Reactome | MTTP [endoplasmic reticulum lumen]

MTTP [endoplasmic reticulum lumen]

Stable Identifier

R-HSA-174688

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endoplasmic reticulum lumen

Synonyms

MTP, microsomal triglyceride transfer protein

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P55157 MTTP

Gene Names

MTTP, MTP

Chain

signal peptide:1-18, chain:19-894

Reference Genes

BioGPS Gene:4547 MTTP

COSMIC (genes):MTTP MTTP

CTD Gene:4547 MTTP

dbSNP Gene:4547 MTTP

ENSEMBL:ENSG00000138823.14 MTTP

HGNC:7467 MTTP

KEGG Gene (Homo sapiens):4547 MTTP

Monarch:4547 MTTP

NCBI Gene:4547 MTTP

OMIM:157147 MTTP

UCSC:P55157 MTTP

Reference Transcript

Other Identifiers

0002510022

11729799_at

11729800_a_at

11749111_a_at

11761391_at

16969197

205675_PM_at

205675_at

2737245

2737246

2737248

2737250

2737258

2737259

2737262

2737263

2737265

2737266

2737267

2737268

2737269

2737270

2737271

2737272

2737273

2737274

2737275

2737276

2737277

2737279

2737282

2737284

2737286

2737287

2737288

2737289

38891_at

4547

8096580

84656_at

A_14_P131251

A_14_P200128

A_23_P213171

A_33_P3215457

GE62503

GE726749

GO:0005215

GO:0005319

GO:0005515

GO:0005548

GO:0005622

GO:0005737

GO:0005783

GO:0005788

GO:0005791

GO:0005794

GO:0005829

GO:0005886

GO:0006497

GO:0006629

GO:0006641

GO:0006869

GO:0007623

GO:0008289

GO:0009306

GO:0015914

GO:0015918

GO:0016323

GO:0031526

GO:0031528

GO:0031982

GO:0032991

GO:0034185

GO:0034197

GO:0034374

GO:0034377

GO:0034378

GO:0034379

GO:0036211

GO:0042157

GO:0042632

GO:0042953

GO:0043226

GO:0043235

GO:0044877

GO:0046982

GO:0051592

GO:0051649

GO:0061024

GO:0065003

GO:0120009

GO:0120013

GO:0120014

GO:0120019

GO:0120020

GO:0140344

GO:1902388

GO:1902389

GO:1904121

HMNXSV003006589

HMNXSV003050010

Hs.195799.0.S2_3p_at

ILMN_1774742

PH_hs_0011571

TC04000516.hg

X91148_at

Participates

as a component of

MTTP:PDI:lipid complex [endoplasmic reticulum lumen] (Homo sapiens)

Inferred To

mttp.1 [endoplasmic reticulum lumen] (Xenopus tropicalis)

mttp [endoplasmic reticulum lumen] (Danio rerio)

MTTP [endoplasmic reticulum lumen] (Bos taurus)

MTTP [endoplasmic reticulum lumen] (Canis familiaris)

MTTP [endoplasmic reticulum lumen] (Gallus gallus)

MTTP [endoplasmic reticulum lumen] (Sus scrofa)

dsc-4 [endoplasmic reticulum lumen] (Caenorhabditis elegans)

Mttp [endoplasmic reticulum lumen] (Mus musculus)

Mttp [endoplasmic reticulum lumen] (Rattus norvegicus)

Mtp [endoplasmic reticulum lumen] (Drosophila melanogaster)

Cross References

RefSeq

NP_001287714.1, NP_000244.2

ZINC - World Drugs

MTP_HUMAN

OpenTargets

ENSG00000138823

ZINC - FDA approved

MTP_HUMAN

ZINC - Substances

MTP_HUMAN

ZINC target

P55157

PRO

P55157

ZINC - Investigational

MTP_HUMAN

HPA

ENSG00000138823-MTTP

GeneCards

P55157

Ensembl

ENSG00000138823, ENSP00000265517, ENST00000265517, ENST00000457717, ENSP00000407350, ENSP00000400821, ENST00000422897

Pharos - Targets

P55157

ZINC - Predictions - Purchasable

MTP_HUMAN

Orphanet

16487

HMDB Protein

HMDBP01619

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P04114 APOB	20	APOB(28-2179) [cytosol] (R-HSA-2395786) APOB(28-2179) [early endosome] (R-HSA-2429651) APOB(28-4563) [lysosomal lumen] (R-HSA-8876369) APOB(28-2179) [endosome lumen] (R-HSA-174716) APOB(28-2179) [endosome membrane] (R-HSA-174762) APOB(28-4563) [plasma membrane] (R-HSA-171089) APOB(28-4563) [clathrin-coated endocytic vesicle membrane] (R-HSA-171155) APOB(28-4563) [endosome lumen] (R-HSA-171119) APOB(28-4563) [endosome membrane] (R-HSA-171121) APOB(28-2179) [clathrin-coated endocytic vesicle membrane] (R-HSA-174788) APOB(28-2179) [plasma membrane] (R-HSA-174625) APOB(28-2179) [endoplasmic reticulum lumen] (R-HSA-174620) APOB(28-2179) [extracellular region] (R-HSA-174770) APOB(28-2179) [endoplasmic reticulum membrane] (R-HSA-174637) APOB(28-4563) [smooth endoplasmic reticulum] (R-HSA-8866317) APOB(28-4563) [endocytic vesicle lumen] (R-HSA-2512789) 10xdHF-10xglutamyl semialdehyde (Pro)-6xL-tyrosine residue-3xOxoH-2xmodified L-lysine residue-N'-formyl-L-kynurenine-APOB(28-4563) [endocytic vesicle lumen] (R-HSA-2239461) AcK-APOB(28-4563) [endocytic vesicle lumen] (R-HSA-2239446) AcK-APOB(28-4563) [extracellular region] (R-HSA-2173751) p-APOB(28-4563) [endoplasmic reticulum lumen] (R-HSA-8957068)	0.697	4

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