Axonal transport of NGF:Trk complexes

Stable Identifier
R-HSA-177479
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Of the internalized NGF:TRK complexes, many undergo recycling and/or proteolysis. Only a small fraction is retrogradely transported. Vesicles containing neurotrophin, activated receptors and downstream kinases are transported through axons by the action of dynein, which produces a force towards the end of microtubules.

Literature References
PubMed ID Title Journal Year
11157096 Association of Trk neurotrophin receptors with components of the cytoplasmic dynein motor

Yano, H, Lee, FS, Kong, H, Chuang, J, Arevalo, JC, Perez, P, Sung, C, Chao, MV

J Neurosci 2001
Participants
Participant Of
Event Information
Go Biological Process
Catalyst Activity
Catalyst Activity
Title
microtubule motor activity of DNAL4 [plasma membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created