GRB2:GAB1 binds to phosphorylated EGFR

Stable Identifier
R-HSA-177941
Type
Reaction
Species
Homo sapiens
Compartment
cytosol, plasma membrane, extracellular region
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GRB2:GAB1 binds to phosphorylated EGFR
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The regulatory subunit of PIK3 mediates the association of GAB1 and receptor protein-tyrosine kinases such as the EGF receptor, which can phosphorylate GAB1. It appears that the PIK3 regulatory subunit acts as an adaptor protein allowing GAB1 to serve as a substrate for several tyrosine kinases.

Literature References
PubMed ID Title Journal Year
9356464 Grb2-associated binder-1 mediates phosphatidylinositol 3-kinase activation and the promotion of cell survival by nerve growth factor

Emlet, DR, Holgado-Madruga, M, Wong, AJ, Dieterich, R, Moscatello, DK

Proc Natl Acad Sci U S A 1997
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Orthologous Events
GRB2:GAB1 binds to phosphorylated EGFR (Caenorhabditis elegans)
GRB2:GAB1 binds to phosphorylated EGFR (Canis familiaris)
GRB2:GAB1 binds to phosphorylated EGFR (Danio rerio)
GRB2:GAB1 binds to phosphorylated EGFR (Mus musculus)
GRB2:GAB1 binds to phosphorylated EGFR (Rattus norvegicus)
GRB2:GAB1 binds to phosphorylated EGFR (Sus scrofa)
Authored
Castagnoli, L  (2006-10-10)
Reviewed
Heldin, CH  (2008-02-12)
Created
Jassal, B  (2006-04-11)
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