HYAL1 hydrolyses Chondroitin chains

Stable Identifier
R-HSA-1793209
Type
Reaction [transition]
Species
Homo sapiens
Compartment
lysosomal lumen
ReviewStatus
5/5
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HYAL1 hydrolyses Chondroitin chains
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Hyaluronidase 1 (HYAL1) hydrolyses 1-4 linkages between GalNAc and D-glucuronate residues in chondroitin (or dermatan). It also hydrolyses this linkage in hyaluronate, another glycosaminoglycan (GAG) composed of repeating disaccharide units but the only one which is non-sulfated (Frost et al. 1997). There are five human hyaluronidases (HYALs, endo-beta-acetyl-hexosaminidases), HYAL1-4, and PH-20 (Jedrzejas & Stern 2005).

Literature References
PubMed ID Title Journal Year
9223416 Purification, cloning, and expression of human plasma hyaluronidase

Stern, R, Wong, T, Csóka, AB, Frost, GI

Biochem Biophys Res Commun 1997
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Catalyst Activity

hyalurononglucosaminidase activity of HYAL1-like proteins [lysosomal lumen]

Physical Entity
HYAL1-like proteins [lysosomal lumen] (Homo sapiens)
Activity
hyalurononglucosaminidase activity (GO:0004415)
Orthologous Events
HYAL1 hydrolyses Chondroitin chains (Bos taurus)
HYAL1 hydrolyses Chondroitin chains (Caenorhabditis elegans)
HYAL1 hydrolyses Chondroitin chains (Canis familiaris)
HYAL1 hydrolyses Chondroitin chains (Danio rerio)
HYAL1 hydrolyses Chondroitin chains (Gallus gallus)
HYAL1 hydrolyses Chondroitin chains (Mus musculus)
HYAL1 hydrolyses Chondroitin chains (Rattus norvegicus)
HYAL1 hydrolyses Chondroitin chains (Sus scrofa)
HYAL1 hydrolyses Chondroitin chains (Xenopus tropicalis)
Authored
Jassal, B  (2011-10-21)
Reviewed
D'Eustachio, P  (2012-03-28)
Created
Jassal, B  (2011-10-21)
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