HYAL1 hydrolyses Chondroitin chains

Stable Identifier
R-HSA-1793209
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Hyaluronidase 1 (HYAL1) hydrolyses 1-4 linkages between GalNAc and D-glucuronate residues in chondroitin (or dermatan). It also hydrolyses this linkage in hyaluronate, another glycosaminoglycan (GAG) composed of repeating disaccharide units but the only one which is non-sulfated (Frost et al. 1997). There are five human hyaluronidases (HYALs, endo-beta-acetyl-hexosaminidases), HYAL1-4, and PH-20 (Jedrzejas & Stern 2005).

Literature References
PubMed ID Title Journal Year
9223416 Purification, cloning, and expression of human plasma hyaluronidase

Frost, GI, Csóka, AB, Wong, T, Stern, R

Biochem Biophys Res Commun 1997
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
hyalurononglucosaminidase activity of HYAL1-like proteins [lysosomal lumen]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created