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p-T34,T75,S102-PPP1R1B [cytosol]
Stable Identifier
R-HSA-180033
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
p-S102,T34,T75-PPP1R1B, DARPP-32-T75P-S102P-T34P, Dopamine- and cAMP-regulated neuronal phosphoprotein
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (i) signalling events (Homo sapiens)
Opioid Signalling (Homo sapiens)
DARPP-32 events (Homo sapiens)
CDK5 phosphorylates DARPP-32 on Thr75 (Homo sapiens)
p-T75-DARPP32s [cytosol] (Homo sapiens)
p-T34,T75,S102-PPP1R1B [cytosol] (Homo sapiens)
DARPP-32 is dephosphorylated on Thr75 by PP2A (Homo sapiens)
p-T75-DARPP32s [cytosol] (Homo sapiens)
p-T34,T75,S102-PPP1R1B [cytosol] (Homo sapiens)
DARPP-32 phosphorylated on T34 binds to PP1, inhibiting its function (Homo sapiens)
DARPP-32 phosphorylated on T34 [cytosol] (Homo sapiens)
p-T34,T75,S102-PPP1R1B [cytosol] (Homo sapiens)
Phosphorylated (T34) DARPP-32:PP1A [cytosol] (Homo sapiens)
DARPP-32 phosphorylated on T34 [cytosol] (Homo sapiens)
p-T34,T75,S102-PPP1R1B [cytosol] (Homo sapiens)
DARPP-32 phosphorylated on Thr75 binds to PKA, inhibiting its function (Homo sapiens)
p-T75-DARPP32s [cytosol] (Homo sapiens)
p-T34,T75,S102-PPP1R1B [cytosol] (Homo sapiens)
p-T75-DARPP32s:PRKACA [cytosol] (Homo sapiens)
p-T75-DARPP32s [cytosol] (Homo sapiens)
p-T34,T75,S102-PPP1R1B [cytosol] (Homo sapiens)
PKA phosphorylates DARPP-32 on Thr34 (Homo sapiens)
DARPP-32 phosphorylated on T34 [cytosol] (Homo sapiens)
p-T34,T75,S102-PPP1R1B [cytosol] (Homo sapiens)
PKA phosphorylates PDE4B (Homo sapiens)
p-T75-DARPP32s [cytosol] (Homo sapiens)
p-T34,T75,S102-PPP1R1B [cytosol] (Homo sapiens)
PPP3 complex dephosphorylates DARPP-32 on Thr34 (Homo sapiens)
DARPP-32 phosphorylated on T34 [cytosol] (Homo sapiens)
p-T34,T75,S102-PPP1R1B [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9UD71 PPP1R1B
Gene Names
PPP1R1B, DARPP32
Chain
chain:1-204
Reference Genes
BioGPS Gene:84152 PPP1R1B
COSMIC (genes):PPP1R1B PPP1R1B
CTD Gene:84152 PPP1R1B
dbSNP Gene:84152 PPP1R1B
ENSEMBL:ENSG00000131771 PPP1R1B
ENSEMBL_homo_sapiens_GENE:ENSG00000131771.14 PPP1R1B
HGNC:9287 PPP1R1B
KEGG Gene (Homo sapiens):84152 PPP1R1B
Monarch:84152 PPP1R1B
NCBI Gene:84152 PPP1R1B
OMIM:604399 PPP1R1B
UCSC:Q9UD71 PPP1R1B
Reference Transcript
RefSeq:XM_017025216.1 PPP1R1B
RefSeq:NM_001242464.1 PPP1R1B
RefSeq:NM_181505.3 PPP1R1B
RefSeq:XM_017025217.1 PPP1R1B
RefSeq:NM_032192.3 PPP1R1B
Other Identifiers
11717061_a_at
16833787
225165_PM_at
225165_at
3720321
3720323
3720324
3720325
3720326
3720327
3720328
3720329
3720330
3720331
3720332
3720334
3720337
3720338
3720339
3720340
3720341
3720344
65792_at
8006865
84152
A_14_P115607
A_23_P129835
GE87420
GO:0001975
GO:0004860
GO:0004862
GO:0004864
GO:0005515
GO:0005634
GO:0005737
GO:0005829
GO:0006351
GO:0007165
GO:0007621
GO:0007626
GO:0008542
GO:0019888
GO:0022414
GO:0023052
GO:0032515
GO:0035556
GO:0036211
GO:0043025
GO:0043226
GO:0043278
GO:0048148
GO:0050877
GO:0071314
GO:0098772
HMNXSV003016473
Hs.286192.0.S1_3p_at
ILMN_1690096
ILMN_1759012
ILMN_2304495
PH_hs_0014802
TC17000477.hg
Participates
as a member of
p-T75-DARPP32s [cytosol] (Homo sapiens)
DARPP-32 phosphorylated on T34 [cytosol] (Homo sapiens)
Other forms of this molecule
PPP1R1B [cytosol]
p-S102,S137-PPP1R1B [cytosol]
p-S137-PPP1R1B [cytosol]
p-T75,S137-PPP1R1B [cytosol]
p-T75,S102,S137-PPP1R1B [cytosol]
p-T75-PPP1R1B [cytosol]
p-T75,S102-PPP1R1B [cytosol]
p-S102-PPP1R1B [cytosol]
p-T34,T75-PPP1R1B [cytosol]
p-T34,S102-PPP1R1B [cytosol]
p-T34,T75,S137-PPP1R1B [cytosol]
p-T34,S137-PPP1R1B [cytosol]
p-T34-PPP1R1B [cytosol]
p-T34,T75,S102,S137-PPP1R1B [cytosol]
p-T34,S102,S137-PPP1R1B [cytosol]
Inferred To
phospho-ppp1r1b [cytosol]
(Xenopus tropicalis)
phospho-p-T34,T75,S102-PPP1R1B [cytosol]
(Gallus gallus)
phospho-PPP1R1B [cytosol]
(Bos taurus)
phospho-PPP1R1B [cytosol]
(Canis familiaris)
phospho-PPP1R1B [cytosol]
(Sus scrofa)
phospho-Ppp1r1b [cytosol]
(Mus musculus)
phospho-Ppp1r1b [cytosol]
(Rattus norvegicus)
Modified Residues
Name
O-phospho-L-serine at 102
Coordinate
102
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-threonine at 75
Coordinate
75
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Name
O-phospho-L-threonine at 34
Coordinate
34
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Cross References
RefSeq
NP_852606.1
,
NP_001229393.1
,
XP_016880706.1
,
NP_115568.2
,
XP_016880705.1
OpenTargets
ENSG00000131771
GeneCards
Q9UD71
HPA
ENSG00000131771-PPP1R1B
Ensembl
ENSP00000254079
,
ENST00000580825
,
ENST00000394267
,
ENST00000394265
,
ENSP00000377810
,
ENSG00000131771
,
ENST00000254079
,
ENSP00000377808
,
ENSP00000462137
PRO
Q9UD71
Pharos - Targets
Q9UD71
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