Reactome | DNM1 [plasma membrane]

DNM1 [plasma membrane]

Stable Identifier

R-HSA-177488

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Dynamin-1

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q05193 DNM1

Gene Names

DNM1, DNM

Chain

chain:1-864

Reference Genes

BioGPS Gene:1759 DNM1

COSMIC (genes):DNM1 DNM1

CTD Gene:1759 DNM1

dbSNP Gene:1759 DNM1

ENSEMBL:ENSG00000106976.21 DNM1

HGNC:2972 DNM1

KEGG Gene (Homo sapiens):1759 DNM1

Monarch:1759 DNM1

NCBI Gene:1759 DNM1

OMIM:602377 DNM1

UCSC:Q05193 DNM1

Reference Transcript

Other Identifiers

0001980086

11720616_a_at

11754476_x_at

11761584_x_at

17089549

1759

215116_PM_s_at

215116_s_at

3190243

3190244

3190247

3190249

3190250

3190251

3190252

3190253

3190254

3190255

3190256

3190260

3190262

3190272

3190273

3190274

3190276

3190279

3190281

3190282

3190283

3190284

3190286

3190287

3190292

3190293

3190294

3190295

3190296

3190297

3190298

3190302

3190304

32138_at

3603087

3605040

8158183

A_23_P135273

A_33_P3329419

GE57587

GE83830

GO:0000166

GO:0001917

GO:0003674

GO:0003723

GO:0003924

GO:0005515

GO:0005525

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005737

GO:0005856

GO:0005874

GO:0005886

GO:0006897

GO:0006898

GO:0007032

GO:0008017

GO:0008092

GO:0008150

GO:0016020

GO:0016185

GO:0016192

GO:0016787

GO:0019899

GO:0019901

GO:0023052

GO:0030117

GO:0031623

GO:0032991

GO:0042802

GO:0043167

GO:0043226

GO:0045202

GO:0048488

GO:0050804

GO:0061024

GO:0070062

GO:0098684

GO:0098835

GO:0098978

GO:1901998

HMNXSV003035649

HMNXSV003055054

Hs.166161.2.S1_3p_a_at

ILMN_1805200

L07807_s_at

TC09000679.hg

TC09000680.hg

TC15000502.hg

Participates

as a component of

EPHB:EFNB:F-actin:AP-2:Clathrrin:Dynamin [plasma membrane] (Homo sapiens)

as an input of

Clathrin internalises EPH:EFN complexes (Homo sapiens)

as a candidate of

Other forms of this molecule

DNM1 [cytosol]

DNM1 [lysosomal membrane]

Inferred To

DNM1 [plasma membrane] (Bos taurus)

DNM1 [plasma membrane] (Caenorhabditis elegans)

DNM1 [plasma membrane] (Canis familiaris)

DNM1 [plasma membrane] (Danio rerio)

DNM1 [plasma membrane] (Drosophila melanogaster)

DNM1 [plasma membrane] (Gallus gallus)

DNM1 [plasma membrane] (Mus musculus)

DNM1 [plasma membrane] (Rattus norvegicus)

DNM1 [plasma membrane] (Sus scrofa)

dnm1 [plasma membrane] (Xenopus tropicalis)

Cross References

RefSeq

NP_001275667.1, NP_001005336.1, XP_016869860.1, NP_001275668.1, NP_001275666.1, XP_005251825.1, NP_004399.2, XP_005251826.1

ZINC - World Drugs

DYN1_HUMAN

OpenTargets

ENSG00000106976

ZINC - Substances

DYN1_HUMAN

ZINC target

Q05193

PRO

Q05193

PDB

3ZYC, 4UUD, 6S9A, 6DLV, 4UUK, 2X2F, 5D3Q, 2DYN, 3ZYS, 2X2E, 6DLU, 7AX3, 1DYN, 3SNH

GeneCards

Q05193

HPA

ENSG00000106976-DNM1

Ensembl

ENSP00000487310, ENSP00000362014, ENST00000627543, ENST00000372923, ENST00000475805, ENSP00000345680, ENSP00000377219, ENSP00000420045, ENST00000486160, ENST00000393594, ENSP00000419225, ENST00000341179, ENSG00000106976

Pharos - Targets

Q05193

ZINC - Predictions - Purchasable

DYN1_HUMAN

Orphanet

23223

HMDB Protein

HMDBP08363

Interactors (15)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q05193 DNM1	3	DNM1 [cytosol] (R-HSA-2213182) DNM1 [lysosomal membrane] (R-HSA-196150) DNM1 [plasma membrane] (R-HSA-177488)	0.931	13
UniProt:P62993 GRB2	1	GRB2 [cytosol] (R-HSA-8983328)	0.829	7
UniProt:Q9Y5X1 SNX9	3	SNX9 [cytosol] (R-HSA-8867737) SNX9 [Golgi membrane] (R-HSA-432988) SNX9 [cytoplasmic vesicle membrane] (R-HSA-432990)	0.775	5
UniProt:P49418 AMPH	1	AMPH [cytosol] (R-HSA-8867728)	0.766	6
UniProt:Q15811 ITSN1	1	ITSN1 [cytosol] (R-HSA-3006481)	0.623	3
GTP [ChEBI:15996]	7	GTP [cilium] (R-ALL-5617813) GTP [early endosome membrane] (R-ALL-2130170) GTP [lysosomal membrane] (R-ALL-2213216) GTP [platelet dense granule lumen] (R-ALL-114625) GTP [cytoplasmic vesicle membrane] (R-ALL-1996291) GTP [ER to Golgi transport vesicle membrane] (R-ALL-983318) GTP [Golgi membrane] (R-ALL-1806221)	0.609	2
UniProt:Q96RU3 FNBP1	1	FNBP1 [cytosol] (R-HSA-8862261)	0.576	5
ChEBI:51987 GDP-TETRAFLUOROALUMINATE			0.558	2
UniProt:P19804	5	NME2P1 [cytosol] (R-RNO-6806876) NME2 [cytosol] (R-RNO-60024) NME2 [secretory granule lumen] (R-RNO-6803277) NME2 [extracellular region] (R-RNO-6806464) NME2 [ficolin-1-rich granule lumen] (R-RNO-6803324)	0.544	2
UniProt:Q5S007 LRRK2	1	LRRK2 [cytosol] (R-HSA-5661173)	0.543	4
UniProt:Q8IVI9 NOSTRIN	2	NOSTRIN [endocytic vesicle membrane] (R-HSA-535014) NOSTRIN [plasma membrane] (R-HSA-202134)	0.524	3
UniProt:Q8WV41 SNX33			0.524	2
UniProt:P16333 NCK1	2	NCK1 [plasma membrane] (R-HSA-202992) NCK1 [cytosol] (R-HSA-197954)	0.524	2
UniProt:Q96JI7 SPTCS			0.508	2
UniProt:Q9QYW3 PHOCN			0.489	2