After RPA binds the long flap, it recruits the DNA2 helicase/endonuclease which removes the initiator RNA primers of Okazaki fragments (Bae et al. 2001). DNA2 is also needed to resolve G quadruplexes (G4), DNA structures commonly formed by polyguanine-rich telomeric DNA sequences (Masuda-Sasa et al. 2008, Lin et al. 2013).