Reactome | DARPP-32 phosphorylated on Thr75 binds to PKA, inhibiting its function

DARPP-32 phosphorylated on Thr75 binds to PKA, inhibiting its function

Stable Identifier

R-HSA-180073

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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DARPP-32 phosphorylated on Thr75 binds to PKA, inhibiting its function

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DARPP-32 is converted into an inhibitor of protein kinase A (PKA) when phosphorylated at threonine 75 by cyclin-dependent kinase 5 (Cdk5) in brain cells.

Literature References

PubMed ID	Title	Journal	Year
10604473	Phosphorylation of DARPP-32 by Cdk5 modulates dopamine signalling in neurons Bibb, JA, Snyder, GL, Nishi, A, Yan, Z, Meijer, L, Fienberg, AA, Tsai, LH, Kwon, YT, Girault, JA, Czernik, AJ, Huganir, RL, Hemmings HC, Jr, Nairn, AC, Greengard, P	Nature	1999