Reactome | Recruitment of DNA2 endonuclease to the C strand

Recruitment of DNA2 endonuclease to the C strand

Stable Identifier

R-HSA-174451

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

Locations in the PathwayBrowser

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Cell Cycle (Homo sapiens)

- Chromosome Maintenance (Homo sapiens)
  - Telomere Maintenance (Homo sapiens)
    - Extension of Telomeres (Homo sapiens)
      - Telomere C-strand (Lagging Strand) Synthesis (Homo sapiens)
        
        Processive synthesis on the C-strand of the telomere (Homo sapiens)
        
        Removal of the Flap Intermediate from the C-strand (Homo sapiens)
        
        Recruitment of DNA2 endonuclease to the C strand (Homo sapiens)

General

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Recruitment of DNA2 endonuclease to the C strand

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After RPA binds the long flap, it recruits the DNA2 helicase/endonuclease which removes the initiator RNA primers of Okazaki fragments (Bae et al. 2001). DNA2 is also needed to resolve G quadruplexes (G4), DNA structures commonly formed by polyguanine-rich telomeric DNA sequences (Masuda-Sasa et al. 2008, Lin et al. 2013).

Literature References

PubMed ID	Title	Journal	Year
23604072	Mammalian DNA2 helicase/nuclease cleaves G-quadruplex DNA and is required for telomere integrity Campbell, J, Dai, H, Hu, J, Sampathi, S, Shin-Ya, K, Zheng, L, Zhou, M, Huang, Q, Liu, C, Lin, W, Chai, W, Shen, B	EMBO J.	2013
18593712	Processing of G4 DNA by Dna2 helicase/nuclease and replication protein A (RPA) provides insights into the mechanism of Dna2/RPA substrate recognition Peng, XP, Masuda-Sasa, T, Polaczek, P, Chen, L, Campbell, JL	J. Biol. Chem.	2008