PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3)

Stable Identifier
R-HSA-177939
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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The kinase activity of PIK3 mediates the phosphorylation of PIP2 to form PIP3

Literature References
PubMed ID Title Journal Year
10648629 A novel positive feedback loop mediated by the docking protein Gab1 and phosphatidylinositol 3-kinase in epidermal growth factor receptor signaling

Rodrigues, GA, Falasca, M, Zhang, Z, Ong, SH, Schlessinger, J

Mol Cell Biol 2000
Participants
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
phosphatidylinositol-4,5-bisphosphate 3-kinase activity of EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:PI3K [plasma membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created