GAB1 phosphorylation by EGFR kinase

Stable Identifier
R-HSA-177930
Type
Reaction
Species
Homo sapiens
Compartment
cytosol, plasma membrane, extracellular region
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GAB1 phosphorylation by EGFR kinase
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EGFR kinase phosphorylates the phosphorylation sites tyrosine 627 and 659 on GAB1

Literature References
PubMed ID Title Journal Year
15231819 Ligand regulates epidermal growth factor receptor kinase specificity: activation increases preference for GAB1 and SHC versus autophosphorylation sites

Deb, TB, Wong, L, Johnson, GR, Fan, YX

J Biol Chem 2004
9890893 Identification of tyrosine phosphorylation sites in human Gab-1 protein by EGF receptor kinase in vitro

Bruning, JC, Knebel, B, Lehr, S, Siethoff, C, Herkner, A, Muller-Wieland, D, Krone, W, Klein, E, Kotzka, J, Meyer, HE, Klein, HW, Noelle, V

Biochemistry 1999
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Output
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as an event of
Catalyst Activity

protein tyrosine kinase activity of EGF-like ligands:p-6Y-EGFR:GRB2:GAB1 [plasma membrane]

Physical Entity
EGF-like ligands:p-6Y-EGFR:GRB2:GAB1 [plasma membrane] (Homo sapiens)
Activity
protein tyrosine kinase activity (GO:0004713)
Orthologous Events
GAB1 phosphorylation by EGFR kinase (Bos taurus)
GAB1 phosphorylation by EGFR kinase (Caenorhabditis elegans)
GAB1 phosphorylation by EGFR kinase (Canis familiaris)
GAB1 phosphorylation by EGFR kinase (Danio rerio)
GAB1 phosphorylation by EGFR kinase (Drosophila melanogaster)
GAB1 phosphorylation by EGFR kinase (Gallus gallus)
GAB1 phosphorylation by EGFR kinase (Mus musculus)
GAB1 phosphorylation by EGFR kinase (Rattus norvegicus)
GAB1 phosphorylation by EGFR kinase (Sus scrofa)
GAB1 phosphorylation by EGFR kinase (Xenopus tropicalis)
Authored
Castagnoli, L  (2006-10-10)
Reviewed
Heldin, CH  (2008-02-12)
Created
Jassal, B  (2006-04-11)
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