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Expression of XBP1(S)
Stable Identifier
R-HSA-1791121
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Unfolded Protein Response (UPR) (Homo sapiens)
ATF6 (ATF6-alpha) activates chaperones (Homo sapiens)
ATF6 (ATF6-alpha) activates chaperone genes (Homo sapiens)
Expression of XBP1(S) (Homo sapiens)
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The N-terminal fragment of ATF6-alpha contains a bZIP domain and binds the sequence CCACG in ER Stress Response Elements (ERSEs). ATF6-alpha binds ERSEs together with the heterotrimeric transcription factor NF-Y, which binds the sequence CCAAT in the ERSEs, and together the two factors activate transcription of ER stress-responsive genes. Evidence from overexpression and knockdowns indicates that ATF6-alpha is a potent activator but its homolog ATF6-beta is not and ATF6-beta may actually reduce expression of ER stress proteins. The XBP1 gene is transcribed to yield mRNA, the mRNA is spliced to yield Xbp(s) mRNA, and the mRNA is translated to yield protein.
Literature References
PubMed ID
Title
Journal
Year
10958673
ATF6 activated by proteolysis binds in the presence of NF-Y (CBF) directly to the cis-acting element responsible for the mammalian unfolded protein response
Mori, K
,
Yoshida, H
,
Yanagi, H
,
Negishi, M
,
Okada, T
,
Haze, K
,
Yura, T
Mol Cell Biol
2000
Participants
Input
XBP1 gene [nucleoplasm]
(Homo sapiens)
Output
XBP1-2 [nucleoplasm]
(Homo sapiens)
Participates
as an event of
ATF6 (ATF6-alpha) activates chaperone genes (Homo sapiens)
This event is regulated
Positively by
Regulator
ATF6(1-380) [nucleoplasm]
(Homo sapiens)
Regulator
NF-Y [nucleoplasm]
(Homo sapiens)
Authored
May, B (2011-10-13)
Reviewed
Gillespie, ME (2008-12-02)
D'Eustachio, P (2008-12-02)
Matthews, L (2008-12-02)
Urano, F (2010-04-30)
Created
May, B (2011-10-21)
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