Axonal transport of NGF:Trk complexes

Stable Identifier
R-HSA-177479
Type
Reaction [transition]
Species
Homo sapiens
Compartment
extracellular region, plasma membrane
ReviewStatus
5/5
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Axonal transport of NGF:Trk complexes
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Of the internalized NGF:TRK complexes, many undergo recycling and/or proteolysis. Only a small fraction is retrogradely transported. Vesicles containing neurotrophin, activated receptors and downstream kinases are transported through axons by the action of dynein, which produces a force towards the end of microtubules.

Literature References
PubMed ID Title Journal Year
11157096 Association of Trk neurotrophin receptors with components of the cytoplasmic dynein motor

Kong, H, Perez, P, Arevalo, JC, Sung, C, Chuang, J, Yano, H, Lee, FS, Chao, MV

J Neurosci 2001
Participants
Input
Output
Participates
as an event of
Event Information
Go Biological Process
microtubule-based movement (0007018)
Catalyst Activity

microtubule motor activity of DNAL4 [plasma membrane]

Physical Entity
DNAL4 [plasma membrane] (Homo sapiens)
Activity
microtubule motor activity (GO:0003777)
Orthologous Events
Axonal transport of NGF:Trk complexes (Bos taurus)
Axonal transport of NGF:Trk complexes (Canis familiaris)
Axonal transport of NGF:Trk complexes (Danio rerio)
Axonal transport of NGF:Trk complexes (Drosophila melanogaster)
Axonal transport of NGF:Trk complexes (Gallus gallus)
Axonal transport of NGF:Trk complexes (Mus musculus)
Axonal transport of NGF:Trk complexes (Rattus norvegicus)
Axonal transport of NGF:Trk complexes (Sus scrofa)
Authored
Nasi, S  (2006-10-10)
Annibali, D  (2006-10-10)
Reviewed
Greene, LA  (2007-11-08)
Created
Jassal, B  (2006-03-31)
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