APC-Cdc20 mediated degradation of Nek2A

Stable Identifier
R-HSA-179409
Type
Pathway
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this pathway in the Pathway Browser

Like Cyclin A, NIMA-related kinase 2A (Nek2A) is degraded during pro-metaphase in a checkpoint-independent manner.

Literature References
PubMed ID Title Journal Year
11742988 APC/C-mediated destruction of the centrosomal kinase Nek2A occurs in early mitosis and depends upon a cyclin A-type D-box

Fry, AM, Bacchieri, R, Yamano, H, Wattam, SL, Hames, RS

EMBO J 2001
16648845 Early mitotic degradation of Nek2A depends on Cdc20-independent interaction with the APC/C

Fry, AM, Mao, G, Kimata, Y, Hayes, MJ, Lindon, C, Yamano, H, Wattam, SL

Nat Cell Biol 2006
Participants
Participates
Event Information
Orthologous Events
Authored
Reviewed
Created
Cite Us!