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DNM1 [plasma membrane]
Stable Identifier
R-HSA-177488
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Dynamin-1
Locations in the PathwayBrowser
Expand all
Developmental Biology (Homo sapiens)
Nervous system development (Homo sapiens)
Axon guidance (Homo sapiens)
EPH-Ephrin signaling (Homo sapiens)
EPH-ephrin mediated repulsion of cells (Homo sapiens)
Clathrin internalises EPH:EFN complexes (Homo sapiens)
DNM1 [plasma membrane] (Homo sapiens)
EPHB:EFNB:F-actin:AP-2:Clathrrin:Dynamin [plasma membrane] (Homo sapiens)
DNM1 [plasma membrane] (Homo sapiens)
L1CAM interactions (Homo sapiens)
Recycling pathway of L1 (Homo sapiens)
Formation of clathrin coated vesicle (Homo sapiens)
Dynamin-1/2/3 [plasma membrane] (Homo sapiens)
DNM1 [plasma membrane] (Homo sapiens)
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
MHC class II antigen presentation (Homo sapiens)
Internalization of MHC II:Ii clathrin coated vesicle (Homo sapiens)
Dynamin-1/2/3 [plasma membrane] (Homo sapiens)
DNM1 [plasma membrane] (Homo sapiens)
Innate Immune System (Homo sapiens)
Toll-like Receptor Cascades (Homo sapiens)
Toll Like Receptor 4 (TLR4) Cascade (Homo sapiens)
Endocytosis of TLR4:LY96:LPS:CD14 (Homo sapiens)
Dynamin-1/2/3 [plasma membrane] (Homo sapiens)
DNM1 [plasma membrane] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by NTRKs (Homo sapiens)
Signaling by NTRK1 (TRKA) (Homo sapiens)
Retrograde neurotrophin signalling (Homo sapiens)
Endocytosis (internalization) of clathrin-coated vesicle (Homo sapiens)
Dynamin-1/2/3 [plasma membrane] (Homo sapiens)
DNM1 [plasma membrane] (Homo sapiens)
Vesicle-mediated transport (Homo sapiens)
Membrane Trafficking (Homo sapiens)
Gap junction trafficking and regulation (Homo sapiens)
Gap junction trafficking (Homo sapiens)
Gap junction degradation (Homo sapiens)
Formation of annular gap junctions (Homo sapiens)
Dynamin is recruited to the gap junction plaque (Homo sapiens)
Dynamin [plasma membrane] (Homo sapiens)
DNM1 [plasma membrane] (Homo sapiens)
Planar gap junction plaques associated with Dab2 and Dynamin [plasma membrane] (Homo sapiens)
Dynamin [plasma membrane] (Homo sapiens)
DNM1 [plasma membrane] (Homo sapiens)
Internalization of gap junction plaques (Homo sapiens)
Planar gap junction plaques associated with Dab2 and Dynamin [plasma membrane] (Homo sapiens)
Dynamin [plasma membrane] (Homo sapiens)
DNM1 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q05193 DNM1
Gene Names
DNM1, DNM
Chain
chain:1-864
Reference Genes
BioGPS Gene:1759 DNM1
COSMIC (genes):DNM1 DNM1
CTD Gene:1759 DNM1
dbSNP Gene:1759 DNM1
ENSEMBL:ENSG00000106976 DNM1
HGNC:2972 DNM1
KEGG Gene (Homo sapiens):1759 DNM1
Monarch:1759 DNM1
NCBI Gene:1759 DNM1
OMIM:602377 DNM1
UCSC:Q05193 DNM1
Reference Transcript
RefSeq:NM_001005336.2 DNM1
RefSeq:NM_001288737.1 DNM1
RefSeq:NM_001288739.1 DNM1
RefSeq:XM_005251769.2 DNM1
RefSeq:NM_001288738.1 DNM1
RefSeq:XM_005251768.2 DNM1
RefSeq:NM_004408.3 DNM1
RefSeq:XM_017014371.1 DNM1
Other Identifiers
0001980086
11720616_a_at
11754476_x_at
11761584_x_at
17089549
1759
215116_s_at
3190243
3190244
3190247
3190249
3190250
3190251
3190252
3190253
3190254
3190255
3190256
3190260
3190262
3190272
3190273
3190274
3190276
3190279
3190281
3190282
3190283
3190284
3190286
3190287
3190292
3190293
3190294
3190295
3190296
3190297
3190298
3190302
3190304
32138_at
3603087
3605040
8158183
A_23_P135273
A_33_P3329419
GE57587
GE83830
GO:0000166
GO:0000266
GO:0001917
GO:0002031
GO:0003374
GO:0003674
GO:0003723
GO:0003924
GO:0005515
GO:0005525
GO:0005575
GO:0005576
GO:0005615
GO:0005622
GO:0005634
GO:0005654
GO:0005737
GO:0005739
GO:0005794
GO:0005856
GO:0005874
GO:0005886
GO:0006810
GO:0006897
GO:0006898
GO:0007005
GO:0007032
GO:0007165
GO:0007267
GO:0008017
GO:0008021
GO:0008022
GO:0008092
GO:0008150
GO:0014069
GO:0015031
GO:0015630
GO:0016020
GO:0016185
GO:0016192
GO:0016787
GO:0017124
GO:0019899
GO:0019901
GO:0022607
GO:0030117
GO:0030424
GO:0031410
GO:0031623
GO:0031749
GO:0031966
GO:0032991
GO:0042802
GO:0043167
GO:0043196
GO:0043197
GO:0043226
GO:0044327
GO:0044877
GO:0045202
GO:0045211
GO:0048013
GO:0048285
GO:0050803
GO:0050804
GO:0050998
GO:0061024
GO:0061025
GO:0065003
GO:0070062
GO:0098684
GO:0098835
GO:0098844
GO:0098884
GO:0098978
GO:1900242
GO:1900244
GO:1901998
GO:1903423
GO:1904645
Hs.166161.2.S1_3p_a_at
ILMN_1805200
L07807_s_at
TC09000679.hg
TC09000680.hg
TC15000502.hg
Participant Of
hasCandidate
Dynamin [plasma membrane]
Dynamin-1/2/3 [plasma membrane]
hasComponent
EPHB:EFNB:F-actin:AP-2:Clathrrin:Dynamin [plasma membrane]
input
Clathrin internalises EPH:EFN complexes
Other forms of this molecule
DNM1 [lysosomal membrane]
DNM1 [cytosol]
Inferred To
Homologues of DNM1 [plasma membrane] (Dictyostelium discoideum)
Homologues of DNM1 [plasma membrane] (Schizosaccharomyces pombe)
dlpA [plasma membrane] (Dictyostelium discoideum)
Dnm1 [plasma membrane] (Mus musculus)
Dnm1 [plasma membrane] (Rattus norvegicus)
dyn-1 [plasma membrane] (Caenorhabditis elegans)
DNM1 [plasma membrane] (Canis familiaris)
DNM1 [plasma membrane] (Gallus gallus)
DNM1 [plasma membrane] (Sus scrofa)
trio [plasma membrane] (Xenopus tropicalis)
msp1 [plasma membrane] (Schizosaccharomyces pombe)
dlpB [plasma membrane] (Dictyostelium discoideum)
vps1 [plasma membrane] (Schizosaccharomyces pombe)
dymA [plasma membrane] (Dictyostelium discoideum)
dnm1a [plasma membrane] (Danio rerio)
dymB [plasma membrane] (Dictyostelium discoideum)
shi [plasma membrane] (Drosophila melanogaster)
dnm1 [plasma membrane] (Schizosaccharomyces pombe)
Cross References
RefSeq
NP_001275668.1
,
NP_004399.2
,
XP_005251826.1
,
XP_005251825.1
,
NP_001275666.1
,
NP_001275667.1
,
XP_016869860.1
,
NP_001005336.1
ZINC - World Drugs
DYN1_HUMAN
OpenTargets
ENSG00000106976
ZINC - Substances
DYN1_HUMAN
ZINC target
Q05193
PRO
Q05193
PDB
6DLV
,
4UUK
,
3ZYC
,
2X2E
,
3SNH
,
1DYN
,
5D3Q
,
2DYN
,
2X2F
,
4UUD
,
6DLU
,
3ZYS
GeneCards
Q05193
HPA
ENSG00000106976-DNM1
Ensembl
ENST00000372923
,
ENSP00000345680
,
ENST00000393594
,
ENSP00000419225
,
ENST00000475805
,
ENSP00000420045
,
ENSP00000487310
,
ENSP00000377219
,
ENSG00000106976
,
ENSP00000362014
,
ENST00000486160
,
ENST00000627543
,
ENST00000341179
ZINC - Predictions - Purchasable
DYN1_HUMAN
Orphanet
23223
HMDB Protein
HMDBP08363
Interactors (15)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q05193 DNM1
3
DNM1 [cytosol]
(R-HSA-2213182)
DNM1 [lysosomal membrane]
(R-HSA-196150)
DNM1 [plasma membrane]
(R-HSA-177488)
0.931
13
UniProt:P62993 GRB2
1
GRB2 [cytosol]
(R-HSA-8983328)
0.829
7
UniProt:Q9Y5X1 SNX9
3
SNX9 [Golgi membrane]
(R-HSA-432988)
SNX9 [cytosol]
(R-HSA-8867737)
SNX9 [cytoplasmic vesicle membrane]
(R-HSA-432990)
0.775
5
UniProt:P49418 AMPH
1
AMPH [cytosol]
(R-HSA-8867728)
0.766
6
UniProt:Q15811 ITSN1
1
ITSN1 [cytosol]
(R-HSA-3006481)
0.623
3
GTP [ChEBI:15996]
13
GTP [early endosome membrane]
(R-ALL-2130170)
GTP [cilium]
(R-ALL-5617813)
GTP [lysosomal membrane]
(R-ALL-2213216)
GTP [platelet dense granule lumen]
(R-ALL-114625)
GTP [cytoplasmic vesicle membrane]
(R-ALL-1996291)
GTP [ER to Golgi transport vesicle membrane]
(R-ALL-983318)
GTP [extracellular region]
(R-ALL-114626)
GTP [Golgi lumen]
(R-ALL-8851242)
GTP [endocytic vesicle lumen]
(R-ALL-8851508)
GTP [Golgi membrane]
(R-ALL-1806221)
GTP [mitochondrial matrix]
(R-ALL-113573)
GTP [nucleoplasm]
(R-ALL-113571)
GTP [cytosol]
(R-ALL-29438)
0.609
2
UniProt:Q96RU3 FNBP1
1
FNBP1 [cytosol]
(R-HSA-8862261)
0.576
5
ChEBI:51987 GDP-TETRAFLUOROALUMINATE
0.558
2
UniProt:P19804
5
Nme2 [extracellular region]
(R-RNO-6806464)
Nme2 [ficolin-1-rich granule lumen]
(R-RNO-6803324)
Nme2 [secretory granule lumen]
(R-RNO-6803277)
Nme2 [cytosol]
(R-RNO-6806876)
Nme2 [cytosol]
(R-RNO-60024)
0.544
2
UniProt:Q5S007 LRRK2
1
LRRK2 [cytosol]
(R-HSA-5661173)
0.543
4
UniProt:Q8IVI9 NOSTRIN
2
NOSTRIN [plasma membrane]
(R-HSA-202134)
NOSTRIN [endocytic vesicle membrane]
(R-HSA-535014)
0.524
3
UniProt:Q8WV41 SNX33
0.524
2
UniProt:P16333 NCK1
2
NCK1 [cytosol]
(R-HSA-197954)
NCK1 [plasma membrane]
(R-HSA-202992)
0.524
2
UniProt:Q96JI7 SPTCS
0.508
2
UniProt:Q9QYW3 PHOCN
0.489
2
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