3,3'-diiodothyronine + PAPS => 3,3'-diiodothyronine 4-sulfate + PAP

Stable Identifier
Reaction [transition]
Homo sapiens
Locations in the PathwayBrowser
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Six SULT enzymes, SULT1A1 (Li et al. 2001), 1A3 (Kester, Kaptein et al. 1999), 1B1 (Wang et al. 1998), 1C1 (Li et al. 2000), 1E1 (Li and Anderson 1999; Kester, van Dijk et al. 1999), and 2A1 (Li and Anderson 1999), can catalyze the sulfonation of 3,3'-diiodothyronine (T2) in vitro or in tissue culture model systems. These six enzymes also catalyze the sulfonation of 3,5,3'-triiodothyronine (T3).
Literature References
PubMed ID Title Journal Year
10512730 Sulfation of iodothyronines by recombinant human liver steroid sulfotransferases

Anderson, RJ, Li, X

Biochem Biophys Res Commun 1999
9463486 Expression and characterization of a novel thyroid hormone-sulfating form of cytosolic sulfotransferase from human liver

Falany, JL, Falany, CN, Wang, J

Mol Pharmacol 1998
11077054 Sulfation of iodothyronines by human sulfotransferase 1C1 (SULT1C1)*

Anderson, RJ, Clemens, DL, Li, X

Biochem Pharmacol 2000
10199779 Characterization of human iodothyronine sulfotransferases

Roest, TJ, Kaptein, E, van Dijk, CH, Glatt, H, Tibboel, D, Visser, TJ, Kester, MH, Coughtrie, MW, Meinl, W

J Clin Endocrinol Metab 1999
11739018 Characterization of human liver thermostable phenol sulfotransferase (SULT1A1) allozymes with 3,3',5-triiodothyronine as the substrate

Anderson, RJ, Clemens, DL, Li, X, Cole, JR

J Endocrinol 2001
Catalyst Activity

aryl sulfotransferase activity of SULT dimers (T2) [cytosol]

Orthologous Events
Cite Us!