Reactome | PKA phosphorylates PDE4B

PKA phosphorylates PDE4B

Stable Identifier

R-HSA-177284

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR downstream signalling (Homo sapiens)
    - G alpha (i) signalling events (Homo sapiens)
      - Opioid Signalling (Homo sapiens)
        
        DARPP-32 events (Homo sapiens)
        
        PKA phosphorylates PDE4B (Homo sapiens)

General

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The phosphorylation of the phosphodiesterase increases its activity, forming a negative feedback loop of the cAMP signal.

Literature References

PubMed ID	Title	Journal	Year
8663227	Phosphorylation and activation of a cAMP-specific phosphodiesterase by the cAMP-dependent protein kinase. Involvement of serine 54 in the enzyme activation. Sette, C, Conti, M	J Biol Chem	1996
9099992	Protein kinase A-dependent activation of PDE4 (cAMP-specific cyclic nucleotide phosphodiesterase) in cultured bovine vascular smooth muscle cells Ekholm, D, Belfrage, P, Manganiello, V, Degerman, E	Biochim Biophys Acta	1997