3,5,3'-triiodothyronine + PAPS => 3,5,3'-triiodothyronine 4-sulfate + PAP

Stable Identifier
Reaction [transition]
Homo sapiens
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3,5,3'-Triiodothyronine (T3) 4-sulfate is a major metabolite of T3 in humans (LoPresti and Nicoloff 1994), and seven SULT enzymes, SULT1A1 (Li et al. 2001), 1A3 (Kester, Kaptein et al. 1999), 1B1 (Wang et al. 1998), 1C1 (Li et al. 2000), 1E1 (Li and Anderson 1999; Kester, van Dijk et al. 1999), 2A1 (Li and Anderson 1999), and 4A1 (Sakakibara et al. 2002) can catalyze this reaction in vitro or in tissue culture model systems. All of these enzymes except SULT4A1 also catalyze the sulfonation of 3,3'-diiodothyronine (T2).
Literature References
PubMed ID Title Journal Year
10512730 Sulfation of iodothyronines by recombinant human liver steroid sulfotransferases

Anderson, RJ, Li, X

Biochem Biophys Res Commun 1999
9463486 Expression and characterization of a novel thyroid hormone-sulfating form of cytosolic sulfotransferase from human liver

Falany, JL, Falany, CN, Wang, J

Mol Pharmacol 1998
11077054 Sulfation of iodothyronines by human sulfotransferase 1C1 (SULT1C1)*

Anderson, RJ, Clemens, DL, Li, X

Biochem Pharmacol 2000
10199779 Characterization of human iodothyronine sulfotransferases

Roest, TJ, Kaptein, E, van Dijk, CH, Glatt, H, Tibboel, D, Visser, TJ, Kester, MH, Coughtrie, MW, Meinl, W

J Clin Endocrinol Metab 1999
12039030 Highly conserved mouse and human brain sulfotransferases: molecular cloning, expression, and functional characterization

Liu, MC, Nakayama, T, Pai, TG, Suiko, M, Takami, Y, Sakakibara, Y, Katafuchi, J

Gene 2002
11739018 Characterization of human liver thermostable phenol sulfotransferase (SULT1A1) allozymes with 3,3',5-triiodothyronine as the substrate

Anderson, RJ, Clemens, DL, Li, X, Cole, JR

J Endocrinol 2001
Catalyst Activity

aryl sulfotransferase activity of SULT dimers (T3) [cytosol]

Orthologous Events
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