Reactome | phenylacetate + Coenzyme A + ATP => phenylacetyl-CoA + AMP + pyrophosphate

phenylacetate + Coenzyme A + ATP => phenylacetyl-CoA + AMP + pyrophosphate

Stable Identifier

R-HSA-177157

Type

Reaction [transition]

Species

Homo sapiens

Compartment

mitochondrial matrix

Synonyms

Synthesis of phenylacetyl CoA from phenylacetate and Coenzyme A

ReviewStatus

5/5

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phenylacetate + Coenzyme A + ATP => phenylacetyl-CoA + AMP + pyrophosphate

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Phenylacetate and ATP react with coenzyme A to form phenylacetyl CoA, AMP, and pyrophosphate (Vessey et al. 1999). Two human CoA ligases have been characterized that catalyze this reaction efficiently in vitro: acyl-CoA synthetase medium-chain family member 1 (BUCS1) (Fujino et al. 2001) and xenobiotic/medium-chain fatty acid:CoA ligase (Vessey et al. 2003). Their relative contributions to phenylacetate metabolism in vivo are unknown.

Literature References

PubMed ID	Title	Journal	Year
11470804	Molecular identification and characterization of two medium-chain acyl-CoA synthetases, MACS1 and the Sa gene product Fujino, T, Takei, YA, Sone, H, Ioka, RX, Kamataki, A, Magoori, K, Takahashi, S, Sakai, J, Yamamoto, TT	J Biol Chem	2001
12616642	Isolation, sequencing, and expression of a cDNA for the HXM-A form of xenobiotic/medium-chain fatty acid:CoA ligase from human liver mitochondria Vessey, DA, Lau, E, Kelley, M, Warren, RS	J Biochem Mol Toxicol	2003
10434065	Characterization of the CoA ligases of human liver mitochondria catalyzing the activation of short- and medium-chain fatty acids and xenobiotic carboxylic acids Vessey, DA, Kelley, M, Warren, RS	Biochim Biophys Acta	1999