The complex of C3b:Factor Bb, stabilized on the cell surface by properdin, catalyzes the cleavage of C3 to yield C3b and C3a. The C3b is recruited to the C3b:Factor B complex through its interaction with properdin (Daha et al. 1976; Medicus et al. 1976; Hourcade 2006), yielding the alternate C5 convertase.
Fearon, DT, Daha, MR, Austen, KF
Medicus, RG, Muller-Eberhard, HJ, Gotze, O
serine-type endopeptidase activity of Cell surface:C3b:Bb:Properdin [plasma membrane]
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