Axonal transport of NGF:Trk complexes

Stable Identifier
R-HSA-177479
Type
Reaction
Species
Homo sapiens
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Of the internalized NGF:TRK complexes, many undergo recycling and/or proteolysis. Only a small fraction is retrogradely transported. Vesicles containing neurotrophin, activated receptors and downstream kinases are transported through axons by the action of dynein, which produces a force towards the end of microtubules.

Literature References
PubMed ID Title Journal Year
11157096 Association of Trk neurotrophin receptors with components of the cytoplasmic dynein motor

Kong, H, Perez, P, Arevalo, JC, Sung, C, Chuang, J, Yano, H, Lee, FS, Chao, MV

J Neurosci 2001
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Catalyst Activity

microtubule motor activity of DNAL4 [plasma membrane]

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