Reactome | CDK5 phosphorylates DARPP-32 on Thr75

CDK5 phosphorylates DARPP-32 on Thr75

Stable Identifier

R-HSA-180047

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

Locations in the PathwayBrowser

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Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR downstream signalling (Homo sapiens)
    - G alpha (i) signalling events (Homo sapiens)
      - Opioid Signalling (Homo sapiens)
        
        DARPP-32 events (Homo sapiens)
        
        CDK5 phosphorylates DARPP-32 on Thr75 (Homo sapiens)

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The amino-acid sequence of DARPP-32 contains consensus phosphorylation sites for proline-directed kinases, including Cdk5, a cyclin-dependent kinase family member which is present in post-mitotic neurons expressing high levels of DARPP-32.

Literature References

PubMed ID	Title	Journal	Year
10604473	Phosphorylation of DARPP-32 by Cdk5 modulates dopamine signalling in neurons Snyder, GL, Hemmings HC, Jr, Tsai, LH, Girault, JA, Bibb, JA, Greengard, P, Meijer, L, Yan, Z, Huganir, RL, Czernik, AJ, Fienberg, AA, Nairn, AC, Kwon, YT, Nishi, A	Nature	1999