Reactome | GRB2:GAB1 binds to phosphorylated EGFR

GRB2:GAB1 binds to phosphorylated EGFR

Stable Identifier

R-HSA-177941

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol, plasma membrane, extracellular region

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The regulatory subunit of PIK3 mediates the association of GAB1 and receptor protein-tyrosine kinases such as the EGF receptor, which can phosphorylate GAB1. It appears that the PIK3 regulatory subunit acts as an adaptor protein allowing GAB1 to serve as a substrate for several tyrosine kinases.

Literature References

PubMed ID	Title	Journal	Year
9356464	Grb2-associated binder-1 mediates phosphatidylinositol 3-kinase activation and the promotion of cell survival by nerve growth factor Holgado-Madruga, M, Moscatello, DK, Emlet, DR, Dieterich, R, Wong, AJ	Proc Natl Acad Sci U S A	1997