Viral dsRNA:TLR3:TICAM1 complex recruits TRAF6

Stable Identifier
Reaction [binding]
Homo sapiens
Related Species
Influenza A virus, Rotavirus, Hepatitis B virus, Hepatitis C Virus, Human herpesvirus 1
Locations in the PathwayBrowser
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

TRAF6 is recruited to the N-terminal domain of TICAM1 and this event is followed by auto polyubiquitination and oligomerization of TRAF6.

Literature References
PubMed ID Title Journal Year
20047764 Direct binding of TRAF2 and TRAF6 to TICAM-1/TRIF adaptor participates in activation of the Toll-like receptor 3/4 pathway

Matsumoto, M, Hatakeyama, S, Oshiumi, H, Funami, K, Seya, T, Sasai, M, Tatematsu, M

Mol Immunol 2010
11057907 Activation of the IkappaB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chain

Deng, L, Pickart, C, Spencer, E, You, J, Wang, C, Slaughter, C, Braun, A, Chen, ZJ, Yang, L

Cell 2000
19112497 TRAF6 autoubiquitination-independent activation of the NFkappaB and MAPK pathways in response to IL-1 and RANKL

Walsh, MC, Molnar, EE, Maurizio, PL, Choi, Y, Kim, GK

PLoS One 2008
Orthologous Events
Cite Us!