phenylacetate + Coenzyme A + ATP => phenylacetyl-CoA + AMP + pyrophosphate

Stable Identifier
Reaction [transition]
Homo sapiens
Synthesis of phenylacetyl CoA from phenylacetate and Coenzyme A
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Phenylacetate and ATP react with coenzyme A to form phenylacetyl CoA, AMP, and pyrophosphate (Vessey et al. 1999). Two human CoA ligases have been characterized that catalyze this reaction efficiently in vitro: acyl-CoA synthetase medium-chain family member 1 (BUCS1) (Fujino et al. 2001) and xenobiotic/medium-chain fatty acid:CoA ligase (Vessey et al. 2003). Their relative contributions to phenylacetate metabolism in vivo are unknown.

Literature References
PubMed ID Title Journal Year
11470804 Molecular identification and characterization of two medium-chain acyl-CoA synthetases, MACS1 and the Sa gene product

Sakai, J, Takei, YA, Kamataki, A, Takahashi, S, Fujino, T, Sone, H, Yamamoto, TT, Magoori, K, Ioka, RX

J Biol Chem 2001
12616642 Isolation, sequencing, and expression of a cDNA for the HXM-A form of xenobiotic/medium-chain fatty acid:CoA ligase from human liver mitochondria

Kelley, M, Warren, RS, Lau, E, Vessey, DA

J Biochem Mol Toxicol 2003
10434065 Characterization of the CoA ligases of human liver mitochondria catalyzing the activation of short- and medium-chain fatty acids and xenobiotic carboxylic acids

Kelley, M, Warren, RS, Vessey, DA

Biochim Biophys Acta 1999
Catalyst Activity

CoA-ligase activity of xenobiotic/medium-chain fatty acid:CoA ligases [mitochondrial matrix]

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