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POT1 [nucleoplasm]
Stable Identifier
R-HSA-174890
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Locations in the PathwayBrowser for interactor UniProt:Q9NYB0 TERF2IP
Expand all
Cell Cycle (Homo sapiens)
Chromosome Maintenance (Homo sapiens)
Telomere Maintenance (Homo sapiens)
Packaging Of Telomere Ends (Homo sapiens)
Incorporation Of Extended And Processed Telomere End Into Associated Protein Structure (Homo sapiens)
POT1 [nucleoplasm] (Homo sapiens)
Incorporation Of Extended And Processed Telomere End Into Higher Order T-Loop And Associated Protein Structure (Homo sapiens)
POT1 [nucleoplasm] (Homo sapiens)
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular Senescence (Homo sapiens)
DNA Damage/Telomere Stress Induced Senescence (Homo sapiens)
Telomere shortening during replicative exhaustion (Homo sapiens)
POT1 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9NUX5 POT1
Gene Names
POT1
Chain
chain:1-634
Reference Genes
BioGPS Gene:25913 POT1
COSMIC (genes):POT1 POT1
CTD Gene:25913 POT1
dbSNP Gene:25913 POT1
ENSEMBL:ENSG00000128513 POT1
HGNC:17284 POT1
KEGG Gene (Homo sapiens):25913 POT1
Monarch:25913 POT1
NCBI Gene:25913 POT1
OMIM:606478 POT1
UCSC:Q9NUX5 POT1
Reference Transcript
RefSeq:NM_001042594.1 POT1
RefSeq:NM_015450.2 POT1
RefSeq:XM_006715917.3 POT1
Other Identifiers
0000380377
11733079_a_at
11733080_a_at
11741651_a_at
17062502
204353_s_at
204354_at
25913
3070909
3070910
3070911
3070912
3070913
3070914
3070916
3070917
3070918
3070919
3070921
3070922
3070923
3070925
3070928
3070929
3070930
3070933
3070934
3070935
3070936
3070937
3070938
3070939
3070940
3070943
3070944
3070945
3070946
3070947
39653_at
8142697
A_23_P84610
A_24_P309105
A_33_P3882624
GE55722
GE84567
GO:0000723
GO:0000781
GO:0000783
GO:0003674
GO:0003677
GO:0005515
GO:0005575
GO:0005622
GO:0005634
GO:0005654
GO:0005694
GO:0006259
GO:0006950
GO:0007004
GO:0007049
GO:0008150
GO:0009058
GO:0010521
GO:0016233
GO:0017151
GO:0019899
GO:0022607
GO:0030234
GO:0032201
GO:0032202
GO:0032210
GO:0032211
GO:0032212
GO:0032508
GO:0032991
GO:0034641
GO:0042162
GO:0042592
GO:0043047
GO:0043226
GO:0045007
GO:0048239
GO:0051096
GO:0051276
GO:0051973
GO:0051974
GO:0060383
GO:0061820
GO:0061821
GO:0070187
GO:0070200
GO:0098505
GO:1900051
GO:1905773
GO:1905774
GO:1905776
GO:1990955
GO:2001032
HMNXSV003021191
ILMN_1692041
ILMN_2327203
PH_hs_0002716
TC07001830.hg
TC07003148.hg
g12804138_3p_a_at
g13123773_3p_at
Participates
as a component of
AP-Telomeric DNA:Shelterin [nucleoplasm] (Homo sapiens)
Extended And Processed Telomere End and Associated DNA Binding and Packaging Protein Complex [nucleoplasm] (Homo sapiens)
Extended And Processed Telomere End and Associated DNA Binding and Packaging Protein Complex Folded Into Higher Order Structure [nucleoplasm] (Homo sapiens)
Gh-Telomeric DNA:Shelterin [nucleoplasm] (Homo sapiens)
Shelterin complex (p-S365-TERF2) [nucleoplasm] (Homo sapiens)
Shelterin complex [nucleoplasm] (Homo sapiens)
Sp-Telomeric DNA:Shelterin [nucleoplasm] (Homo sapiens)
Telomere:Shelterin:Nucleosome (H3F3A) [nucleoplasm] (Homo sapiens)
Tg-Telomeric DNA:Shelterin [nucleoplasm] (Homo sapiens)
as an input of
Incorporation Of Extended And Processed Telomere End Into Associated Protein Structure (Homo sapiens)
Incorporation Of Extended And Processed Telomere End Into Higher Order T-Loop And Associated Protein Structure (Homo sapiens)
as an output of
Telomere shortening during replicative exhaustion (Homo sapiens)
Inferred To
Pot1 [nucleoplasm]
(Mus musculus)
Pot1 [nucleoplasm]
(Rattus norvegicus)
Ghost homologue of POT1 [nucleoplasm]
(Gallus gallus)
pot1 [nucleoplasm]
(Danio rerio)
pot1 [nucleoplasm]
(Schizosaccharomyces pombe)
pot1 [nucleoplasm]
(Xenopus tropicalis)
POT1 [nucleoplasm]
(Bos taurus)
POT1 [nucleoplasm]
(Canis familiaris)
POT1 [nucleoplasm]
(Sus scrofa)
Cross References
RefSeq
NP_056265.2
,
XP_006715980.1
,
NP_001036059.1
OpenTargets
ENSG00000128513
HPA
ENSG00000128513-POT1
GeneCards
Q9NUX5
Ensembl
ENST00000357628
,
ENST00000664366
,
ENSP00000499290
,
ENSP00000499546
,
ENSP00000499635
,
ENSP00000499476
,
ENST00000653241
,
ENST00000655761
,
ENSG00000128513
,
ENSP00000350249
,
ENST00000668382
ZINC target
Q9NUX5
PRO
Q9NUX5
Pharos - Targets
Q9NUX5
Orphanet
22138
PDB
3KJP
,
5H65
,
3KJO
,
5UN7
,
1XJV
Interactors (41)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q96AP0 ACD
1
ACD [nucleoplasm]
(R-HSA-174889)
0.89
9
UniProt:Q15554 TERF2
2
p-S365-TERF2 [nucleoplasm]
(R-HSA-9686530)
TERF2 [nucleoplasm]
(R-HSA-174895)
0.802
7
UniProt:Q9NYB0 TERF2IP
1
TERF2IP [nucleoplasm]
(R-HSA-174873)
0.643
4
UniProt:Q9Y281 COF2
0.556
3
UniProt:Q549N0 Q549N0
0.556
3
UniProt:Q9BSI4 TINF2
1
TINF2 [nucleoplasm]
(R-HSA-174883)
0.547
3
UniProt:Q9BSI4-2 TINF2
0.527
2
UniProt:P54274-2 TERF1
0.527
2
UniProt:P63313 TYB10
0.508
2
UniProt:Q99795 GPA33
0.508
2
UniProt:Q9BR01 SULT4A1
1
SULT4A1 [cytosol]
(R-HSA-176668)
0.508
2
UniProt:Q9BY11 PACSIN1
1
PACSIN1 [cytosol]
(R-HSA-8868269)
0.508
2
UniProt:Q9BRP8 PYM1
0.508
2
UniProt:P30838 ALDH3A1
1
ALDH3A1 [cytosol]
(R-HSA-5692291)
0.508
2
UniProt:Q01064 PDE1B
2
activated PDE1B [cytosol]
(R-HSA-9014908)
PDE1B [cytosol]
(R-HSA-52371)
0.508
2
UniProt:Q96GU1 PAGE5
0.508
2
UniProt:P46952 HAAO
1
HAAO [cytosol]
(R-HSA-71085)
0.508
2
UniProt:Q8IUZ5 PHYKPL
1
PXLP-K278-PHYKPL [mitochondrial matrix]
(R-HSA-5696428)
0.508
2
UniProt:Q96A49 SYAP1
0.508
2
UniProt:Q5SRE7 PHYD1
0.508
2
UniProt:P09601 HMOX1
4
HMOX1 [mitochondrial outer membrane]
(R-HSA-9708524)
HMOX1 [nucleoplasm]
(R-HSA-9708567)
HMOX1 [cytosol]
(R-HSA-9609901)
HMOX1 [endoplasmic reticulum membrane]
(R-HSA-189395)
0.508
2
UniProt:Q9BWH6 RPAP1
0.508
2
UniProt:O60496 DOK2
1
DOK2 [cytosol]
(R-HSA-204823)
0.508
2
UniProt:O43704 SULT1B1
1
SULT1B1 [cytosol]
(R-HSA-176551)
0.508
2
UniProt:Q03426 MVK
1
MVK [cytosol]
(R-HSA-191375)
0.508
2
UniProt:Q6PJW8 CNST
0.508
2
UniProt:Q86WR7 PRSR2
0.508
2
UniProt:Q9NPH2 ISYNA1
1
ISYNA1 [cytosol]
(R-HSA-1604599)
0.508
2
UniProt:O95833 CLIC3
0.508
2
UniProt:Q9Y4P8 WIPI2
1
WIPI2 [cytosol]
(R-HSA-5678305)
0.508
2
UniProt:Q9BV29 CCD32
0.508
2
UniProt:Q8WXG6 MADD
0.508
2
UniProt:P43358 MAGA4
0.508
2
UniProt:O94808 GFPT2
1
GFPT2 [cytosol]
(R-HSA-532208)
0.508
2
UniProt:Q96A73 P33MX
0.508
2
UniProt:Q12851 M4K2
0.508
2
UniProt:Q9P0Z9 PIPOX
2
PIPOX [peroxisomal matrix]
(R-HSA-452911)
PIPOX [cytosol]
(R-HSA-9033136)
0.508
2
UniProt:P50747 HLCS
8
HLCS L216R [cytosol]
(R-HSA-3325513)
HLCS [cytosol]
(R-HSA-2993867)
HLCS D571N [cytosol]
(R-HSA-3325499)
HLCS L237P [cytosol]
(R-HSA-3325514)
HLCS V550M [cytosol]
(R-HSA-3325460)
HLCS G261Vfs*20 [cytosol]
(R-HSA-3325463)
HLCS R508W [cytosol]
(R-HSA-3325442)
HLCS G581S [cytosol]
(R-HSA-3325506)
0.508
2
UniProt:P0DMV8 HSPA1A
4
HSPA1A [nucleoplasm]
(R-HSA-6792605)
HSPA1A [cytosol]
(R-HSA-6792602)
HSPA1A [extracellular region]
(R-HSA-6805872)
HSPA1A [ficolin-1-rich granule lumen]
(R-HSA-6801496)
0.508
2
UniProt:P07355 ANXA2
4
ANXA2 [external side of plasma membrane]
(R-HSA-5336164)
ANXA2 [cytosol]
(R-HSA-5263667)
ANXA2 [extracellular region]
(R-HSA-6806242)
ANXA2 [azurophil granule lumen]
(R-HSA-6798766)
0.508
2
UniProt:P05783 KRT18
1
KRT18 [cytosol]
(R-HSA-201582)
0.488
2
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