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Association of Ku heterodimer with viral DNA ends
Stable Identifier
R-HSA-175174
Type
Reaction [transition]
Species
Homo sapiens
Related Species
Human immunodeficiency virus 1
Compartment
nucleoplasm
ReviewStatus
5/5
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HIV Infection (Homo sapiens)
HIV Life Cycle (Homo sapiens)
Early Phase of HIV Life Cycle (Homo sapiens)
Integration of provirus (Homo sapiens)
2-LTR circle formation (Homo sapiens)
Association of Ku heterodimer with viral DNA ends (Homo sapiens)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
The Ku protein can be found bound to active PICs in the cytoplasm. However, ligation of the viral DNA ends to form 2-LTR circles takes place in the nucleus.
Literature References
PubMed ID
Title
Journal
Year
Retroviruses
Varmus, HE
,
Hughes, SH
,
Coffin, JM
1997
Participants
Input
IN bound to sticky 3' ends of viral DNA in PIC [nucleoplasm]
(Homo sapiens)
XRCC5:XRCC6 [nucleoplasm]
(Homo sapiens)
Output
Ku proteins bound to viral DNA [nucleoplasm]
(Homo sapiens)
viral PIC proteins [nucleoplasm]
(Homo sapiens)
Participates
as an event of
2-LTR circle formation (Homo sapiens)
Disease
Name
Identifier
Synonyms
Human immunodeficiency virus infectious disease
DOID:526
HIV infection
Authored
D'Eustachio, P (2006-05-19)
Gopinathrao, G (2006-05-19)
Reviewed
Bushman, FD (2006-10-31)
Created
Gopinathrao, G (2006-02-24)
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