HYAL1 hydrolyses Chondroitin chains

Stable Identifier
R-HSA-1793209
Type
Reaction
Species
Homo sapiens
Compartment
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Hyaluronidase 1 (HYAL1) hydrolyses 1-4 linkages between GalNAc and D-glucuronate residues in chondroitin (or dermatan). It also hydrolyses this linkage in hyaluronate, another glycosaminoglycan (GAG) composed of repeating disaccharide units but the only one which is non-sulfated (Frost et al. 1997). There are five human hyaluronidases (HYALs, endo-beta-acetyl-hexosaminidases), HYAL1-4, and PH-20 (Jedrzejas & Stern 2005).

Literature References
PubMed ID Title Journal Year
9223416 Purification, cloning, and expression of human plasma hyaluronidase

Stern, R, Wong, T, Csóka, AB, Frost, GI

Biochem Biophys Res Commun 1997
Participants
Participates
Catalyst Activity

hyalurononglucosaminidase activity of HYAL1-like proteins [lysosomal lumen]

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