiens)
GRB2:Phospho-GAB1 [cytosol] (Homo sapiens)
EGF:p-6Y-EGFR:GRB2:p-5Y-GAB1:PI3K [plasma membrane] (Homo sapiens)
EGF:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Homo sapiens)
GRB2:p-5Y-GAB1,GRB2:p-5Y-GAB1:PIP3 [cytosol] (Homo sapiens)
GRB2:Phospho-GAB1 [cytosol] (Homo sapiens)
GRB2:p-5Y-GAB1:PIP3 [plasma membrane] (Homo sapiens)
GRB2:Phospho-GAB1 [cytosol] (Homo sapiens)
PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) (Homo sapiens)
EGF:p-6Y-EGFR:GRB2:p-5Y-GAB1:PI3K [plasma membrane] (Homo sapiens)
EGF:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Homo sapiens)
GRB2:p-5Y-GAB1,GRB2:p-5Y-GAB1:PIP3 [cytosol] (Homo sapiens)
GRB2:Phospho-GAB1 [cytosol] (Homo sapiens)
GRB2:p-5Y-GAB1:PIP3 [plasma membrane] (Homo sapiens)
GRB2:Phospho-GAB1 [cytosol] (Homo sapiens)
SHP2 dephosphorylates Tyr 992 on EGFR (Homo sapiens)
EGF:p-5Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] (Homo sapiens)
GRB2:p-5Y-GAB1,GRB2:p-5Y-GAB1:PIP3 [cytosol] (Homo sapiens)
GRB2:Phospho-GAB1 [cytosol] (Homo sapiens)
GRB2:p-5Y-GAB1:PIP3 [plasma membrane] (Homo sapiens)
GRB2:Phospho-GAB1 [cytosol] (Homo sapiens)
EGF:p-6Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] (Homo sapiens)
EGF:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Homo sapiens)
GRB2:p-5Y-GAB1,GRB2:p-5Y-GAB1:PIP3 [cytosol] (Homo sapiens)
GRB2:Phospho-GAB1 [cytosol] (Homo sapiens)
GRB2:p-5Y-GAB1:PIP3 [plasma membrane] (Homo sapiens)
GRB2:Phospho-GAB1 [cytosol] (Homo sapiens)
Sustained activation of SRC kinase by SHP2 (Homo sapiens)
EGF:p-6Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] (Homo sapiens)
EGF:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Homo sapiens)
GRB2:p-5Y-GAB1,GRB2:p-5Y-GAB1:PIP3 [cytosol] (Homo sapiens)
GRB2:Phospho-GAB1 [cytosol] (Homo sapiens)
GRB2:p-5Y-GAB1:PIP3 [plasma membrane] (Homo sapiens)
GRB2:Phospho-GAB1 [cytosol] (Homo sapiens)
Participants
components
GRB2-1 [cytosol] (Homo sapiens)
p-5Y-GAB1 [cytosol] (Homo sapiens)
Participant Of
hasMember
GRB2:p-5Y-GAB1,GRB2:p-5Y-GAB1:PIP3 [cytosol]
hasComponent
GRB2:p-5Y-GAB1:PIP3 [plasma membrane]
Inferred To
GRB2:Phospho-GAB1 [cytosol] (Bos taurus)
GRB2:Phospho-GAB1 [cytosol] (Canis familiaris)
GRB2:Phospho-GAB1 [cytosol] (Danio rerio)
GRB2:Phospho-GAB1 [cytosol] (Drosophila melanogaster)
GRB2:Phospho-GAB1 [cytosol] (Gallus gallus)
GRB2:Phospho-GAB1 [cytosol] (Mus musculus)
GRB2:Phospho-GAB1 [cytosol] (Rattus norvegicus)
GRB2:Phospho-GAB1 [cytosol] (Sus scrofa)
GRB2:Phospho-GAB1 [cytosol] (Taeniopygia guttata)
GRB2:Phospho-GAB1 [cytosol] (Xenopus tropicalis)
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