Reactome | Binding of GRB2 to GAB1

Binding of GRB2 to GAB1

Stable Identifier

R-HSA-177920

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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GRB2 (Growth factor receptor-bound protein 2) binds to GAB1 (GRB2-associated binding protein 1).

Literature References

PubMed ID	Title	Journal	Year
10913131	Identification of an atypical Grb2 carboxyl-terminal SH3 domain binding site in Gab docking proteins reveals Grb2-dependent and -independent recruitment of Gab1 to receptor tyrosine kinases Naujokas, MA, Lock, LS, Park, M, Royal, I	J Biol Chem	2000
12766170	Grb2-independent recruitment of Gab1 requires the C-terminal lobe and structural integrity of the Met receptor kinase domain Saucier, C, Lock, LS, Park, M, Frigault, MM	J Biol Chem	2003