Reactome | GINS4 [nucleoplasm]

GINS4 [nucleoplasm]

Stable Identifier

R-HSA-176963

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

SLD5P

Locations in the PathwayBrowser for interactor UniProt:Q96KQ4 PPP1R13B

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External Reference Information

External Reference

UniProt:Q9BRT9 GINS4

Gene Names

GINS4, SLD5

Chain

chain:1-223, initiator methionine:, chain:2-223

Reference Genes

BioGPS Gene:84296 GINS4

COSMIC (genes):GINS4 GINS4

CTD Gene:84296 GINS4

dbSNP Gene:84296 GINS4

ENSEMBL:ENSG00000147536 GINS4

ENSEMBL_homo_sapiens_GENE:ENSG00000147536.12 GINS4

HGNC:28226 GINS4

KEGG Gene (Homo sapiens):84296 GINS4

Monarch:84296 GINS4

NCBI Gene:84296 GINS4

OMIM:610611 GINS4

UCSC:Q9BRT9 GINS4

Reference Transcript

Other Identifiers

11736596_s_at

11736597_x_at

11751810_x_at

11762582_at

1554356_3p_at

1554356_PM_at

1554356_at

17068385

211767_3p_at

211767_PM_at

211767_at

235029_PM_at

235029_at

3095765

3095767

3095768

3095769

3095783

3095785

3095786

3095787

3095788

3095793

3095795

3095796

3095797

3095798

3095799

73514_at

8146130

84296

87976_at

A_14_P107136

A_23_P136787

A_24_P922497

A_33_P3340040

GE83384

GO:0000228

GO:0000727

GO:0000811

GO:0001833

GO:0005515

GO:0005634

GO:0005654

GO:0005694

GO:0005737

GO:0006260

GO:0006261

GO:0006268

GO:0006281

GO:0006310

GO:0043226

GO:0048856

GO:0071162

HMNXSV003010290

Hs.293545.0.A1_3p_at

Hs2.380217.1.S1_3p_x_at

PH_hs_0016308

TC08000318.hg

TC08001894.hg

g13543688_3p_at

g13543688_3p_x_at

Participates

as a component of

GINS complex [nucleoplasm] (Homo sapiens)

as an input of

Formation of GINS complex (Homo sapiens)

Inferred To

sld-5 [nucleoplasm] (Caenorhabditis elegans)

Gins4 [nucleoplasm] (Mus musculus)

Gins4 [nucleoplasm] (Rattus norvegicus)

sld5 [nucleoplasm] (Schizosaccharomyces pombe)

SLD5 [nucleoplasm] (Saccharomyces cerevisiae)

GINS4 [nucleoplasm] (Bos taurus)

GINS4 [nucleoplasm] (Canis familiaris)

GINS4 [nucleoplasm] (Sus scrofa)

Sld5 [nucleoplasm] (Drosophila melanogaster)

gins4 [nucleoplasm] (Dictyostelium discoideum)

Cross References

RefSeq

XP_005273716.1, NP_115712.1

OpenTargets

ENSG00000147536

GeneCards

Q9BRT9

HPA

ENSG00000147536-GINS4

Ensembl

ENST00000520710, ENSP00000276533, ENSG00000147536, ENST00000518671, ENSP00000429581, ENSP00000428754, ENST00000276533

PRO

Q9BRT9

Pharos - Targets

Q9BRT9

PDB

2Q9Q, 2E9X, 2EHO, 6XTX, 8B9D, 6XTY, 7PLO, 7PFO, 8OK2

Interactors (18)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9Y248 GINS2	1	GINS2 [nucleoplasm] (R-HSA-176975)	0.871	12
UniProt:Q14691 GINS1	1	GINS1 [nucleoplasm] (R-HSA-176955)	0.813	8
UniProt:P57059 SIK1	1	SIK1 [nucleoplasm] (R-HSA-5656504)	0.643	4
UniProt:Q9BTE3 MCMBP			0.589	2
UniProt:O75419 CDC45	1	CDC45 [nucleoplasm] (R-HSA-68563)	0.574	3
UniProt:A0A0B4J2F2 SIK1B			0.556	3
UniProt:Q9NPF5 DMAP1	1	DMAP1 [nucleoplasm] (R-HSA-212166)	0.556	3
UniProt:Q9BYU1 PBX4			0.556	3
UniProt:Q96KQ4 PPP1R13B	1	PPP1R13B [nucleoplasm] (R-HSA-6799775)	0.556	3
UniProt:Q68G74 LHX8			0.556	3
UniProt:Q9NSA3 CTNNBIP1	1	CTNNBIP1 [nucleoplasm] (R-HSA-3772388)	0.556	3
UniProt:Q96L93-6 KIF16B			0.556	3
UniProt:Q9NQY0 BIN3			0.556	3
UniProt:Q9BRX5 GINS3	1	GINS3 [nucleoplasm] (R-HSA-5688046)	0.527	3
UniProt:Q9BVW5 TIPIN	1	TIPIN [nucleoplasm] (R-HSA-5684983)	0.527	2
UniProt:P16104 H2AFX	7	Me2sR4-H2AFX [nucleoplasm] (R-HSA-5218317) H2AFX [nucleoplasm] (R-HSA-56151) p-Y143-H2AFX [nucleoplasm] (R-HSA-5683942) p-S140,Y143-H2AFX [nucleoplasm] (R-HSA-5683953) p-S140-H2AFX [nucleoplasm] (R-HSA-75170) K63PolyUb-K14,K16,p-S140-H2AFX [nucleoplasm] (R-HSA-5682847) H2AFX [extracellular region] (R-HSA-977583)	0.527	2
UniProt:P33993 MCM7	1	MCM7 [nucleoplasm] (R-HSA-68555)	0.527	3
UniProt:P78368 CSNK1G2	2	CSNK1G2 [cytosol] (R-HSA-429696) CSNK1G2 [plasma membrane] (R-HSA-205718)	0.527	2

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