PKA phosphorylates DARPP-32 on Thr34

Stable Identifier
R-HSA-177275
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
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PKA phosphorylates DARPP-32 on Thr34
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DARPP-32 is phosphorylated by cAMP-dependent protein kinase (PKA) on a single threonine residue, Thr34, resulting in its conversion into a potent inhibitor of protein phosphatase-1.

Literature References
PubMed ID Title Journal Year
6501302 DARPP-32, a dopamine- and adenosine 3':5'-monophosphate-regulated neuronal phosphoprotein. I. Amino acid sequence around the phosphorylated threonine

Hemmings HC, Jr, Williams, KR, Konigsberg, WH, Greengard, P

J Biol Chem 1984
6296685 A dopamine- and cyclic AMP-regulated phosphoprotein enriched in dopamine-innervated brain regions.

Aswad, DW, Walaas, SI, Greengard, P

Nature 1983
Participants
Input
Output
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as an event of
Catalyst Activity

cAMP-dependent protein kinase activity of PKA catalytic subunit [cytosol]

Physical Entity
PKA catalytic subunit [cytosol] (Homo sapiens)
Activity
cAMP-dependent protein kinase activity (GO:0004691)
Orthologous Events
PKA phosphorylates DARPP-32 on Thr34 (Bos taurus)
PKA phosphorylates DARPP-32 on Thr34 (Canis familiaris)
PKA phosphorylates DARPP-32 on Thr34 (Danio rerio)
PKA phosphorylates DARPP-32 on Thr34 (Gallus gallus)
PKA phosphorylates DARPP-32 on Thr34 (Mus musculus)
PKA phosphorylates DARPP-32 on Thr34 (Rattus norvegicus)
PKA phosphorylates DARPP-32 on Thr34 (Sus scrofa)
Authored
Jassal, B  (2004-03-31)
Le Novere, N  (2004-03-31)
Reviewed
Castagnoli, L  (2008-11-06)
Created
Jassal, B  (2006-03-27)
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