Formation of alternative pathway C5 convertase

Stable Identifier
R-HSA-174551
Type
Reaction
Species
Homo sapiens
Compartment
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The complex of C3b:Factor Bb, stabilized on the cell surface by properdin, catalyzes the cleavage of C3 to yield C3b and C3a. The C3b is recruited to the C3b:Factor B complex through its interaction with properdin (Daha et al. 1976; Medicus et al. 1976; Hourcade 2006), yielding the alternate C5 convertase.

Literature References
PubMed ID Title Journal Year
950465 C3 requirements for formation of alternative pathway C5 convertase

Fearon, DT, Daha, MR, Austen, KF

J Immunol 1976
978134 Alternative pathway of complement: recruitment of precursor properdin by the labile C3/C5 convertase and the potentiation of the pathway

Medicus, RG, Muller-Eberhard, HJ, Gotze, O

J Exp Med 1976
Participants
Participates
Catalyst Activity

serine-type endopeptidase activity of Cell surface:C3b:Bb:Properdin [plasma membrane]

Orthologous Events
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