Viral dsRNA:TLR3:TICAM1 complex recruits TRAF6

Stable Identifier
R-HSA-177694
Type
Reaction [binding]
Species
Homo sapiens
Related Species
Rotavirus, Influenza A virus, Hepatitis B virus, Hepatitis C Virus, Human herpesvirus 1
Compartment
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TRAF6 is recruited to the N-terminal domain of TICAM1 and this event is followed by auto polyubiquitination and oligomerization of TRAF6.

Literature References
PubMed ID Title Journal Year
11057907 Activation of the IkappaB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chain

Deng, L, Wang, C, Spencer, E, Yang, L, Braun, A, You, J, Slaughter, C, Pickart, C, Chen, ZJ

Cell 2000
20047764 Direct binding of TRAF2 and TRAF6 to TICAM-1/TRIF adaptor participates in activation of the Toll-like receptor 3/4 pathway

Sasai, M, Tatematsu, M, Oshiumi, H, Funami, K, Matsumoto, M, Hatakeyama, S, Seya, T

Mol Immunol 2010
19112497 TRAF6 autoubiquitination-independent activation of the NFkappaB and MAPK pathways in response to IL-1 and RANKL

Walsh, MC, Kim, GK, Maurizio, PL, Molnar, EE, Choi, Y

PLoS One 2008
Participants
Participant Of
Orthologous Events
Authored
Reviewed
Created