Autointegration results in viral DNA circles

Stable Identifier
R-HSA-177539
Type
Pathway
Species
Homo sapiens
Related Species
Human immunodeficiency virus 1
Compartment
nucleoplasm
ReviewStatus
5/5
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Autointegration results in viral DNA circles
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In this pathway, the viral integration machinery uses a site within the viral DNA as an integration target. This results in a covalent rearrangment of the viral DNA. The resulting DNA forms are not substrates for integration.
It has been suggested that the cellular BAF protein binds to viral DNA and diminishes autointegration by coating and condensing the viral DNA, thereby making it a less efficient integration target.
Literature References
PubMed ID Title Journal Year
9465049 A previously unidentified host protein protects retroviral DNA from autointegration

Lee, MS, Craigie, R

Proc Natl Acad Sci U S A 1998
7937898 Protection of retroviral DNA from autointegration: involvement of a cellular factor

Lee, MS, Craigie, R

Proc Natl Acad Sci U S A 1994
Participants
Events
Participates
as an event of
Disease
Name Identifier Synonyms
Human immunodeficiency virus infectious disease DOID:526 HIV infection
Authored
D'Eustachio, P  (2006-05-19)
Gopinathrao, G  (2006-05-19)
Reviewed
Bushman, FD  (2006-10-31)
Created
Gopinathrao, G  (2006-04-02)
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