3,5,3'-triiodothyronine + PAPS => 3,5,3'-triiodothyronine 4-sulfate + PAP

Stable Identifier
R-HSA-176585
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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3,5,3'-Triiodothyronine (T3) 4-sulfate is a major metabolite of T3 in humans (LoPresti and Nicoloff 1994), and seven SULT enzymes, SULT1A1 (Li et al. 2001), 1A3 (Kester, Kaptein et al. 1999), 1B1 (Wang et al. 1998), 1C1 (Li et al. 2000), 1E1 (Li and Anderson 1999; Kester, van Dijk et al. 1999), 2A1 (Li and Anderson 1999), and 4A1 (Sakakibara et al. 2002) can catalyze this reaction in vitro or in tissue culture model systems. All of these enzymes except SULT4A1 also catalyze the sulfonation of 3,3'-diiodothyronine (T2).

Literature References
PubMed ID Title Journal Year
9463486 Expression and characterization of a novel thyroid hormone-sulfating form of cytosolic sulfotransferase from human liver

Wang, J, Falany, JL, Falany, CN

Mol Pharmacol 1998
10512730 Sulfation of iodothyronines by recombinant human liver steroid sulfotransferases

Li, X, Anderson, RJ

Biochem Biophys Res Commun 1999
11077054 Sulfation of iodothyronines by human sulfotransferase 1C1 (SULT1C1)*

Li, X, Clemens, DL, Anderson, RJ

Biochem Pharmacol 2000
10199779 Characterization of human iodothyronine sulfotransferases

Kester, MH, Kaptein, E, Roest, TJ, van Dijk, CH, Tibboel, D, Meinl, W, Glatt, H, Coughtrie, MW, Visser, TJ

J Clin Endocrinol Metab 1999
12039030 Highly conserved mouse and human brain sulfotransferases: molecular cloning, expression, and functional characterization

Sakakibara, Y, Suiko, M, Pai, TG, Nakayama, T, Takami, Y, Katafuchi, J, Liu, MC

Gene 2002
11739018 Characterization of human liver thermostable phenol sulfotransferase (SULT1A1) allozymes with 3,3',5-triiodothyronine as the substrate

Li, X, Clemens, DL, Cole, JR, Anderson, RJ

J Endocrinol 2001
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
aryl sulfotransferase activity of SULT dimers (T3) [cytosol]
Physical Entity
Activity
Orthologous Events
Reviewed
Created
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