Formation of N-glucuronides

Stable Identifier
R-HSA-174916
Type
Reaction [transition]
Species
Homo sapiens
Compartment
endoplasmic reticulum lumen, endoplasmic reticulum membrane
ReviewStatus
5/5
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Formation of N-glucuronides
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Typical N-centred substrates were chosen as examples for these isozymes.
Literature References
PubMed ID Title Journal Year
12433823 Characterization of nicotine and cotinine N-glucuronidations in human liver microsomes

Nakajima, M, Tanaka, E, Kwon, JT, Yokoi, T

Drug Metab Dispos 2002
14570768 N-glucuronidation of nicotine and cotinine by human liver microsomes and heterologously expressed UDP-glucuronosyltransferases

Kuehl, GE, Murphy, SE

Drug Metab Dispos 2003
15135306 Quaternary ammonium-linked glucuronidation of tamoxifen by human liver microsomes and UDP-glucuronosyltransferase 1A4

Kaku, T, Ogura, K, Nishiyama, T, Ohnuma, T, Muro, K, Hiratsuka, A

Biochem Pharmacol 2004
Participants
Input
Output
Participates
as an event of
Catalyst Activity

glucuronosyltransferase activity of UGT1A3,A4,A9 [endoplasmic reticulum membrane]

Physical Entity
UGT1A3,A4,A9 [endoplasmic reticulum membrane] (Homo sapiens)
Activity
glucuronosyltransferase activity (GO:0015020)
Orthologous Events
Formation of N-glucuronides (Mus musculus)
Formation of N-glucuronides (Rattus norvegicus)
Reviewed
D'Eustachio, P  (2008-05-28)
Created
Jassal, B  (2006-02-23)
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