Reactome | 3,3'-diiodothyronine + PAPS => 3,3'-diiodothyronine 4-sulfate + PAP

3,3'-diiodothyronine + PAPS => 3,3'-diiodothyronine 4-sulfate + PAP

Stable Identifier

R-HSA-176474

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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3,3'-diiodothyronine + PAPS => 3,3'-diiodothyronine 4-sulfate + PAP

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Six SULT enzymes, SULT1A1 (Li et al. 2001), 1A3 (Kester, Kaptein et al. 1999), 1B1 (Wang et al. 1998), 1C1 (Li et al. 2000), 1E1 (Li and Anderson 1999; Kester, van Dijk et al. 1999), and 2A1 (Li and Anderson 1999), can catalyze the sulfonation of 3,3'-diiodothyronine (T2) in vitro or in tissue culture model systems. These six enzymes also catalyze the sulfonation of 3,5,3'-triiodothyronine (T3).

Literature References

PubMed ID	Title	Journal	Year
10512730	Sulfation of iodothyronines by recombinant human liver steroid sulfotransferases Li, X, Anderson, RJ	Biochem Biophys Res Commun	1999
9463486	Expression and characterization of a novel thyroid hormone-sulfating form of cytosolic sulfotransferase from human liver Wang, J, Falany, JL, Falany, CN	Mol Pharmacol	1998
11077054	Sulfation of iodothyronines by human sulfotransferase 1C1 (SULT1C1)* Li, X, Clemens, DL, Anderson, RJ	Biochem Pharmacol	2000
10199779	Characterization of human iodothyronine sulfotransferases Kester, MH, Kaptein, E, Roest, TJ, van Dijk, CH, Tibboel, D, Meinl, W, Glatt, H, Coughtrie, MW, Visser, TJ	J Clin Endocrinol Metab	1999
11739018	Characterization of human liver thermostable phenol sulfotransferase (SULT1A1) allozymes with 3,3',5-triiodothyronine as the substrate Li, X, Clemens, DL, Cole, JR, Anderson, RJ	J Endocrinol	2001