3,3'-diiodothyronine + PAPS => 3,3'-diiodothyronine 4-sulfate + PAP

Stable Identifier
R-HSA-176474
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Six SULT enzymes, SULT1A1 (Li et al. 2001), 1A3 (Kester, Kaptein et al. 1999), 1B1 (Wang et al. 1998), 1C1 (Li et al. 2000), 1E1 (Li and Anderson 1999; Kester, van Dijk et al. 1999), and 2A1 (Li and Anderson 1999), can catalyze the sulfonation of 3,3'-diiodothyronine (T2) in vitro or in tissue culture model systems. These six enzymes also catalyze the sulfonation of 3,5,3'-triiodothyronine (T3).

Literature References
PubMed ID Title Journal Year
9463486 Expression and characterization of a novel thyroid hormone-sulfating form of cytosolic sulfotransferase from human liver

Wang, J, Falany, JL, Falany, CN

Mol Pharmacol 1998
10512730 Sulfation of iodothyronines by recombinant human liver steroid sulfotransferases

Li, X, Anderson, RJ

Biochem Biophys Res Commun 1999
11077054 Sulfation of iodothyronines by human sulfotransferase 1C1 (SULT1C1)*

Li, X, Clemens, DL, Anderson, RJ

Biochem Pharmacol 2000
10199779 Characterization of human iodothyronine sulfotransferases

Kester, MH, Kaptein, E, Roest, TJ, van Dijk, CH, Tibboel, D, Meinl, W, Glatt, H, Coughtrie, MW, Visser, TJ

J Clin Endocrinol Metab 1999
11739018 Characterization of human liver thermostable phenol sulfotransferase (SULT1A1) allozymes with 3,3',5-triiodothyronine as the substrate

Li, X, Clemens, DL, Cole, JR, Anderson, RJ

J Endocrinol 2001
Participants
Participates
Catalyst Activity

aryl sulfotransferase activity of SULT dimers (T2) [cytosol]

Orthologous Events
Reviewed
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