DS is cleaved from its proteoglycan

Stable Identifier
R-HSA-1793176
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
lysosomal lumen
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DS is cleaved from its proteoglycan
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Dermatan sulfate (DS) is thought to be hydrolysed from its dermatan sulfate proteoglycan (DSPG) by an unknown human beta-xylosidase. The reaction shown here is based on studies of a rabbit lysosomal enzyme fraction assay (Takagaki et al. 1988). DSPG can have many DS chains attached to it; this example shows the hydrolysis of one DS chain from DSPG.

Literature References
PubMed ID Title Journal Year
3134052 Demonstration of an endo-beta-galactosidase and an endo-beta-xylosidase that degrade the proteoglycan linkage region

Takagaki, K, Nakamura, T, Endo, M

Biochim Biophys Acta 1988
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
hydrolase activity, acting on glycosyl bonds of beta-xylosidase [lysosomal lumen]
Physical Entity
beta-xylosidase [lysosomal lumen]
Activity
hydrolase activity, acting on glycosyl bonds (0016798)
Authored
Jassal, B  (2011-10-21)
Reviewed
D'Eustachio, P  (2012-03-28)
Created
Jassal, B  (2011-10-21)