Joining of adjacent Okazaki fragments of the C-strand

Stable Identifier
R-HSA-174456
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Removal of the flap by FEN-1 leads to the generation of a nick between the 3'-end of the upstream Okazaki fragment and the 5'-end of the downstream Okazaki fragment. DNA ligase I then seals the nicks between adjacent processed Okazaki fragments to generate intact double-stranded DNA at the telomere.

Participants
Participant Of
Event Information
Go Biological Process
Catalyst Activity
Catalyst Activity
Title
DNA ligase activity of LIG1 [nucleoplasm]
Physical Entity
Activity
Orthologous Events
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Reviewed
Created