beta-estradiol + PAPS => beta-estradiol 3-sulfate + PAP

Stable Identifier
R-HSA-176521
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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beta-estradiol + PAPS => beta-estradiol 3-sulfate + PAP
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Sulfonation of beta-estradiol (EST17b) is catalyzed by SULT1E1 (Falany et al. 1995).
Literature References
PubMed ID Title Journal Year
7779757 Bacterial expression and characterization of a cDNA for human liver estrogen sulfotransferase

Falany, CN, Krasnykh, V, Falany, JL

J Steroid Biochem Mol Biol 1995
Participants
Input
Output
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as an event of
Catalyst Activity

steroid sulfotransferase activity of SULT1E1 dimer [cytosol]

Physical Entity
SULT1E1 dimer [cytosol] (Homo sapiens)
Activity
steroid sulfotransferase activity (GO:0050294)
Orthologous Events
beta-estradiol + PAPS => beta-estradiol 3-sulfate + PAP (Bos taurus)
beta-estradiol + PAPS => beta-estradiol 3-sulfate + PAP (Canis familiaris)
beta-estradiol + PAPS => beta-estradiol 3-sulfate + PAP (Danio rerio)
beta-estradiol + PAPS => beta-estradiol 3-sulfate + PAP (Gallus gallus)
beta-estradiol + PAPS => beta-estradiol 3-sulfate + PAP (Mus musculus)
beta-estradiol + PAPS => beta-estradiol 3-sulfate + PAP (Rattus norvegicus)
beta-estradiol + PAPS => beta-estradiol 3-sulfate + PAP (Sus scrofa)
beta-estradiol + PAPS => beta-estradiol 3-sulfate + PAP (Xenopus tropicalis)
Cross References
RHEA
Reviewed
D'Eustachio, P  (2008-05-28)
Hill, DP  (2025-10-09)
Created
D'Eustachio, P  (2006-03-09)
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