Reactome | Binding of GRB2 to GAB1

Binding of GRB2 to GAB1

Stable Identifier

R-HSA-177920

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol

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GRB2 (Growth factor receptor-bound protein 2) binds to GAB1 (GRB2-associated binding protein 1).

Literature References

PubMed ID	Title	Journal	Year
12766170	Grb2-independent recruitment of Gab1 requires the C-terminal lobe and structural integrity of the Met receptor kinase domain Lock, LS, Frigault, MM, Saucier, C, Park, M	J Biol Chem	2003
10913131	Identification of an atypical Grb2 carboxyl-terminal SH3 domain binding site in Gab docking proteins reveals Grb2-dependent and -independent recruitment of Gab1 to receptor tyrosine kinases Lock, LS, Royal, I, Naujokas, MA, Park, M	J Biol Chem	2000

Participants

Input

Output

GRB2:GAB1 [cytosol] (Homo sapiens)

Participant Of

hasEvent

GAB1 signalosome

Orthologous Events

Binding of GRB2 to GAB1 (Bos taurus)

Binding of GRB2 to GAB1 (Caenorhabditis elegans)

Binding of GRB2 to GAB1 (Canis familiaris)

Binding of GRB2 to GAB1 (Danio rerio)

Binding of GRB2 to GAB1 (Drosophila melanogaster)

Binding of GRB2 to GAB1 (Gallus gallus)

Binding of GRB2 to GAB1 (Mus musculus)

Binding of GRB2 to GAB1 (Rattus norvegicus)

Binding of GRB2 to GAB1 (Sus scrofa)

Binding of GRB2 to GAB1 (Xenopus tropicalis)

Authored

Castagnoli, L (2006-10-10)

Reviewed

Heldin, CH (2008-02-12)

Created

Jassal, B (2006-04-11)