Formation of alternative pathway C5 convertase

Stable Identifier
R-HSA-174551
Type
Reaction [transition]
Species
Homo sapiens
Compartment
extracellular region, plasma membrane
ReviewStatus
5/5
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Formation of alternative pathway C5 convertase
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The complex of C3b:Factor Bb, stabilized on the cell surface by properdin, catalyzes the cleavage of C3 to yield C3b and C3a. The C3b is recruited to the C3b:Factor B complex through its interaction with properdin (Daha et al. 1976; Medicus et al. 1976; Hourcade 2006), yielding the alternate C5 convertase.

Literature References
PubMed ID Title Journal Year
950465 C3 requirements for formation of alternative pathway C5 convertase

Fearon, DT, Daha, MR, Austen, KF

J Immunol 1976
978134 Alternative pathway of complement: recruitment of precursor properdin by the labile C3/C5 convertase and the potentiation of the pathway

Medicus, RG, Muller-Eberhard, HJ, Gotze, O

J Exp Med 1976
Participants
Input
Output
Participates
as an event of
Catalyst Activity

serine-type endopeptidase activity of Cell surface:C3b:Bb:Properdin [plasma membrane]

Physical Entity
Cell surface:C3b:Bb:Properdin [plasma membrane] (Homo sapiens)
Activity
serine-type endopeptidase activity (GO:0004252)
Orthologous Events
Formation of alternative pathway C5 convertase (Bos taurus)
Formation of alternative pathway C5 convertase (Canis familiaris)
Formation of alternative pathway C5 convertase (Danio rerio)
Formation of alternative pathway C5 convertase (Mus musculus)
Formation of alternative pathway C5 convertase (Sus scrofa)
Formation of alternative pathway C5 convertase (Xenopus tropicalis)
Formation of alternate C5 convertase (Gallus gallus)
Authored
de Bono, B  (2004-08-04)
Reviewed
D'Eustachio, P  (2006-07-04)
Created
de Bono, B  (2006-02-20)
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