Reactome | RAD9A [nucleoplasm]

RAD9A [nucleoplasm]

Stable Identifier

R-HSA-176372

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

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Locations in the PathwayBrowser

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Cell Cycle (Homo sapiens)

- Cell Cycle Checkpoints (Homo sapiens)
  - G2/M Checkpoints (Homo sapiens)
    - Activation of ATR in response to replication stress (Homo sapiens)
      - Recruitment of the Rad9-Hus1-Rad1 complex to DNA (Homo sapiens)
        
        RAD9:HUS1:RAD1 [nucleoplasm] (Homo sapiens)
        
        RAD9 [nucleoplasm] (Homo sapiens)
        
        RAD9A [nucleoplasm] (Homo sapiens)
        
        Rad9-Hus1-Rad1 bound to DNA [nucleoplasm] (Homo sapiens)
        
        RAD9:HUS1:RAD1 [nucleoplasm] (Homo sapiens)
        
        RAD9 [nucleoplasm] (Homo sapiens)
        
        RAD9A [nucleoplasm] (Homo sapiens)
    - G2/M DNA damage checkpoint (Homo sapiens)
      - ATR phosphorylates TP53 (Homo sapiens)
        
        ATR:ATRIP:RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
        
        RAD9:HUS1:RAD1 [nucleoplasm] (Homo sapiens)
        
        RAD9 [nucleoplasm] (Homo sapiens)
        
        RAD9A [nucleoplasm] (Homo sapiens)

DNA Repair (Homo sapiens)

- DNA Double-Strand Break Repair (Homo sapiens)
  - Homology Directed Repair (Homo sapiens)
    - HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) (Homo sapiens)
      - HDR through Homologous Recombination (HRR) (Homo sapiens)
        
        Homologous DNA Pairing and Strand Exchange (Homo sapiens)
        
        Presynaptic phase of homologous DNA pairing and strand exchange (Homo sapiens)
        
        RAD51 binds BRCA2 at resected DNA DSBs (Homo sapiens)
        
        ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
        
        RAD9:HUS1:RAD1 [nucleoplasm] (Homo sapiens)
        
        RAD9 [nucleoplasm] (Homo sapiens)
        
        RAD9A [nucleoplasm] (Homo sapiens)
        
        RAD9:HUS1:RAD1 [nucleoplasm] (Homo sapiens)
        
        RAD9 [nucleoplasm] (Homo sapiens)
        
        RAD9A [nucleoplasm] (Homo sapiens)
      - HDR through Single Strand Annealing (SSA) (Homo sapiens)
        
        Association of RAD51 with RAD52:DNA double-strand break ends (Homo sapiens)
        
        RAD51:p-Y104-RAD52:p-RPA:ATR:ATRIP:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
        
        p-Y104-RAD52:p-RPA:ATR:ATRIP:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
        
        ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
        
        RAD9:HUS1:RAD1 [nucleoplasm] (Homo sapiens)
        
        RAD9 [nucleoplasm] (Homo sapiens)
        
        RAD9A [nucleoplasm] (Homo sapiens)
        
        p-Y104-RAD52:p-RPA:ATR:ATRIP:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
        
        ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
        
        RAD9:HUS1:RAD1 [nucleoplasm] (Homo sapiens)
        
        RAD9 [nucleoplasm] (Homo sapiens)
        
        RAD9A [nucleoplasm] (Homo sapiens)
        
        Association of RAD52 with the RPA complex at resected DNA DSBs (Homo sapiens)
        
        ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
        
        RAD9:HUS1:RAD1 [nucleoplasm] (Homo sapiens)
        
        RAD9 [nucleoplasm] (Homo sapiens)
        
        RAD9A [nucleoplasm] (Homo sapiens)
        
        p-Y104-RAD52:p-RPA:ATR:ATRIP:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
        
        ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
        
        RAD9:HUS1:RAD1 [nucleoplasm] (Homo sapiens)
        
        RAD9 [nucleoplasm] (Homo sapiens)
        
        RAD9A [nucleoplasm] (Homo sapiens)
        
        ERCC1:XPF cleaves flaps generated by SSA (Homo sapiens)
        
        RAD51:p-Y104-RAD52:p-RPA:ATR:ATRIP:DNA DSBs with annealed 3' ssDNA overhangs and displaced flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
        
        p-Y104-RAD52:p-RPA:ATR:ATRIP:DNA DSBs with annealed 3' ssDNA overhangs and displaced flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
        
        ATR:ATRIP:p-RPA:DNA DSBs with annealed 3' ssDNA overhangs and displaced flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
        
        RAD9:HUS1:RAD1 [nucleoplasm] (Homo sapiens)
        
        RAD9 [nucleoplasm] (Homo sapiens)
        
        RAD9A [nucleoplasm] (Homo sapiens)
        
        RAD9:HUS1:RAD1 [nucleoplasm] (Homo sapiens)
        
        RAD9 [nucleoplasm] (Homo sapiens)
        
        RAD9A [nucleoplasm] (Homo sapiens)
        
        RAD52 promotes single strand annealing at resected DNA DSBs (Homo sapiens)
        
        RAD51:p-Y104-RAD52:p-RPA:ATR:ATRIP:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
        
        p-Y104-RAD52:p-RPA:ATR:ATRIP:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
        
        ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
        
        RAD9:HUS1:RAD1 [nucleoplasm] (Homo sapiens)
        
        RAD9 [nucleoplasm] (Homo sapiens)
        
        RAD9A [nucleoplasm] (Homo sapiens)
        
        RAD51:p-Y104-RAD52:p-RPA:ATR:ATRIP:DNA DSBs with annealed 3' ssDNA overhangs and displaced flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
        
        p-Y104-RAD52:p-RPA:ATR:ATRIP:DNA DSBs with annealed 3' ssDNA overhangs and displaced flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
        
        ATR:ATRIP:p-RPA:DNA DSBs with annealed 3' ssDNA overhangs and displaced flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
        
        RAD9:HUS1:RAD1 [nucleoplasm] (Homo sapiens)
        
        RAD9 [nucleoplasm] (Homo sapiens)
        
        RAD9A [nucleoplasm] (Homo sapiens)
      - Processing of DNA double-strand break ends (Homo sapiens)
        
        ATR activation at DNA DSBs (Homo sapiens)
        
        ATR:ATRIP:RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
        
        RAD9:HUS1:RAD1 [nucleoplasm] (Homo sapiens)
        
        RAD9 [nucleoplasm] (Homo sapiens)
        
        RAD9A [nucleoplasm] (Homo sapiens)
        
        RAD9:HUS1:RAD1 [nucleoplasm] (Homo sapiens)
        
        RAD9 [nucleoplasm] (Homo sapiens)
        
        RAD9A [nucleoplasm] (Homo sapiens)
        
        ATR phosphorylates RPA2 (Homo sapiens)
        
        ATR:ATRIP:RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
        
        RAD9:HUS1:RAD1 [nucleoplasm] (Homo sapiens)
        
        RAD9 [nucleoplasm] (Homo sapiens)
        
        RAD9A [nucleoplasm] (Homo sapiens)
        
        ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
        
        RAD9:HUS1:RAD1 [nucleoplasm] (Homo sapiens)
        
        RAD9 [nucleoplasm] (Homo sapiens)
        
        RAD9A [nucleoplasm] (Homo sapiens)
        
        Activation of CHEK1 at resected DNA DSBs (Homo sapiens)
        
        ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
        
        RAD9:HUS1:RAD1 [nucleoplasm] (Homo sapiens)
        
        RAD9 [nucleoplasm] (Homo sapiens)
        
        RAD9A [nucleoplasm] (Homo sapiens)
        
        ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1:TIMELESS:TIPIN:p-T916,S945-CLSPN:CHEK1 [nucleoplasm] (Homo sapiens)
        
        RAD9:HUS1:RAD1 [nucleoplasm] (Homo sapiens)
        
        RAD9 [nucleoplasm] (Homo sapiens)
        
        RAD9A [nucleoplasm] (Homo sapiens)
        
        CHEK1 is recruited to resected DNA DSBs (Homo sapiens)
        
        ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
        
        RAD9:HUS1:RAD1 [nucleoplasm] (Homo sapiens)
        
        RAD9 [nucleoplasm] (Homo sapiens)
        
        RAD9A [nucleoplasm] (Homo sapiens)
        
        ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1:TIMELESS:TIPIN:p-T916,S945-CLSPN:CHEK1 [nucleoplasm] (Homo sapiens)
        
        RAD9:HUS1:RAD1 [nucleoplasm] (Homo sapiens)
        
        RAD9 [nucleoplasm] (Homo sapiens)
        
        RAD9A [nucleoplasm] (Homo sapiens)

Disease (Homo sapiens)

- Diseases of DNA repair (Homo sapiens)
  - Diseases of DNA Double-Strand Break Repair (Homo sapiens)
    - Defective homologous recombination repair (HRR) due to BRCA2 loss of function (Homo sapiens)
      - Impaired BRCA2 binding to RAD51 (Homo sapiens)
        
        BRCA2 mutants with BRC defects or a defect in the C-terminal RAD51 binding site do not bind RAD51 (Homo sapiens)
        
        ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
        
        RAD9:HUS1:RAD1 [nucleoplasm] (Homo sapiens)
        
        RAD9 [nucleoplasm] (Homo sapiens)
        
        RAD9A [nucleoplasm] (Homo sapiens)

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - Regulation of TP53 Activity (Homo sapiens)
        
        Regulation of TP53 Activity through Phosphorylation (Homo sapiens)
        
        ATR phosphorylates TP53 (Homo sapiens)
        
        ATR:ATRIP:RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Homo sapiens)
        
        RAD9:HUS1:RAD1 [nucleoplasm] (Homo sapiens)
        
        RAD9 [nucleoplasm] (Homo sapiens)
        
        RAD9A [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q99638 RAD9A

Gene Names

RAD9A

Chain

chain:1-391

Reference Genes

BioGPS Gene:5883 RAD9A

COSMIC (genes):RAD9A RAD9A

CTD Gene:5883 RAD9A

dbSNP Gene:5883 RAD9A

ENSEMBL:ENSG00000172613 RAD9A

HGNC:9827 RAD9A

KEGG:hsa:5883 RAD9A

Monarch:5883 RAD9A

NCBI Gene:5883 RAD9A

OMIM:603761 RAD9A

UCSC:Q99638 RAD9A

Reference Transcript

Other Identifiers

11724874_at

1324_at

1562022_3p_s_at

1562022_PM_s_at

1562022_s_at

16727795

16727802

204828_PM_at

204828_at

32158_at

3336952

3336953

3336954

3336957

3336972

3336975

3336976

3336977

3336978

3336979

3336980

3336981

3336982

3336983

3336984

3336985

3336986

3336987

3336989

3336990

3336991

3336992

3336993

3336994

3336995

3336996

3336997

3336998

3336999

3337000

3337001

3337013

5883

7941865

88802_at

A_14_P125850

A_14_P129363

A_14_P139630

A_23_P12920

A_24_P21715

A_33_P3281171

GE482161

GE79312

GO:0000076

GO:0000077

GO:0003824

GO:0004527

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0006281

GO:0006974

GO:0008311

GO:0008408

GO:0008630

GO:0016787

GO:0017124

GO:0019899

GO:0019901

GO:0030896

GO:0031573

GO:0042826

GO:0043226

GO:0071479

GO:0140097

GO:1902231

HMNXSV003002722

HMNXSV003007227

Hs2.124427.1.S1_3p_s_at

ILMN_1684183

PH_hs_0012926

PH_hs_0034853

TC11000685.hg

TC11000687.hg

TC11002737.hg

U53174_at

g4759021_3p_at

p24895

Participates

as a member of

RAD9 [nucleoplasm] (Homo sapiens)

Inferred To

DDC1 [nucleoplasm] (Saccharomyces cerevisiae)

RAD9A [nucleoplasm] (Bos taurus)

RAD9A [nucleoplasm] (Canis familiaris)

RAD9A [nucleoplasm] (Sus scrofa)

rad9a [nucleoplasm] (Xenopus tropicalis)

Rad9 [nucleoplasm] (Drosophila melanogaster)

Rad9a [nucleoplasm] (Mus musculus)

Rad9a [nucleoplasm] (Rattus norvegicus)

rad9 [nucleoplasm] (Dictyostelium discoideum)

rad9 [nucleoplasm] (Gallus gallus)

rad9 [nucleoplasm] (Schizosaccharomyces pombe)

hpr-9 [nucleoplasm] (Caenorhabditis elegans)

Cross References

RefSeq

NP_004575.1, NP_001230153.1

ENSEMBL

ENST00000307980, ENSP00000311360, ENSG00000172613

OpenTargets

ENSG00000172613

GeneCards

RAD9A

HPA

ENSG00000172613-RAD9A

PRO

Q99638

Pharos - Targets

Q99638

PDB

6HM5, 7Z6H, 3G65, 8GNN, 3GGR, 6J8Y, 3A1J, 8WU8, 8JZY

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