phenylacetyl-CoA + glutamine => phenylacetyl glutamine + Coenzyme A

Stable Identifier
R-HSA-177160
Type
Reaction [transition]
Species
Homo sapiens
Compartment
mitochondrial matrix
Synonyms
Synthesis of phenylacetyl glutamine from phenylacetyl-CoA and glutamine
ReviewStatus
5/5
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phenylacetyl-CoA + glutamine => phenylacetyl glutamine + Coenzyme A
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Phenylacetyl CoA and glutamine react to form phenylacetyl glutamine and Coenzyme A. The enzyme that catalyzes this reaction has been purified from human liver mitochondria and shown to be a distinct polypeptide species from glycine-N-acyltransferase (Webster et al. 1976). This human glutamine-N-acyltransferase activity has not been characterized by sequence analysis at the protein or DNA level, however, and thus cannot be associated with a known human protein in the annotation of phenylacetate conjugation.

Literature References
PubMed ID Title Journal Year
931988 Identification of separate acyl- CoA:glycine and acyl-CoA:L-glutamine N-acyltransferase activities in mitochondrial fractions from liver of rhesus monkey and man

Strong, JM, Mieyal, JJ, Lucas, SV, Webster, LT, Siddiqui, UA

J Biol Chem 1976
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Catalyst Activity

N-acyltransferase activity of glutamine-N-acyltransferase [mitochondrial matrix]

Physical Entity
glutamine-N-acyltransferase [mitochondrial matrix] (Homo sapiens)
Activity
N-acyltransferase activity (GO:0016410)
Cross References
Rhea
Reviewed
D'Eustachio, P  (2008-05-28)
Created
D'Eustachio, P  (2006-03-24)
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